| Name | Name | ERA |
| Teddy Higuera* | Hoosiers | 1.62 |
| Orel Hershiser | Wind Surge | 1.71 |
| Allan Anderson* | Hoosiers | 2.02 |
| Mike Boddicker | Hoosiers | 2.37 |
| Bobby Ojeda* | Scotties | 2.49 |
| Bret Saberhagen | Hoosiers | 2.56 |
| Bob Stanley | Spiders | 2.66 |
| Dave Stieb | Brushbacks | 2.70 |
| Greg Swindell* | Lynx | 2.72 |
| John Dopson | Wind Surge | 2.78 |
| Frank Viola* | Rats | 2.80 |
| Roger Clemens | Mets | 2.80 |
| Pascual Perez | Scotties | 2.82 |
| Bill Wegman | Peppers | 2.87 |
| Joe Magrane* | Mountaineers | 2.87 |
| Don August | Highlanders | 2.89 |
| Jerry Reuss* | Flames | 2.91 |
| Bruce Hurst* | Hoosiers | 2.91 |
| Danny Jackson* | Road | 2.93 |
| Tom Glavine* | Triangles | 2.94 |
| John Tudor* | Spiders | 2.96 |
| Tim Belcher | Black Sox | 2.96 |
| Tom Candiotti | Scotties | 2.98 |
| Tim Leary | Volcanoes | 2.99 |
| Shawn Hillegas | Brushbacks | 2.99 |
| Jack McDowell | Road | 3.00 |
| John Smiley* | Peppers | 3.04 |
| Bryn Smith | Volcanoes | 3.08 |
| Kelly Downs | Brushbacks | 3.11 |
| Mark Gubicza | Bandits | 3.13 |
| Charlie Leibrandt* | Lakers | 3.15 |
| Chris Bosio | Brushbacks | 3.17 |
| Pete Smith | Brushbacks | 3.23 |
| Jose Bautista | Road | 3.24 |
| Curt Young* | Wind Surge | 3.31 |
| Zane Smith* | Mountaineers | 3.35 |
| David Cone | Lynx | 3.49 |
| Greg Maddux | Triangles | 3.51 |
| Charlie Hough | Alley Cats | 3.51 |
| Mike Scott | | 3.52 |
| Fred Toliver | | 3.53 |
| John Farrell | Forest Citys | 3.56 |
| Eric Show | Scotties | 3.60 |
| Dave Stewart | Pelicans | 3.70 |
| Dwight Gooden | Tigers | 3.74 |
| Mike Moore | Bandits | 3.76 |
| Rick Reuschel | Alley Cats | 3.77 |
| Doug Drabek | Volcanoes | 3.79 |
| Dennis Martinez | Hoosiers | 3.79 |
| Larry McWilliams* | Lakers | 3.80 |
| Floyd Bannister* | Volcanoes | 3.81 |
| John Candelaria* | Peppers | 3.82 |
| Bob Welch | Mets | 3.82 |
| Melido Perez | Rats | 3.84 |
| Atlee Hammaker* | Spiders | 3.87 |
| Willie Fraser | Forest Citys | 3.88 |
| Rick Mahler | Triangles | 3.88 |
| Jose DeLeon | Tigers | 3.89 |
| Jim Deshaies* | Wind Surge | 3.90 |
| Rick Sutcliffe | Forest Citys | 3.94 |
| Mike Witt | Bandits | 3.96 |
| Scott Bankhead | Peppers | 3.96 |
| Neil Allen | | 3.97 |
| David Palmer | Road | 4.02 |
| Doyle Alexander | Alley Cats | 4.06 |
| Mike Smithson | Lakers | 4.08 |
| Rich Yett | Flames | 4.08 |
| Mark Langston* | Rats | 4.11 |
| Jeff M. Robinson | | 4.13 |
| Jimmy Key* | Lynx | 4.15 |
| Don Sutton | Mountaineers | 4.15 |
| Paul Kilgus* | Rats | 4.20 |
| Don Robinson | Spiders | 4.20 |
| Jimmy Jones | Peppers | 4.25 |
| Bobby Witt | Spiders | 4.28 |
| Shane Rawley* | Lakers | 4.31 |
| Sid Fernandez* | Mets | 4.33 |
| Jamie Moyer* | Pelicans | 4.35 |
| Mike Campbell | Mountaineers | 4.37 |
| Mark Grant | Spiders | 4.37 |
| Jeff Russell | Highlanders | 4.39 |
| Danny Darwin | Lynx | 4.41 |
| Bob Knepper* | Mountaineers | 4.41 |
| Jose Rijo | Forest Citys | 4.42 |
| Tom Browning* | Road | 4.45 |
| Bruce Ruffin* | Lakers | 4.47 |
| Dennis Rasmussen* | Mets | 4.48 |
| Jose Guzman | Tigers | 4.50 |
| Tommy John* | Lakers | 4.51 |
| Bob Walk | Lynx | 4.63 |
| Dave LaPoint* | Volcanoes | 4.64 |
| Ron Darling | Bandits | 4.73 |
| Bert Blyleven | Mountaineers | 4.74 |
| Jose Alvarez | Flames | 4.74 |
| Dan Petry | Lakers | 4.77 |
| Mark Williamson | Mets | 4.78 |
| Fernando Valenzuela* | Flames | 4.82 |
| Storm Davis | Tigers | 4.85 |
| Ed Whitson | Highlanders | 4.98 |
| Brian Fisher | | 5.01 |
| Lester Lancaster | Flames | 5.03 |
| Nolan Ryan | Scotties | 5.03 |
| Frank Tanana* | Black Sox | 5.13 |
| Mike Birkbeck | Spiders | 5.15 |
| Jack Morris | Pelicans | 5.18 |
| Kevin Gross | Wind Surge | 5.18 |
| Jim Clancy | Pelicans | 5.23 |
| Andy Hawkins | Forest Citys | 5.23 |
| Oil Can Boyd | Mets | 5.24 |
| Walt Terrell | Alley Cats | 5.38 |
| Billy Swift | Flames | 5.38 |
| Bob Forsch | Forest Citys | 5.40 |
| Charlie Lea | Highlanders | 5.64 |
| Jeff Pico | Black Sox | 5.69 |
| Neal Heaton* | Lynx | 5.71 |
| Jay Tibbs | Highlanders | 5.75 |
| Kirk McCaskill | Black Sox | 5.83 |
| Mike Maddux | Black Sox | 6.44 |
| Mike Dunne | Black Sox | 6.86 |