| Name | Name | ERA |
| Israel Sanchez* | Rats | 0.72 |
| Duane Ward | Triangles | 0.93 |
| Teddy Higuera* | Hoosiers | 0.95 |
| Mark Gubicza | Bandits | 0.96 |
| Bob Stanley | Spiders | 1.23 |
| Kent Tekulve | Rats | 1.45 |
| Keith Atherton | Black Sox | 1.54 |
| Pascual Perez | Scotties | 1.55 |
| Mike Witt | Bandits | 1.64 |
| Randy Myers* | Volcanoes | 1.74 |
| Roger Clemens | Mets | 1.77 |
| Greg Cadaret* | Highlanders | 1.93 |
| Floyd Bannister* | Volcanoes | 1.94 |
| Jose DeLeon | Tigers | 1.97 |
| Pete Smith | Brushbacks | 1.98 |
| Greg Swindell* | Lynx | 1.99 |
| Bob Welch | Mets | 2.00 |
| Don Carman* | Scotties | 2.03 |
| Larry Andersen | Pelicans | 2.08 |
| Brian Holton | Highlanders | 2.11 |
| Tim Leary | Volcanoes | 2.17 |
| Eric King | Tigers | 2.18 |
| Odell Jones | Bandits | 2.25 |
| Allan Anderson* | Hoosiers | 2.28 |
| John Franco* | Pelicans | 2.29 |
| Greg Maddux | Triangles | 2.33 |
| Todd Worrell | Mets | 2.33 |
| Melido Perez | Rats | 2.35 |
| John Tudor* | Spiders | 2.37 |
| Tom Henke | Pelicans | 2.45 |
| Tim Belcher | Black Sox | 2.45 |
| Cris Carpenter | Peppers | 2.53 |
| Jeff M. Robinson | Bandits | 2.58 |
| Orel Hershiser | Wind Surge | 2.59 |
| Mike Scott | Flames | 2.60 |
| Charlie Hough | Alley Cats | 2.61 |
| Juan Nieves* | Road | 2.61 |
| Charlie Leibrandt* | Lakers | 2.63 |
| Eric Plunk | Triangles | 2.66 |
| Jimmy Key* | Lynx | 2.68 |
| Mike Boddicker | Hoosiers | 2.70 |
| Tom Glavine* | Triangles | 2.70 |
| Tom Candiotti | Scotties | 2.72 |
| John Candelaria* | Peppers | 2.75 |
| Dave Stieb | Brushbacks | 2.76 |
| Zane Smith* | Mountaineers | 2.83 |
| Norm Charlton* | Lynx | 2.84 |
| Jose Alvarez | Flames | 2.86 |
| Bruce Hurst* | Hoosiers | 2.86 |
| Don Robinson | Spiders | 2.91 |
| Jack McDowell | Road | 2.93 |
| Steve Bedrosian | Highlanders | 2.95 |
| Frank Viola* | Rats | 2.98 |
| John Smiley* | Peppers | 2.98 |
| Jerry Reuss* | Flames | 3.00 |
| Bret Saberhagen | Hoosiers | 3.03 |
| Tom Browning* | Road | 3.06 |
| Rick Mahler | Triangles | 3.09 |
| Joe Magrane* | Mountaineers | 3.10 |
| Sid Fernandez* | Mets | 3.10 |
| John Dopson | Wind Surge | 3.14 |
| Dwight Gooden | Tigers | 3.19 |
| Mike Smithson | Lakers | 3.20 |
| Doyle Alexander | Alley Cats | 3.21 |
| Bob Knepper* | Mountaineers | 3.24 |
| Dennis Martinez | Hoosiers | 3.25 |
| Doug Drabek | Volcanoes | 3.28 |
| Rick Sutcliffe | Forest Citys | 3.29 |
| Willie Fraser | Forest Citys | 3.35 |
| Greg Minton | Highlanders | 3.38 |
| Ron Darling | Bandits | 3.40 |
| Bobby Ojeda* | Scotties | 3.42 |
| Todd Burns | Rats | 3.43 |
| Scott Bankhead | Peppers | 3.45 |
| Eric Show | Scotties | 3.47 |
| Mark Langston* | Rats | 3.47 |
| Erik Hanson | Forest Citys | 3.48 |
