| Name | Name | ERA |
| Jose Santiago | Voyageurs | 1.31 |
| Luis Tiant | Gladiators | 1.46 |
| Bob Gibson | Voyageurs | 1.58 |
| Dean Chance | Voyageurs | 1.62 |
| Juan Marichal | Voyageurs | 1.97 |
| Jim Perry | Angels | 2.06 |
| Gary Nolan | Beavers | 2.06 |
| Mike Kekich* | Elephants | 2.23 |
| Tommy John* | Seals | 2.33 |
| Stan Bahnsen | Lions | 2.34 |
| Bill Hands | Hot Rods | 2.36 |
| Blue Moon Odom | Lions | 2.39 |
| Earl Wilson | Seals | 2.42 |
| Phil Niekro | Totems | 2.45 |
| Denny McLain | Mets | 2.47 |
| Jerry Koosman* | Totems | 2.56 |
| Bob Moose | Mets | 2.58 |
| Sam McDowell* | Seals | 2.62 |
| Jerry Arrigo* | Bishops | 2.64 |
| Claude Osteen* | Rivers | 2.66 |
| Fergie Jenkins | Wild Weasels | 2.68 |
| Pat Jarvis | Gladiators | 2.68 |
| Sonny Siebert | Colts | 2.69 |
| Ray Culp | Rivers | 2.73 |
| Joe Sparma | Angels | 2.73 |
| Gaylord Perry | Mets | 2.73 |
| Dave McNally* | Fortress | 2.76 |
| Mel Stottlemyre | Wild Weasels | 2.91 |
| Tony Cloninger | Fortress | 2.91 |
| Tom Seaver | Gladiators | 2.91 |
| Larry Dierker | Colts | 2.98 |
| Mike McCormick* | Elephants | 2.99 |
| Ray Sadecki* | Gladiators | 3.01 |
| Ron Reed | Marauders | 3.06 |
| Fritz Peterson* | Beavers | 3.06 |
| Steve Carlton* | Hot Rods | 3.06 |
| Mickey Lolich* | Totems | 3.10 |
| Camilo Pascual | Angels | 3.11 |
| Mike Cuellar* | Mets | 3.11 |
| Jim Nash | Hot Rods | 3.11 |
| Don Sutton | Monarchs | 3.13 |
| Steve Blass | Angels | 3.16 |
| Don Cardwell | Wild Weasels | 3.17 |
| Joe Coleman | Lions | 3.17 |
| George Brunet* | Rivers | 3.19 |
| Jim Kaat* | Resolutes | 3.20 |
| Jim Hardin | Resolutes | 3.23 |
| Nelson Briles | Resolutes | 3.26 |
| Joe Horlen | Lions | 3.26 |
| Jim Maloney | Mets | 3.27 |
| Joe Niekro | Elephants | 3.28 |
| Lew Krausse | Bishops | 3.30 |
| Tom Phoebus | Colts | 3.31 |
| Don Drysdale | Monarchs | 3.36 |
| Don Wilson | Colts | 3.38 |
| Larry Jackson | Monarchs | 3.44 |
| Woodie Fryman* | Angels | 3.47 |
| Dave Leonhard | Rivers | 3.47 |
| Ray Washburn | Monarchs | 3.47 |
| Jim Merritt* | Monarchs | 3.47 |
| Dave Giusti | Lions | 3.50 |
| Rich Nye* | Elephants | 3.52 |
| Catfish Hunter | Hot Rods | 3.52 |
| Milt Pappas | Seals | 3.53 |
| Bob Veale* | Bishops | 3.55 |
| Steve Hargan | Resolutes | 3.57 |
| Ken Holtzman* | Marauders | 3.59 |
| Chuck Dobson | Marauders | 3.64 |
| Larry Jaster* | Beavers | 3.64 |
| Jim McGlothlin | Elephants | 3.74 |
| Jack Fisher | Fortress | 3.74 |
| Rick Wise | Bishops | 3.75 |
| Al McBean | Bishops | 3.83 |
| Cisco Carlos | Angels | 3.86 |
| Gary Bell | Rivers | 3.86 |
| Gary Peters* | Beavers | 3.87 |
| Dick Selma | Resolutes | 3.91 |
| Denny Lemaster* | Wild Weasels | 3.99 |
| Sammy Ellis | Totems | 4.24 |
| Jim Bunning | Resolutes | 4.30 |
| Frank Bertaina* | Beavers | 4.60 |
| Bill Singer | Hot Rods | 4.69 |
| Jim Hannan | Fortress | 5.20 |
| Bob Priddy | Marauders | 5.33 |
| Ken Johnson | Fortress | 5.61 |