| Name | Name | ERA |
| Paul Lindblad* | | 2.23 |
| Al Fitzmorris | Totems | 2.29 |
| Goose Gossage | Sparkplugs | 2.31 |
| Catfish Hunter | Hot Rods | 2.59 |
| Randy Jones* | Mets | 2.60 |
| Frank Tanana* | Hot Rods | 2.62 |
| Bill Lee* | Stingers | 2.73 |
| Tom Seaver | Gladiators | 2.74 |
| John Candelaria* | Prince Archbishops | 2.76 |
| Bruce Kison | Mets | 2.79 |
| Jon Matlack* | Royals | 2.85 |
| Jim Palmer | Royals | 2.90 |
| Burt Hooton | Royals | 3.00 |
| Paul Splittorff* | Dragons | 3.01 |
| Marty Pattin | Dragons | 3.03 |
| Woodie Fryman* | Angels | 3.04 |
| Gaylord Perry | Totems | 3.12 |
| Rick Reuschel | Angels | 3.13 |
| Steve Renko | Lions | 3.15 |
| Wilbur Wood* | Sparkplugs | 3.17 |
| Bert Blyleven | Gladiators | 3.19 |
| Dick Bosman | Lions | 3.26 |
| Jerry Reuss* | Sparkplugs | 3.27 |
| Steve Busby | Totems | 3.34 |
| Ed Figueroa | Cruisers | 3.35 |
| Bill Hands | Elephants | 3.38 |
| Fergie Jenkins | Sparkplugs | 3.41 |
| Jim Hughes | Hot Rods | 3.45 |
| Nolan Ryan | Dragons | 3.46 |
| Pedro Borbon | Angels | 3.52 |
| Dan Warthen* | Gladiators | 3.52 |
| Larry Christenson | Hot Rods | 3.53 |
| Ed Halicki | Barons | 3.54 |
| Dennis Eckersley | Schema Busters | 3.55 |
| Don Sutton | Monarchs | 3.55 |
| Pete Broberg | Prince Archbishops | 3.64 |
| Steve Stone | Cruisers | 3.66 |
| Ron Reed | Monarchs | 3.68 |
| Rick Wise | Prince Archbishops | 3.70 |
| John Montefusco | Sparkplugs | 3.73 |
| Dennis Leonard | Seals | 3.75 |
| J.R. Richard | Seals | 3.76 |
| Glenn Abbott | Schema Busters | 3.79 |
| John Curtis* | Colts | 3.87 |
| Don Gullett* | Elephants | 3.87 |
| Mike Caldwell* | Mets | 3.90 |
| Doyle Alexander | Elephants | 3.90 |
| Lynn McGlothen | Angels | 3.91 |
| Steve Hargan | Mets | 3.93 |
| Bob Forsch | Prince Archbishops | 3.93 |
| Gary Nolan | Dragons | 3.95 |
| Claude Osteen* | Schema Busters | 3.95 |
| Bill Bonham | Angels | 3.98 |
| Vern Ruhle | Monarchs | 4.01 |
| Ray Corbin | Seals | 4.05 |
| Larry Gura* | Royals | 4.07 |
| Dave Goltz | Seals | 4.09 |
| Clay Carroll | Fortress | 4.13 |
| Rollie Fingers | Hot Rods | 4.13 |
| Steve Rogers | Mets | 4.16 |
| Pat Dobson | Stingers | 4.18 |
| Joe McIntosh | Fortress | 4.23 |
| Andy Messersmith | Fortress | 4.26 |
| Mike Torrez | Prince Archbishops | 4.27 |
| Steve Foucault | Fortress | 4.28 |
| Reggie Cleveland | Mets | 4.29 |
| Dock Ellis | Monarchs | 4.29 |
| Lindy McDaniel | Totems | 4.36 |
| Bill Singer | Lions | 4.39 |
| Jim Barr | Fortress | 4.42 |
| Rudy May* | Gladiators | 4.42 |
| Carl Morton | Schema Busters | 4.51 |
| Ken Holtzman* | Barons | 4.53 |
| Phil Niekro | Lions | 4.57 |
| Jim Rooker* | Royals | 4.61 |
| Jim Colborn | Dragons | 4.66 |
| Jerry Koosman* | Mets | 4.66 |
| Stan Bahnsen | Lions | 4.70 |
| Ken Forsch | Barons | 4.70 |
| Randy Tate | Stingers | 4.71 |
| Larry Demery | Seals | 4.76 |
| Fritz Peterson* | Stingers | 4.78 |
| Jim Kaat* | Totems | 4.81 |
| Doug Rau* | Dragons | 4.87 |
| Fred Norman* | Elephants | 4.89 |
| Ray Burris | Schema Busters | 4.96 |
| Tom Underwood* | Elephants | 4.97 |
| Jim Lonborg | Monarchs | 4.98 |
| Mickey Lolich* | Totems | 5.09 |
| Hank Webb | Colts | 5.10 |
| Steve Carlton* | Colts | 5.14 |
| Dave Freisleben | Prince Archbishops | 5.15 |
| Luis Tiant | Gladiators | 5.22 |
| Wayne Twitchell | Fortress | 5.23 |
| Bill Travers* | Colts | 5.24 |
| Ken Brett* | Seals | 5.27 |
| Doug Konieczny | Stingers | 5.28 |
| Jack Billingham | Cruisers | 5.36 |
| Vida Blue* | Beavers | 5.41 |
| Eric Raich | Seals | 5.42 |
| Dave Roberts* | Barons | 5.45 |
| Roric Harrison | Colts | 5.46 |
| Roger Moret* | Monarchs | 5.46 |
| Lerrin LaGrow | Stingers | 5.46 |
| Dennis Blair | Barons | 5.47 |
| Doc Medich | Cruisers | 5.50 |
| Pat Darcy | Fortress | 5.58 |
| Jim Perry | Angels | 5.61 |
| Rick Rhoden | Colts | 5.69 |
| Tom Walker | Beavers | 5.72 |
| Jim Bibby | Fortress | 5.72 |
| Vic Albury* | Cruisers | 5.84 |
| Andy Hassler* | Colts | 5.89 |
| Don Hood* | Barons | 5.95 |
| John Denny | Elephants | 5.99 |
| Larry Dierker | Monarchs | 6.08 |
| Joe Coleman | Lions | 6.09 |
| Pete Falcone* | Beavers | 6.10 |
| Jim Slaton | Beavers | 6.11 |
| Jackie Brown | | 6.19 |
| Dan Spillner | Beavers | 6.29 |
| Ross Grimsley* | Prince Archbishops | 6.95 |
| Dave McNally* | Stingers | 7.05 |
| Bob Gibson | Beavers | 7.54 |
| Nelson Briles | Elephants | 8.01 |