| Name | Name | ERA |
| Mark Fidrych | Totems | 1.92 |
| Randy Jones* | Mets | 2.02 |
| Francisco Barrios | Mets | 2.17 |
| Phil Niekro | Lions | 2.22 |
| Jerry Koosman* | Mets | 2.26 |
| Nolan Ryan | Dragons | 2.34 |
| Steve Rogers | Mets | 2.46 |
| Ron Reed | Monarchs | 2.48 |
| Rudy May* | Gladiators | 2.50 |
| Tom Seaver | Gladiators | 2.52 |
| Harry Rasmussen | Barons | 2.54 |
| Mike Torrez | Prince Archbishops | 2.62 |
| John Hiller* | Gladiators | 2.63 |
| Rollie Fingers | Elephants | 2.68 |
| Steve Renko | Lions | 2.72 |
| Jon Matlack* | Royals | 2.85 |
| Bert Blyleven | Gladiators | 2.90 |
| Jim Palmer | Royals | 2.91 |
| Vida Blue* | Beavers | 2.91 |
| Rick Wise | Prince Archbishops | 2.93 |
| Frank Tanana* | Barons | 2.96 |
| Andy Hassler* | Colts | 2.99 |
| John Montefusco | Sparkplugs | 3.03 |
| Bill Campbell | Royals | 3.06 |
| Jim Willoughby | Mets | 3.08 |
| Bill Bonham | Angels | 3.08 |
| Reggie Cleveland | Schema Busters | 3.11 |
| John Candelaria* | Prince Archbishops | 3.16 |
| Jim Barr | Fortress | 3.18 |
| Dave Roberts* | Barons | 3.22 |
| Gaylord Perry | Totems | 3.24 |
| Bruce Kison | Mets | 3.24 |
| Wayne Garland | Elephants | 3.26 |
| Butch Metzger | Totems | 3.27 |
| Don Gullett* | Elephants | 3.29 |
| Al Fitzmorris | Totems | 3.30 |
| Pat Zachry | Beavers | 3.35 |
| Dennis Leonard | Seals | 3.36 |
| Burt Hooton | Royals | 3.39 |
| Ed Figueroa | Surf | 3.43 |
| Tom Underwood* | Surf | 3.44 |
| Ed Halicki | Surf | 3.48 |
| John Denny | Elephants | 3.51 |
| Fergie Jenkins | Sparkplugs | 3.52 |
| Steve Carlton* | Colts | 3.54 |
| Jim Rooker* | | 3.56 |
| Joe Coleman | Lions | 3.59 |
| Pat Dobson | Stingers | 3.62 |
| Paul Hartzell | Elephants | 3.63 |
| Don Carrithers | Lions | 3.68 |
| Rick Reuschel | Angels | 3.68 |
| Jim Kern | Cruisers | 3.70 |
| Catfish Hunter | Surf | 3.71 |
| Doug Rau* | Dragons | 3.73 |
| Dave Freisleben | Prince Archbishops | 3.87 |
| Bill Travers* | Colts | 3.87 |
| Ken Holtzman* | Barons | 3.90 |
| Jim Colborn | Dragons | 3.90 |
| Bob Forsch | Prince Archbishops | 3.93 |
| Paul Lindblad* | Fortress | 3.97 |
| J. R. Richard | Seals | 3.97 |
| Dave Lemanczyk | Schema Busters | 3.99 |
| Dock Ellis | Monarchs | 4.01 |
| Dennis Eckersley | Schema Busters | 4.01 |
| Ray Burris | Schema Busters | 4.02 |
| Luis Tiant | Gladiators | 4.03 |
| Brent Strom* | Surf | 4.04 |
| Gary Nolan | Dragons | 4.04 |
| Carl Morton | Schema Busters | 4.06 |
| Joaquin Andujar | Mets | 4.10 |
| Craig Swan | Schema Busters | 4.10 |
| Woodie Fryman* | Angels | 4.11 |
| Sid Monge* | Lions | 4.14 |
| Bill Lee* | Stingers | 4.16 |
| Andy Messersmith | Fortress | 4.16 |
| Jerry Augustine* | Sparkplugs | 4.16 |
| Gary Ross | Dragons | 4.20 |
| Dave Goltz | Seals | 4.21 |
| Lynn McGlothen | Angels | 4.26 |
| Fred Norman* | Elephants | 4.29 |
| Rick Jones* | Cruisers | 4.31 |
| John D'Acquisto | Stingers | 4.32 |
| Pete Redfern | Sparkplugs | 4.33 |
| Mickey Lolich* | Totems | 4.34 |
| Don Sutton | Monarchs | 4.37 |
| Doug Bird | Angels | 4.38 |
| Rich Gossage | Sparkplugs | 4.38 |
| Jerry Reuss* | Sparkplugs | 4.40 |
| Steve Luebber | Fortress | 4.42 |
| Jim Slaton | Beavers | 4.46 |
| Jack Billingham | Cruisers | 4.47 |
| Jim Umbarger* | Stingers | 4.49 |
| Bill Singer | | 4.54 |
| Ken Brett* | Seals | 4.56 |
| Ray Bare | Cruisers | 4.58 |
| Jim Kaat* | Totems | 4.59 |
| Doyle Alexander | Elephants | 4.61 |
| Rick Waits* | Stingers | 4.63 |
| Charlie Hough | Prince Archbishops | 4.63 |
| Pete Vuckovich | Stingers | 4.66 |
| Stan Bahnsen | Lions | 4.74 |
| Dick Ruthven | Stingers | 4.75 |
| Larry Christenson | Cruisers | 4.76 |
| Nelson Briles | Barons | 4.78 |
| Dick Bosman | Lions | 4.86 |
| Jim Lonborg | Monarchs | 4.87 |
| Pete Falcone* | Beavers | 4.87 |
| Dan Warthen* | Gladiators | 4.91 |
| Dick Pole | Beavers | 4.93 |
| Ross Grimsley* | Prince Archbishops | 5.02 |
| Rick Rhoden | Colts | 5.08 |
| Tommy Boggs | Colts | 5.09 |
| Don Stanhouse | Fortress | 5.23 |
| John Curtis* | Colts | 5.54 |
| Tommy John* | Seals | 5.56 |
| Paul Splittorff* | Cruisers | 5.60 |
| Vern Ruhle | Monarchs | 5.64 |
| Larry Dierker | Monarchs | 5.70 |
| Don Kirkwood | Elephants | 5.79 |
| Jim Bibby | Fortress | 5.81 |
| Paul Mitchell | Colts | 5.96 |
| Doc Medich | Cruisers | 6.02 |
| Jim Hughes | Stingers | 6.20 |
| Dan Spillner | Beavers | 6.37 |
| Mike Cosgrove* | Beavers | 7.91 |