STAT-Strikeouts -- All players in database
Regular season
| Relief |
| Name | Name | K |
| Nolan Ryan | Dragons | 96 |
| Tom Seaver | Gladiators | 90 |
| Jerry Koosman* | Mets | 83 |
| Frank Tanana* | Barons | 69 |
| Dennis Eckersley | Schema Busters | 68 |
| Bert Blyleven | Gladiators | 59 |
| J. R. Richard | Seals | 57 |
| Dennis Leonard | Seals | 53 |
| John Candelaria* | Prince Archbishops | 52 |
| Andy Messersmith | Fortress | 46 |
| Dick Ruthven | Stingers | 45 |
| Catfish Hunter | Surf | 43 |
| Vida Blue* | Beavers | 43 |
| Ed Halicki | Surf | 42 |
| John Montefusco | Sparkplugs | 41 |
| Craig Swan | Schema Busters | 41 |
| Don Sutton | Monarchs | 40 |
| Pat Zachry | Beavers | 39 |
| Steve Carlton* | Colts | 39 |
| Luis Tiant | Gladiators | 39 |
| Wilbur Wood* | Sparkplugs | 39 |
| Dave Goltz | Seals | 38 |
| Ken Brett* | Seals | 38 |
| Jon Matlack* | Royals | 37 |
| Phil Niekro | Lions | 36 |
| Bill Bonham | Angels | 36 |
| Rick Reuschel | Angels | 36 |
| Ron Reed | Monarchs | 36 |
| Mike Torrez | Prince Archbishops | 36 |
| Gaylord Perry | Totems | 36 |
| Pete Falcone* | Beavers | 35 |
| Rick Waits* | Stingers | 35 |
| Rollie Fingers | Elephants | 35 |
| Bill Campbell | Royals | 35 |
| Doug Bird | Angels | 35 |
| Jerry Reuss* | Sparkplugs | 34 |
| Larry Dierker | Monarchs | 34 |
| Fergie Jenkins | Sparkplugs | 34 |
| Jim Kern | Cruisers | 33 |
| Mark Fidrych | Totems | 33 |
| Wayne Garland | Elephants | 33 |
| Jim Palmer | Royals | 33 |
| Jim Umbarger* | Stingers | 33 |
| Jim Colborn | Dragons | 33 |
| Jim Lonborg | Monarchs | 31 |
| Steve Rogers | Mets | 31 |
| Butch Metzger | Totems | 31 |
| Rick Wise | Prince Archbishops | 31 |
| Gary Nolan | Dragons | 30 |
| Reggie Cleveland | Schema Busters | 30 |
| John Hiller* | Gladiators | 30 |
| Jim Hughes | Stingers | 30 |
| Jack Billingham | Cruisers | 29 |
| Bruce Kison | Mets | 29 |
| Jim Rooker* | | 29 |
| Bill Travers* | Colts | 29 |
| Pat Dobson | Stingers | 28 |
| Burt Hooton | Royals | 27 |
| Tom Underwood* | Surf | 27 |
| Lynn McGlothen | Angels | 27 |
| Don Stanhouse | Fortress | 27 |
| Randy Jones* | Mets | 27 |
| Dave LaRoche* | Royals | 27 |
| Ed Figueroa | Surf | 27 |
| Rick Rhoden | Colts | 26 |
| Woodie Fryman* | Angels | 26 |
| Gary Ross | Dragons | 26 |
| Mickey Lolich* | Totems | 25 |
| Brent Strom* | Surf | 25 |
| Charlie Hough | Prince Archbishops | 24 |
| Mark Littell | Surf | 24 |
| Don Gullett* | Elephants | 23 |
| Fred Norman* | Elephants | 23 |
| Rich Gossage | Sparkplugs | 23 |
| Dave Roberts* | Barons | 23 |
| Steve Renko | Lions | 23 |
| Bill Singer | | 23 |
| Carl Morton | Schema Busters | 22 |
| Mike Caldwell* | Mets | 22 |
