| Name | Name | ERA |
| Jose Alvarez | Owls | 0.43 |
| Jeff Russell | Highlanders | 0.44 |
| Dennis Lamp | Mets | 1.23 |
| Todd Burns | Rats | 1.46 |
| Charlie Puleo | Highlanders | 1.47 |
| Juan Berenguer | Lakers | 1.57 |
| Danny Darwin | Lynx | 1.82 |
| Greg W. Harris | Hoosiers | 1.88 |
| Don Robinson | Barons | 2.01 |
| Mike Scott | Triangles | 2.14 |
| Ken Howell | Pelicans | 2.14 |
| Jeff Peterek | Rats | 2.21 |
| Bill Landrum | Forest Citys | 2.21 |
| Gene Nelson | Mets | 2.25 |
| Randy Kramer | Road | 2.25 |
| Craig Lefferts* | Lakers | 2.25 |
| Nolan Ryan | Scotties | 2.28 |
| Dave Smith | Black Sox | 2.29 |
| John Smiley* | Peppers | 2.29 |
| Orel Hershiser | Wind Surge | 2.30 |
| Mark Knudson | Hoosiers | 2.33 |
| Dave Stewart | Pelicans | 2.34 |
| Charlie Leibrandt* | Lakers | 2.36 |
| Mark Gubicza | Rainiers | 2.38 |
| Mark Thurmond* | Road | 2.38 |
| Bret Saberhagen | Hoosiers | 2.44 |
| Pete Smith | Brushbacks | 2.44 |
| Shawn Hillegas | Road | 2.45 |
| Ed Whitson | Hoosiers | 2.49 |
| Jim Deshaies* | Wind Surge | 2.55 |
| Scott Sanderson | Mountaineers | 2.56 |
| Bryan Clutterbuck | Rainiers | 2.57 |
| Roy Smith | Mountaineers | 2.60 |
| Eric King | Tigers | 2.61 |
| Ramon Martinez | Triangles | 2.63 |
| Greg Maddux | Triangles | 2.64 |
| Jerry Reed | Pelicans | 2.75 |
| Bobby Ojeda* | Scotties | 2.75 |
| Pascual Perez | Scotties | 2.76 |
| Bob Welch | Mets | 2.81 |
| Atlee Hammaker* | Barons | 2.82 |
| Jimmy Key* | Lynx | 2.82 |
| Les Lancaster | Triangles | 2.84 |
| Ron Robinson | Brushbacks | 2.86 |
| Mike Smithson | Lakers | 2.87 |
| Tom Candiotti | Lakers | 2.87 |
| Scott Bailes* | Owls | 2.93 |
| Chuck Finley* | Owls | 2.96 |
| Brian DuBois* | Rats | 2.97 |
| Kirk McCaskill | Black Sox | 2.98 |
| Greg Harris | Hoosiers | 3.04 |
| David Wells* | Brushbacks | 3.10 |
| Rich Yett | Owls | 3.10 |
| Mike LaCoss | Brushbacks | 3.20 |
| Mike Witt | Rainiers | 3.20 |
| John Dopson | Wind Surge | 3.20 |
| Rob Murphy* | Wind Surge | 3.26 |
| Mike Bielecki | Alley Cats | 3.28 |
| Danny Jackson* | Road | 3.30 |
| Fernando Valenzuela* | Owls | 3.35 |
| Bryn Smith | Volcanoes | 3.38 |
| Kevin Brown | Highlanders | 3.40 |
| Bert Blyleven | Mountaineers | 3.40 |
| Dale Mohorcic | Pelicans | 3.43 |
| Andy McGaffigan | Highlanders | 3.44 |
| Keith Atherton | Black Sox | 3.44 |
| Rick Reuschel | Alley Cats | 3.46 |
| Clay Parker | Scotties | 3.48 |
| Rod Nichols | Black Sox | 3.48 |
| Larry McWilliams* | Lakers | 3.50 |
| Charlie Hough | Alley Cats | 3.52 |
| Jeff Ballard* | Peppers | 3.53 |
| Tom Gordon | Highlanders | 3.54 |
| John Farrell | Forest Citys | 3.56 |
| Roger Clemens | Mets | 3.58 |
| Rick Sutcliffe | Forest Citys | 3.59 |
| Sid Fernandez* | Mets | 3.60 |
| Frank Viola* | Rats | 3.65 |
| Mark Grant | Barons | 3.67 |
| Melido Perez | Rats | 3.71 |
| Joe Magrane* | Mountaineers | 3.74 |
