| Name | Name | ERA |
| Mike Hedlund | Stallions | 0.67 |
| Pat Dobson | Peppers | 0.78 |
| Ken Sanders | Spiders | 1.29 |
| Bill Gogolewski | Cubs | 1.50 |
| Tom Murphy | Dukes | 1.55 |
| George Stone* | Rats | 1.62 |
| Vida Blue* | Thunder | 1.63 |
| Sonny Siebert | Triangles | 1.70 |
| Skip Lockwood | Mountaineers | 1.70 |
| Tom Seaver | Rats | 1.71 |
| Jim McGlothlin | Black Sox | 1.73 |
| Gaylord Perry | Rats | 1.93 |
| Roger Moret* | Black Sox | 2.11 |
| Ray Culp | Rats | 2.28 |
| Fergie Jenkins | Tourists | 2.31 |
| Dick Drago | Mountaineers | 2.31 |
| Wilbur Wood* | Thunder | 2.34 |
| Don Wilson | Thunder | 2.36 |
| Tom Hall* | Rats | 2.36 |
| Bob Gibson | Stars | 2.38 |
| Dick Hall | Peppers | 2.38 |
| Ken Forsch | Tigers | 2.43 |
| Dave Roberts* | Mountaineers | 2.44 |
| Dan McGinn* | Eagles | 2.45 |
| Clay Kirby | Red Streaks | 2.45 |
| Casey Cox | Spiders | 2.45 |
| Catfish Hunter | Thunder | 2.47 |
| Phil Niekro | Saxons | 2.54 |
| Bill Lee* | Eels | 2.61 |
| Sam McDowell* | Tourists | 2.65 |
| Mike Cuellar* | Chiefs | 2.72 |
| Les Cain* | Eels | 2.76 |
| Bill Hands | Tigers | 2.85 |
| Ken Holtzman* | Forest Citys | 2.90 |
| Jack Billingham | Dukes | 2.92 |
| Ray Sadecki* | Red Streaks | 2.92 |
| Diego Segui | Cubs | 2.93 |
| Tom Bradley | Triangles | 2.94 |
| Bill Parsons | Tigers | 2.96 |
| Don Sutton | Chiefs | 2.96 |
| Marty Pattin | Red Streaks | 3.03 |
| Bob Johnson | Black Sox | 3.11 |
| Dock Ellis | Stars | 3.12 |
| Steve Kline | Stallions | 3.12 |
| Gary Peters* | Tourists | 3.15 |
| Stan Bahnsen | Spiders | 3.16 |
| Rudy May* | Chiefs | 3.16 |
| Bill Singer | Stars | 3.20 |
| Denny McLain | Eels | 3.21 |
| Alan Foster | Red Streaks | 3.21 |
| Mickey Lolich* | Spiders | 3.23 |
| Bill Stoneman | Mountaineers | 3.26 |
| Joe Coleman | Forest Citys | 3.31 |
| Jim Kaat* | Cubs | 3.35 |
| Joe Niekro | Eagles | 3.38 |
| Andy Messersmith | Red Storm | 3.49 |
| Tommy John* | Peppers | 3.55 |
| Steve Renko | Eagles | 3.55 |
| Don Gullett* | Dukes | 3.55 |
| Clyde Wright* | Volcanoes | 3.57 |
| Lew Krausse | Cubs | 3.67 |
| Ron Reed | Tourists | 3.68 |
| Al Downing* | Saxons | 3.73 |
| Milt Pappas | Dukes | 3.75 |
| Mel Stottlemyre | Triangles | 3.80 |
| Reggie Cleveland | Stars | 3.83 |
| Bert Blyleven | Mountaineers | 3.86 |
| Gary Nolan | Red Storm | 3.89 |
| Jim McAndrew | Millers | 3.95 |
| Nelson Briles | Volcanoes | 3.99 |
| Fritz Peterson* | Red Storm | 4.05 |
| Wayne Simpson | Millers | 4.05 |
| Nolan Ryan | Eels | 4.20 |
| Wade Blasingame* | Forest Citys | 4.22 |
| Jim Perry | Volcanoes | 4.26 |
| Bob Moose | Tigers | 4.29 |
| Grant Jackson* | Spiders | 4.35 |
| Al Fitzmorris | Millers | 4.41 |
| Rick Wise | Saxons | 4.47 |
| Chris Short* | Spiders | 4.58 |
| Rich Hand | Spiders | 4.58 |
| Joe Moeller | Red Storm | 4.64 |
| Ross Grimsley* | Forest Citys | 4.75 |
| Steve Hargan | Peppers | 4.91 |
| Mike Kilkenny* | Eagles | 4.97 |
| Ron Bryant* | Tigers | 5.14 |
| Steve Arlin | Red Storm | 5.17 |
| Juan Marichal | Black Sox | 5.20 |
| Dave McNally* | Triangles | 5.24 |
| Steve Blass | Saxons | 5.36 |
| Dick Bosman | Stallions | 5.49 |
| Barry Lersch | Black Sox | 5.55 |
| Claude Osteen* | Peppers | 5.57 |
| Jim Bunning | Black Sox | 6.00 |
| Jim Nash | Volcanoes | 6.14 |
| Jim Lonborg | Cubs | 6.38 |
| Ken Reynolds* | Millers | 6.62 |
| Gary Gentry | Tigers | 6.62 |
| Carl Morton | Eagles | 6.81 |
| Tom Phoebus | Millers | 6.92 |
| Jim Palmer | Cubs | 6.94 |
| Paul Splittorff* | Eels | 7.64 |
| Chuck Dobson | Spiders | 7.91 |