| Bob Walk | Lynx | 3.57 |
| Fred Toliver | Lakers | 3.60 |
| Jamie Moyer* | Pelicans | 3.64 |
| Atlee Hammaker* | Spiders | 3.67 |
| Dennis Rasmussen* | Mets | 3.68 |
| Chris Bosio | Brushbacks | 3.68 |
| John Farrell | Forest Citys | 3.68 |
| Tommy John* | Lakers | 3.69 |
| David Cone | Lynx | 3.70 |
| Kelly Downs | Brushbacks | 3.72 |
| Jeff Parrett | Wind Surge | 3.74 |
| Bobby Witt | Spiders | 3.76 |
| Danny Darwin | Lynx | 3.76 |
| Bryn Smith | Volcanoes | 3.79 |
| Mike Campbell | Mountaineers | 3.82 |
| Mike Moore | Bandits | 3.86 |
| Dan Petry | Lakers | 3.86 |
| Jose Guzman | Tigers | 3.91 |
| Danny Jackson* | Road | 3.92 |
| Rich Dotson | Peppers | 3.93 |
| David Palmer | Road | 3.95 |
| Mike Harkey | Bandits | 3.98 |
| Scott Bailes* | Triangles | 4.00 |
| Don August | Highlanders | 4.00 |
| Bruce Ruffin* | Lakers | 4.00 |
| Mario Soto | Rats | 4.06 |
| Jeff Russell | Highlanders | 4.25 |
| Doug Sisk | Rats | 4.30 |
| Danny Cox | Mets | 4.34 |
| Walt Terrell | Alley Cats | 4.37 |
| Craig McMurtry | Pelicans | 4.45 |
| Kevin Gross | Wind Surge | 4.65 |
| Shane Rawley* | Lakers | 4.74 |
| Ed Whitson | Highlanders | 4.75 |
| Billy Swift | Flames | 4.78 |
| Jeff Pico | Black Sox | 4.85 |
| Bert Blyleven | Mountaineers | 4.88 |
| Mike Maddux | Black Sox | 4.91 |
| Bill Wegman | Peppers | 5.00 |
| Oil Can Boyd | Mets | 5.06 |
| Paul Kilgus* | Rats | 5.06 |
| Tim Birtsas* | Tigers | 5.09 |
| Charlie Lea | Highlanders | 5.09 |
| Steve Shields | Flames | 5.12 |
| Dave Stewart | Pelicans | 5.16 |
| Jim Clancy | Pelicans | 5.17 |
| Jose Bautista | Road | 5.23 |
| Rick Rhoden | Flames | 5.23 |
| Al Leiter* | Pelicans | 5.30 |
| Mark Williamson | Mets | 5.40 |
| Mike LaCoss | Brushbacks | 5.48 |
| Dave LaPoint* | Volcanoes | 5.58 |
| Jim Deshaies* | Wind Surge | 5.66 |
| Les Straker | Wind Surge | 5.67 |
| Mike Birkbeck | Spiders | 5.70 |
| Frank Tanana* | Black Sox | 5.70 |
| Kirk McCaskill | Black Sox | 5.77 |
| Randy O'Neal | Alley Cats | 5.79 |
| Storm Davis | Tigers | 5.85 |
| Rick Reuschel | Alley Cats | 5.87 |
| Mark Grant | Spiders | 5.94 |
| Larry McWilliams* | Lakers | 5.96 |
| Paul Gibson* | Lakers | 6.00 |
| Lester Lancaster | Flames | 6.06 |
| Neil Allen | Mountaineers | 6.08 |
| Andy Hawkins | Forest Citys | 6.28 |
| Brian Holman | Forest Citys | 6.29 |
| Jose Rijo | Forest Citys | 6.35 |
| Jack Morris | Pelicans | 6.50 |
| Chuck Finley* | Flames | 6.60 |
| Mike Flanagan* | Road | 6.62 |
| Jay Tibbs | Highlanders | 6.75 |
| Brian Fisher | Alley Cats | 6.91 |
| Mike Dunne | Black Sox | 7.02 |
| Nolan Ryan | Scotties | 7.07 |
| Jimmy Jones | Peppers | 7.30 |
| Bob Forsch | Forest Citys | 7.85 |
| Jeff Bittiger | Black Sox | 8.27 |
| Jeff Robinson | Pelicans | 9.19 |