| Bob Forsch | Prince Archbishops | 22 |
| Dan Larson | Barons | 22 |
| Ray Bare | Cruisers | 22 |
| Ken Holtzman* | Barons | 22 |
| Tommy John* | Seals | 21 |
| Jim Bibby | Fortress | 21 |
| Steve Dunning | Lions | 21 |
| Ray Burris | Schema Busters | 20 |
| Bruce Sutter | Surf | 20 |
| Doc Medich | Cruisers | 20 |
| John Denny | Elephants | 20 |
| Paul Mitchell | Colts | 20 |
| Paul Splittorff* | Cruisers | 20 |
| Rudy May* | Gladiators | 20 |
| Adrian Devine | Elephants | 19 |
| Steve Stone | Cruisers | 19 |
| Gene Garber | Lions | 19 |
| Jim Kaat* | Totems | 19 |
| Wayne Twitchell | Fortress | 19 |
| Larry Demery | Seals | 19 |
| Dave Hamilton* | Cruisers | 19 |
| Mike Flanagan* | Royals | 19 |
| Don Kirkwood | Elephants | 19 |
| Jim Slaton | Beavers | 19 |
| Andy Hassler* | Colts | 19 |
| Rawly Eastwick | Angels | 18 |
| Gary Lavelle* | Totems | 18 |
| Kent Tekulve | Surf | 18 |
| Dan Warthen* | Gladiators | 18 |
| Dave Freisleben | Prince Archbishops | 18 |
| Al Fitzmorris | Totems | 18 |
| Doyle Alexander | Elephants | 18 |
| Dave Pagan | Beavers | 18 |
| Joe Niekro | Royals | 17 |
| Dock Ellis | Monarchs | 17 |
| Danny Frisella | Gladiators | 17 |
| Doug Rau* | Dragons | 16 |
| Harry Rasmussen | Barons | 16 |
| Skip Lockwood | Royals | 16 |
| Bill Laxton* | Cruisers | 16 |
| Sid Monge* | Lions | 16 |
| Nelson Briles | Barons | 16 |
| Joe Coleman | Lions | 16 |
| Tom Murphy | Sparkplugs | 16 |
| Tippy Martinez* | Surf | 16 |
| Darold Knowles* | Beavers | 15 |
| Paul Reuschel | Cruisers | 15 |
| Jim Barr | Fortress | 15 |
| Larry Christenson | Cruisers | 15 |
| Mike Cosgrove* | Beavers | 15 |
| Rick Jones* | Cruisers | 15 |
| Stan Thomas | Dragons | 15 |
| Dave Giusti | Monarchs | 14 |
| Ken Forsch | Surf | 14 |
| Bob Apodaca | Angels | 14 |
| Bill Lee* | Stingers | 14 |
| Dick Pole | Beavers | 14 |
| Sparky Lyle* | Barons | 14 |
| Dick Tidrow | Elephants | 14 |
| Ross Grimsley* | Prince Archbishops | 14 |
| Tommy Boggs | Colts | 14 |
| Steve Mingori* | Monarchs | 14 |
| Ken Frailing* | Totems | 13 |
| Joaquin Andujar | Mets | 13 |
| Don Carrithers | Lions | 13 |
| Vern Ruhle | Monarchs | 13 |
| Stan Bahnsen | Lions | 13 |
| Dan Spillner | Beavers | 12 |
| Dyar Miller | Dragons | 12 |
| Pete Redfern | Sparkplugs | 12 |
| Paul Hartzell | Elephants | 12 |
| Mike Marshall | Sparkplugs | 12 |
| Ron Schueler | Prince Archbishops | 11 |
| Bo McLaughlin | Surf | 11 |
| Mike Norris | Colts | 11 |
| Dick Drago | Barons | 11 |
| Mike Bacsik | Cruisers | 11 |
| Eduardo Rodriguez | Colts | 11 |
| Pedro Borbon | Angels | 10 |
| Al Hrabosky* | Angels | 10 |
| Tom Griffin | Seals | 10 |
| Mike Garman | Stingers | 9 |
| Mike Wallace* | Seals | 9 |
