STAT-ERA-SEP -- All players in database
Regular season
| Primary |
| Name | Name | ERA |
| Walter Johnson | Blue Flames | 1.47 |
| Buster Brown | Cyclones | 1.88 |
| Christy Mathewson | Patriots | 2.02 |
| Ed Walsh | Perfectos | 2.08 |
| Jim Baskette | Rail | 2.26 |
| Buck O'Brien | Maumees | 2.30 |
| Jeff Tesreau | Moondogs | 2.33 |
| Joe Wood | Bombers | 2.45 |
| Larry Cheney | Perfectos | 2.49 |
| Hugh Bedient | Sharks | 2.51 |
| Ad Brennan* | Barnstormers | 2.57 |
| Slim Sallee* | Wildcats | 2.57 |
| George McConnell | Mutuals | 2.57 |
| Claude Hendrix | Rail | 2.68 |
| Willie Mitchell* | Sharks | 2.69 |
| Chief Bender | Maumees | 2.71 |
| Russ Ford | Perfectos | 2.72 |
| Cy Morgan | Mutuals | 2.72 |
| Earl Hamilton* | Wildcats | 2.73 |
| Babe Adams | Sharks | 2.80 |
| George Suggs | Mutuals | 2.84 |
| Doc Crandall | Marauders | 2.84 |
| Jack Warhop | Barnstormers | 2.85 |
| Eppa Rixey* | Sharks | 2.89 |
| Jack Coombs | Bombers | 2.89 |
| Hub Perdue | Mutuals | 2.90 |
| Lefty Tyler* | Marauders | 2.90 |
| Doc White* | Wildcats | 3.00 |
| Otto Hess* | Rail | 3.01 |
| Cliff Curtis | Patriots | 3.07 |
| Jimmy Lavender | Bombers | 3.13 |
| Bert Humphries | Wildcats | 3.14 |
| Ed Willett | Barnstormers | 3.17 |
| Rube Marquard* | Bombers | 3.22 |
| Hooks Wiltse* | Wildcats | 3.26 |
| Ed Reulbach | Pisces | 3.26 |
| Bob Groom | Moondogs | 3.27 |
| Nap Rucker* | Pisces | 3.29 |
| Marty O'Toole | Maumees | 3.30 |
| Jean Dubuc | Marauders | 3.30 |
| Bob Harmon | Marauders | 3.32 |
| Jack Powell | Rail | 3.35 |
| Pete Alexander | Cyclones | 3.37 |
| Fred Blanding | Barnstormers | 3.39 |
| Dixie Walker | Mutuals | 3.47 |
| Mack Allison | Pisces | 3.50 |
| Charley Hall | Blue Flames | 3.54 |
| Earl Moore | Blue Flames | 3.57 |
| Walt Dickson | Cyclones | 3.59 |
| Joe Benz | Maumees | 3.60 |
| Red Ames | Marauders | 3.60 |
| Byron Houck | Moondogs | 3.69 |
| Elmer Knetzer | Blue Flames | 3.70 |
| Joe Engel* | Patriots | 3.71 |
| George Mullin | Blue Flames | 3.71 |
| Ray Collins* | Pisces | 3.73 |
| George Baumgardner | Perfectos | 3.81 |
| Bill Steele | Sharks | 3.83 |
| Earl Yingling* | Rail | 3.90 |
| Vean Gregg* | Patriots | 3.91 |
| Art Fromme | Wildcats | 3.95 |
| Elmer Brown | Barnstormers | 4.07 |
| Howie Camnitz | Cyclones | 4.43 |
| Eddie Plank* | Cyclones | 4.44 |
| Joe Willis* | Patriots | 4.45 |
| Ralph Works | Sharks | 4.47 |
| George Davis | Blue Flames | 4.54 |
| George Kahler | Pisces | 4.58 |
| Rube Benton* | Cyclones | 4.61 |
| Lew Richie | Maumees | 4.63 |
| Rube Geyer | Patriots | 4.75 |
| Hippo Vaughn* | Moondogs | 4.87 |
| Tom Hughes | Perfectos | 4.99 |
| Eddie Stack | Moondogs | 5.19 |