| Name | Name | ERA |
| Jerry Koosman* | Totems | 1.91 |
| Sam McDowell* | Seals | 1.92 |
| Dave Boswell | Voyageurs | 2.32 |
| Mel Stottlemyre | Wild Weasels | 2.44 |
| Larry Dierker | Colts | 2.47 |
| Phil Niekro | Totems | 2.49 |
| Juan Marichal | Voyageurs | 2.55 |
| Fritz Peterson* | Beavers | 2.57 |
| Dock Ellis | Hot Rods | 2.62 |
| Mickey Lolich* | Totems | 2.65 |
| Jim Perry | Angels | 2.73 |
| Fergie Jenkins | Wild Weasels | 2.73 |
| Bill Hands | Totems | 2.74 |
| Andy Messersmith | Fortress | 2.78 |
| Blue Moon Odom | Hot Rods | 2.80 |
| Bob Gibson | Voyageurs | 2.81 |
| Dave McNally* | Fortress | 2.81 |
| Mike Cuellar* | Mets | 2.85 |
| Tom Seaver | Gladiators | 2.88 |
| Steve Carlton* | Hot Rods | 2.93 |
| Dick Drago | Bay Sox | 2.96 |
| Ray Culp | Rivers | 3.05 |
| Jim Rooker* | Royals | 3.08 |
| Dick Bosman | Wild Weasels | 3.08 |
| Tom Griffin | Elephants | 3.09 |
| Tommy John* | Seals | 3.09 |
| Ray Washburn | Monarchs | 3.12 |
| Jim Palmer | Hot Rods | 3.14 |
| Jim Maloney | Mets | 3.16 |
| Dick Kelley* | Barons | 3.16 |
| Vicente Romo | Rivers | 3.20 |
| Woodie Fryman* | Angels | 3.23 |
| Joe Horlen | Lions | 3.26 |
| Mike Paul* | Seals | 3.27 |
| Dick Selma | Pilots | 3.27 |
| Gary Gentry | Beavers | 3.30 |
| Barry Moore* | Bishops | 3.32 |
| Mike Nagy | Bishops | 3.35 |
| Ken Holtzman* | Marauders | 3.36 |
| Don Wilson | Colts | 3.38 |
| Rick Wise | Bishops | 3.46 |
| Milt Pappas | Seals | 3.49 |
| Don Sutton | Monarchs | 3.53 |
| Jim McAndrew | Beavers | 3.56 |
| Gary Peters* | Beavers | 3.58 |
| Gaylord Perry | Mets | 3.60 |
| Catfish Hunter | Hot Rods | 3.62 |
| Denny McLain | Mets | 3.67 |
| Jerry Johnson | Fortress | 3.68 |
| Roger Nelson | Pilots | 3.70 |
| Casey Cox | Rivers | 3.71 |
| Denny Lemaster* | Wild Weasels | 3.75 |
| Luke Walker* | Elephants | 3.77 |
| Bob Veale* | Bishops | 3.82 |
| Wally Bunker | Voyageurs | 3.84 |
| Claude Osteen* | Rivers | 3.86 |
| Steve Hargan | Yinzers | 3.95 |
| Bill Singer | Rivers | 4.01 |
| Clay Kirby | Barons | 4.01 |
| Bill Stoneman | Barons | 4.03 |
| Mike McCormick* | Beavers | 4.04 |
| Jerry Robertson | Barons | 4.06 |
| Bob Miller | Colts | 4.09 |
| Dick Ellsworth* | Elephants | 4.12 |
| Tom Phoebus | Colts | 4.12 |
| Earl Wilson | Seals | 4.15 |
| Ron Reed | Yinzers | 4.16 |
| Gene Brabender | Bay Sox | 4.16 |
| Jerry Nyman* | Angels | 4.17 |
| Jim Lonborg | Yinzers | 4.18 |
| Rudy May* | Gladiators | 4.19 |
| Jim Hannan | Fortress | 4.21 |
| Jim Ray | Bishops | 4.21 |
| Jim Hardin | Yinzers | 4.22 |
| Al Downing* | Elephants | 4.24 |
| Tom Hall* | Colts | 4.24 |
| Bill Butler* | Barons | 4.25 |
| Jim Kaat* | Marauders | 4.26 |
| Luis Tiant | Gladiators | 4.28 |
| Joe Sparma | Angels | 4.34 |
| Al Santorini | Pilots | 4.36 |
| Tom Murphy | Marauders | 4.45 |
| Lew Krausse | Bishops | 4.45 |
| Grant Jackson* | Voyageurs | 4.47 |
| Fred Talbot | Bay Sox | 4.50 |
| Pat Jarvis | Monarchs | 4.51 |
| Jim Merritt* | Monarchs | 4.53 |
| Mike Wegener | Bay Sox | 4.53 |
| Bobby Bolin | Barons | 4.58 |
| Joe Niekro | Royals | 4.60 |
| Steve Barber* | Bay Sox | 4.79 |
| Jim Nash | Fortress | 4.86 |
| Nelson Briles | Elephants | 4.87 |
| Dick Woodson | Gladiators | 4.90 |
| Tommie Sisk | Royals | 4.95 |
| Steve Blass | Rivers | 4.99 |
| Sonny Siebert | Colts | 4.99 |
| Jim McGlothlin | Lions | 5.08 |
| Chuck Dobson | Pilots | 5.11 |
| Marty Pattin | Pilots | 5.17 |
| Tony Cloninger | Marauders | 5.23 |
| Joe Coleman | Lions | 5.25 |
| Mike Marshall | Bay Sox | 5.50 |
| Stan Bahnsen | Lions | 5.51 |
| Jim Bunning | Yinzers | 5.53 |
| Ray Sadecki* | Gladiators | 5.61 |
| Bill Burbach | Marauders | 5.66 |
| Camilo Pascual | Angels | 6.01 |
| George Brunet* | Royals | 6.06 |
| Ray Jarvis | Royals | 6.70 |
| Gary Bell | Bay Sox | 7.19 |