| Joe Sambito* | Seals | 9 |
| Jerry Johnson | Colts | 9 |
| Rick Sawyer | Fortress | 9 |
| Pete Vuckovich | Stingers | 9 |
| Glenn Abbott | Schema Busters | 9 |
| Dick Bosman | Lions | 9 |
| Paul Lindblad* | Fortress | 9 |
| Steve Luebber | Fortress | 9 |
| Steve Foucault | Seals | 9 |
| Marty Pattin | Dragons | 9 |
| Elias Sosa | Lions | 9 |
| Roger Moret* | Monarchs | 8 |
| Buddy Schultz* | Prince Archbishops | 8 |
| Manny Sarmiento | Seals | 8 |
| Rob Dressler | Monarchs | 8 |
| John Curtis* | Colts | 8 |
| Chip Lang | Colts | 8 |
| Dave Tomlin* | Seals | 8 |
| Clay Carroll | Fortress | 8 |
| Don Hood* | Monarchs | 8 |
| Dennis Martinez | Seals | 8 |
| Larry Gura* | Royals | 8 |
| Jerry Augustine* | Sparkplugs | 8 |
| Frank LaCorte | Dragons | 7 |
| Dave Heaverlo | Barons | 7 |
| Randy Moffitt | Schema Busters | 7 |
| Frank Riccelli* | Gladiators | 7 |
| Dale Murray | Schema Busters | 7 |
| Tom Buskey | Fortress | 7 |
| John Verhoeven | Colts | 7 |
| Oscar Zamora | Angels | 6 |
| Charlie Williams | Schema Busters | 6 |
| Paul Siebert* | Angels | 6 |
| Wayne Granger | Barons | 6 |
| Fred Scherman* | Beavers | 6 |
| Jim Willoughby | Mets | 6 |
| Francisco Barrios | Mets | 6 |
| Terry Forster* | Gladiators | 6 |
| Dave Lemanczyk | Schema Busters | 6 |
| Bill Castro | Royals | 6 |
| Grant Jackson* | Beavers | 6 |
| Pablo Torrealba* | Sparkplugs | 5 |
| Stan Wall* | Mets | 5 |
| Will McEnaney* | Stingers | 5 |
| John D'Acquisto | Stingers | 5 |
| Tug McGraw* | Dragons | 5 |
| Gene Pentz | Monarchs | 5 |
| Joe Kerrigan | Fortress | 5 |
| Ken Kravec* | Monarchs | 5 |
| Jackie Brown | Barons | 5 |
| Steve Grilli | Totems | 5 |
| Scott McGregor* | Surf | 5 |
| Joe Decker | Beavers | 5 |
| Jim Brewer* | Barons | 5 |
| Bruce Dal Canton | | 4 |
| Santo Alcala | Dragons | 4 |
| Rick Langford | Surf | 4 |
| Jim Todd | Gladiators | 4 |
| Mickey Scott* | Colts | 4 |
| Tom Bruno | Seals | 4 |
| Pete Broberg | Prince Archbishops | 4 |
| Al Downing* | Elephants | 3 |
| Bob Moose | Sparkplugs | 3 |
| Mike Proly | Colts | 3 |
| Jim Crawford* | Barons | 3 |
| Eddie Bane* | Schema Busters | 3 |
| Tom Burgmeier* | Dragons | 3 |
| Ken Sanders | Sparkplugs | 3 |
| Mark Lemongello | Surf | 2 |
| Rich Folkers* | Totems | 2 |
| Tom House* | Gladiators | 2 |
| Mike Cuellar* | Stingers | 2 |
| Vic Albury* | Cruisers | 2 |
| Tom Johnson | Lions | 2 |
| Steve Hargan | Mets | 2 |
| Ramon Hernandez* | Totems | 2 |
| Max Leon | Barons | 1 |
| Alan Foster | Schema Busters | 1 |
| Bill Greif | Schema Busters | 1 |
| Dennis Lewallyn | Totems | 0 |
| Gil Rondon | Lions | 0 |
| Jesse Jefferson | Beavers | 0 |
| Ed Glynn* | Elephants | 0 |