| Name | Name | ERA |
| Randy Jones* | Tigers | 2.02 |
| Tom Seaver | Rats | 2.06 |
| Catfish Hunter | Thunder | 2.38 |
| Marty Pattin | Moondogs | 2.50 |
| Bert Blyleven | Mountaineers | 2.51 |
| Ed Halicki | Rats | 2.53 |
| Don Gullett* | Rats | 2.56 |
| Gaylord Perry | Rats | 2.63 |
| Steve Busby | Tigers | 2.73 |
| Burt Hooton | Mountaineers | 2.77 |
| Ron Reed | Tourists | 2.79 |
| Jon Matlack* | G's | 2.81 |
| Vida Blue* | Thunder | 2.83 |
| Pete Broberg | Saxons | 2.84 |
| Jim Palmer | Cubs | 3.00 |
| Jim Barr | Spiders | 3.02 |
| Doug Rau* | Black Sox | 3.02 |
| Dennis Leonard | Volcanoes | 3.04 |
| Bob Forsch | Dukes | 3.06 |
| Don Sutton | Mountaineers | 3.10 |
| Al Fitzmorris | Forest Citys | 3.14 |
| Ray Bare | Black Sox | 3.15 |
| Paul Splittorff* | Phillies | 3.17 |
| Woodie Fryman* | Phillies | 3.17 |
| Joe McIntosh | Volcanoes | 3.19 |
| Bruce Kison | Dodgers | 3.20 |
| Vern Ruhle | Dukes | 3.22 |
| Andy Messersmith | Nationals | 3.22 |
| Steve Rogers | Dukes | 3.24 |
| Ray Burris | Stars | 3.28 |
| J.R. Richard | Thunder | 3.30 |
| John Montefusco | G's | 3.30 |
| John Candelaria* | Peppers | 3.32 |
| Larry Christenson | Cubs | 3.34 |
| Frank Tanana* | Black Sox | 3.34 |
| Ken Holtzman* | Forest Citys | 3.36 |
| Jerry Reuss* | Nationals | 3.38 |
| Steve Stone | Dodgers | 3.38 |
| Fritz Peterson* | Nationals | 3.39 |
| Bill Bonham | Saxons | 3.41 |
| Phil Niekro | Eagles | 3.45 |
| Rudy May* | Eagles | 3.45 |
| Jim Slaton | Stars | 3.47 |
| Steve Hargan | Peppers | 3.50 |
| Glenn Abbott | Black Sox | 3.51 |
| Roger Moret* | Black Sox | 3.55 |
| Jim Bibby | G's | 3.55 |
| Mike Torrez | Hoosiers | 3.56 |
| Stan Bahnsen | Spiders | 3.57 |
| Bill Lee* | Peppers | 3.63 |
| Geoff Zahn* | Spiders | 3.66 |
| Jim Lonborg | Volcanoes | 3.68 |
| Fergie Jenkins | Tourists | 3.70 |
| Mike Cuellar* | Hoosiers | 3.72 |
| Ross Grimsley* | Forest Citys | 3.72 |
| Tom Underwood* | Hoosiers | 3.73 |
| Gary Nolan | Nationals | 3.74 |
| Dick Bosman | G's | 3.75 |
| Roric Harrison | Phillies | 3.75 |
| John Curtis* | Phillies | 3.77 |
| Nolan Ryan | Phillies | 3.79 |
| Jim Kaat* | Cubs | 3.80 |
| Claude Osteen* | Peppers | 3.81 |
| Jim Colborn | Black Sox | 3.81 |
| Dock Ellis | Stars | 3.82 |
| Ed Figueroa | Tigers | 3.82 |
| Jim Rooker* | Cubs | 3.83 |
| Sonny Siebert | Dodgers | 3.85 |
| Rick Wise | Saxons | 3.88 |
| Wilbur Wood* | Thunder | 3.90 |
| Dennis Eckersley | Tigers | 3.91 |
| Jim Hughes | Forest Citys | 3.92 |
| Rick Reuschel | Moondogs | 3.94 |
| Carl Morton | Volcanoes | 3.95 |
| Bill Hands | Mountaineers | 3.98 |
| Dave Goltz | Phillies | 4.00 |
| Ken Brett* | Rats | 4.02 |
| Pat Dobson | Peppers | 4.03 |
| Reggie Cleveland | Tigers | 4.14 |
| John Denny | Saxons | 4.15 |
| Steve Renko | Eagles | 4.16 |
| Fred Norman* | Nationals | 4.18 |
| Fred Scherman* | Triangles | 4.28 |
| Pat Darcy | Triangles | 4.29 |
| Luis Tiant | Forest Citys | 4.30 |
| Pete Falcone* | Volcanoes | 4.35 |
| Joe Coleman | Eagles | 4.36 |
| Jim Umbarger* | Moondogs | 4.38 |
| Vic Albury* | Dodgers | 4.39 |
| Dennis Blair | Tourists | 4.44 |
| Randy Tate | Moondogs | 4.50 |
| Larry Dierker | G's | 4.51 |
| Doug Konieczny | Dodgers | 4.52 |
| Jesse Jefferson | Tourists | 4.55 |
| Dave McNally* | Spiders | 4.55 |
| Mickey Lolich* | Spiders | 4.62 |
| Bill Singer | Stars | 4.63 |
| Lerrin LaGrow | Triangles | 4.65 |
| Tom Dettore | Tourists | 4.67 |
| Doc Medich | Hoosiers | 4.75 |
| Bill Travers* | Moondogs | 4.81 |
| Mike Caldwell* | Saxons | 4.84 |
| Jerry Koosman* | Thunder | 4.87 |
| Dan Spillner | Eagles | 4.90 |
| Dave Roberts* | Cubs | 5.08 |
| Bob Gibson | Stars | 5.18 |
| Clay Kirby | Triangles | 5.30 |
| Lynn McGlothen | Dukes | 5.34 |
| Steve Carlton* | Triangles | 5.35 |
| Jack Billingham | Mountaineers | 5.39 |
| Jim Perry | Triangles | 5.61 |