| John Costello | Road | 3.74 |
| Dennis Martinez | Hoosiers | 3.75 |
| Derek Lilliquist* | Highlanders | 3.79 |
| David Cone | Lynx | 3.80 |
| Bruce Hurst* | Hoosiers | 3.82 |
| Mike Morgan | Wind Surge | 3.86 |
| Rick Mahler | Road | 3.92 |
| Chuck Crim | Mountaineers | 3.93 |
| Dwight Gooden | Tigers | 3.96 |
| Curt Young* | Tigers | 3.99 |
| Jim Acker | Volcanoes | 4.01 |
| Scott Garrelts | Volcanoes | 4.06 |
| John Smoltz | Barons | 4.07 |
| Tim Leary | Volcanoes | 4.08 |
| Bud Black* | Scotties | 4.12 |
| Joe Price* | Barons | 4.15 |
| Marty Clary | Forest Citys | 4.22 |
| Chris Bosio | Brushbacks | 4.24 |
| Jamie Moyer* | Pelicans | 4.26 |
| Jose DeLeon | Tigers | 4.31 |
| Mike Moore | Rainiers | 4.35 |
| Jim Abbott* | Rainiers | 4.36 |
| Bobby Witt | Barons | 4.37 |
| Tom Glavine* | Triangles | 4.46 |
| John Cerutti* | Peppers | 4.50 |
| Rich Gossage | Mountaineers | 4.50 |
| Billy Swift | Owls | 4.53 |
| Dennis Rasmussen* | Mets | 4.54 |
| Tim Belcher | Black Sox | 4.60 |
| John Wetteland | Tigers | 4.60 |
| Ron Darling | Rainiers | 4.60 |
| Jeff Pico | Black Sox | 4.64 |
| Norm Charlton* | Lynx | 4.66 |
| Scott Bankhead | Peppers | 4.73 |
| Mike Flanagan* | Road | 4.81 |
| Brian Holton | Highlanders | 4.88 |
| Bob Milacki | Wind Surge | 4.89 |
| Kevin Gross | Wind Surge | 4.94 |
| Don August | Highlanders | 4.95 |
| Mark Langston* | Rats | 5.01 |
| Dave Stieb | Brushbacks | 5.03 |
| Mike Boddicker | Hoosiers | 5.04 |
| Lee Guetterman* | Lynx | 5.12 |
| Neal Heaton* | Lynx | 5.16 |
| Gary Mielke | Rainiers | 5.19 |
| Doug Drabek | Volcanoes | 5.28 |
| Doyle Alexander | Alley Cats | 5.40 |
| Greg Swindell* | Lynx | 5.40 |
| Ken Hill | Peppers | 5.45 |
| Luis Aquino | Barons | 5.45 |
| Mike Dyer | Volcanoes | 5.53 |
| Teddy Higuera* | Hoosiers | 5.58 |
| Shane Rawley* | Lakers | 5.66 |
| Jim Clancy | Pelicans | 5.70 |
| Greg Hibbard* | Mets | 5.77 |
| Juan Agosto* | Rainiers | 5.85 |
| Andy Hawkins | Forest Citys | 5.95 |
| Frank Wills | Forest Citys | 5.96 |
| Jack Morris | Pelicans | 6.00 |
| Mike Dunne | Black Sox | 6.07 |
| Jerry Reuss* | Owls | 6.07 |
| Walt Terrell | Alley Cats | 6.08 |
| Tom Browning* | Road | 6.10 |
| Paul Gibson* | Lakers | 6.14 |
| Bob Stanley | Rainiers | 6.20 |
| Randy Johnson* | Road | 6.21 |
| Frank Tanana* | Black Sox | 6.21 |
| Storm Davis | Tigers | 6.39 |
| Brian Holman | Forest Citys | 6.64 |
| Bob Walk | Lynx | 6.92 |
| Greg Cadaret* | Highlanders | 6.94 |
| Paul Kilgus* | Rats | 7.14 |
| Bob Knepper* | Mountaineers | 7.14 |
| Dennis Cook* | Mountaineers | 7.20 |
| Dave Johnson | Lakers | 7.36 |
| Jeff M. Robinson | Alley Cats | 7.50 |
| Bruce Ruffin* | Lakers | 7.77 |
| Rich Dotson | Black Sox | 7.80 |
| Terry Mulholland* | Barons | 8.24 |
| Clint Zavaras | Owls | 8.31 |
| Frank Williams | Tigers | 8.72 |
| Steve Rosenberg* | Alley Cats | 9.00 |
| Scott Terry | Triangles | 10.71 |