| Name | Name | ERA |
| Pascual Perez | Scotties | 2.17 |
| Andy McGaffigan | Highlanders | 2.60 |
| Jimmy Key* | Lynx | 2.69 |
| Tom Candiotti | Scotties | 2.72 |
| Mark Gubicza | Bandits | 2.79 |
| Tommy John* | Peppers | 2.85 |
| Greg Mathews* | Wind Surge | 2.95 |
| Rick Reuschel | Scotties | 3.13 |
| Dickie Noles | Bandits | 3.17 |
| Dwight Gooden | Tigers | 3.17 |
| Bret Saberhagen | Hoosiers | 3.32 |
| Rick Mahler | Triangles | 3.34 |
| Bob Welch | Mets | 3.36 |
| Bryn Smith | Volcanoes | 3.38 |
| Dennis Rasmussen* | Mets | 3.40 |
| Dave Schmidt | Brushbacks | 3.45 |
| Charlie Hough | | 3.46 |
| Rich Dotson | Peppers | 3.48 |
| Don Carman* | Scotties | 3.53 |
| Dave Palmer | | 3.61 |
| Jeff Russell | Highlanders | 3.63 |
| Bob Ojeda* | Scotties | 3.74 |
| Sid Fernandez* | Mets | 3.76 |
| Steve Trout* | Brushbacks | 3.78 |
| Bob Knepper* | Mountaineers | 3.78 |
| Kelly Downs | Brushbacks | 3.78 |
| Mark Langston* | Rats | 3.80 |
| Mike Morgan | Wind Surge | 3.81 |
| Bruce Hurst* | Hoosiers | 3.82 |
| Bill Wegman | Peppers | 3.85 |
| Mike Scott | Flames | 3.88 |
| Ed Whitson | Highlanders | 3.94 |
| Roger Clemens | Mets | 3.96 |
| Charles Hudson | Brushbacks | 4.01 |
| Mike Flanagan* | Road | 4.01 |
| Atlee Hammaker* | Spiders | 4.07 |
| Doyle Alexander | Alley Cats | 4.08 |
| Bud Black* | Brushbacks | 4.08 |
| Nolan Ryan | Scotties | 4.08 |
| Dave LaPoint* | Volcanoes | 4.09 |
| Jose Guzman | Tigers | 4.10 |
| Ron Robinson | Brushbacks | 4.11 |
| Al Nipper | Triangles | 4.15 |
| Mark Grant | Spiders | 4.19 |
| Frank Tanana* | Black Sox | 4.23 |
| John Habyan | Highlanders | 4.23 |
| Mark Davis* | Road | 4.23 |
| Joe Magrane* | | 4.26 |
| Mike Dunne | Black Sox | 4.33 |
| Jack Morris | Pelicans | 4.44 |
| Bert Blyleven | Mountaineers | 4.45 |
| Floyd Bannister* | Volcanoes | 4.46 |
| Floyd Youmans | Highlanders | 4.47 |
| Rick Rhoden | Flames | 4.52 |
| Mike Moore | Bandits | 4.52 |
| Bob Forsch | Forest Citys | 4.53 |
| Shane Rawley* | Bandits | 4.55 |
| Ron Guidry* | Hoosiers | 4.55 |
| Charlie Leibrandt* | Hoosiers | 4.55 |
| Ted Higuera* | Rouge | 4.59 |
| Greg Swindell* | Lynx | 4.60 |
| Chuck Finley* | Flames | 4.62 |
| Jose DeLeon | Tigers | 4.67 |
| Bruce Ruffin* | Rouge | 4.67 |
| Scott McGregor* | Highlanders | 4.68 |
| Danny Cox | Forest Citys | 4.72 |
| Phil Niekro | Triangles | 4.74 |
| Scott Sanderson | Mountaineers | 4.75 |
| Ron Darling | Bandits | 4.77 |
| Danny Jackson* | Road | 4.80 |
| Mike Witt | Bandits | 4.83 |
| John Tudor* | Spiders | 4.84 |
| Mike Bielecki | Road | 4.84 |
| Mike Boddicker | Hoosiers | 4.86 |
| Neal Heaton* | Lynx | 4.94 |
| Frank Viola* | Rats | 4.94 |
| Jim Clancy | Pelicans | 4.95 |
| Dave Stewart | Pelicans | 4.96 |
| Bill Gullickson | | 4.98 |
| Zane Smith* | Mountaineers | 5.00 |
| Don Sutton | Mountaineers | 5.00 |
| Tom Browning* | Road | 5.04 |
| Ken Dixon | Black Sox | 5.06 |
| Orel Hershiser | Wind Surge | 5.07 |
| Don Robinson | Spiders | 5.09 |
| Dave Stieb | Rouge | 5.09 |
| Rick Sutcliffe | Forest Citys | 5.10 |
| Joaquin Andujar | Highlanders | 5.13 |
| Bob Sebra | Tigers | 5.14 |
| Bill Long | Volcanoes | 5.20 |
| Storm Davis | Tigers | 5.23 |
| John Candelaria* | Peppers | 5.29 |
| Juan Nieves* | Road | 5.40 |
| Eric Nolte* | Mets | 5.50 |
| Bob Stanley | Spiders | 5.53 |
| Lee Tunnell | Rouge | 5.56 |
| Gene Nelson | Mets | 5.57 |
| Jim Winn | Triangles | 5.60 |
| Chris Bosio | Brushbacks | 5.63 |
| Dennis Martinez | Hoosiers | 5.66 |
| Mike Trujillo | Rats | 5.69 |
| Steve Farr | Spiders | 5.80 |
| Danny Darwin | Lynx | 5.83 |
| Kevin Gross | Wind Surge | 5.90 |
| Mike LaCoss | Brushbacks | 5.93 |
| Jay Tibbs | Highlanders | 6.04 |
| Mike Loynd | Rats | 6.19 |
| Dan Petry | Volcanoes | 6.23 |
| Mike Krukow | Road | 6.24 |
| Brian Fisher | Alley Cats | 6.27 |
| Doug Drabek | Volcanoes | 6.28 |
| Jack Lazorko | Black Sox | 6.29 |
| Rick Honeycutt* | Black Sox | 6.33 |
| Ricky Horton* | Spiders | 6.35 |
| Willie Fraser | Forest Citys | 6.39 |
| Jose Nunez | Rats | 6.40 |
| Steve Ontiveros | Forest Citys | 6.41 |
| Jamie Moyer* | Pelicans | 6.42 |
| Curt Young* | Wind Surge | 6.53 |
| Walt Terrell | Alley Cats | 6.56 |
| Eric Bell* | Forest Citys | 6.61 |
| Bobby Witt | Spiders | 6.68 |
| Mark Eichhorn | Rats | 6.69 |
| Greg Maddux | Triangles | 6.90 |
| Fernando Valenzuela* | Flames | 6.91 |
| Eric Show | Scotties | 6.95 |
| Eric King | Tigers | 6.99 |
| Lee Guetterman* | Lynx | 7.36 |
| Les Lancaster | Flames | 7.38 |
| Scott Bankhead | Peppers | 7.41 |
| Jim Deshaies* | Wind Surge | 7.47 |
| Dan Schatzeder* | Rouge | 7.53 |
| Steve Carlton* | Triangles | 7.73 |
| Andy Hawkins | | 7.82 |
| Ken Schrom | Rouge | 8.28 |
| Len Barker | Pelicans | 8.66 |
| Joe Niekro | Black Sox | 8.90 |