| Name | Name | ERA |
| Ron Guidry* | Mets | 2.53 |
| Don Hood* | Monarchs | 2.58 |
| Bill Bonham | Angels | 2.75 |
| Joe Coleman | Lions | 2.77 |
| Bert Blyleven | Gladiators | 2.95 |
| Rick Waits* | Stingers | 3.02 |
| Nolan Ryan | Flyers | 3.04 |
| Phil Niekro | Lions | 3.14 |
| Lary Sorensen | Surf | 3.19 |
| Doyle Alexander | Elephants | 3.21 |
| Bob Stanley | Lions | 3.22 |
| Mike Flanagan* | Royals | 3.24 |
| Dave Goltz | Seals | 3.26 |
| John Urrea | Royals | 3.34 |
| Steve Rogers | Mets | 3.40 |
| Charlie Hough | Prince Archbishops | 3.41 |
| Joe Niekro | Royals | 3.43 |
| Marty Pattin | Flyers | 3.43 |
| Steve Carlton* | Colts | 3.48 |
| Don Gullett* | Elephants | 3.48 |
| Mike Paxton | Cruisers | 3.49 |
| Dennis Eckersley | Schema Busters | 3.50 |
| Dennis Leonard | Seals | 3.51 |
| Joaquin Andujar | Mets | 3.54 |
| John Candelaria* | Prince Archbishops | 3.54 |
| J.R. Richard | Seals | 3.57 |
| Jerry Koosman* | Mets | 3.59 |
| Don Sutton | Monarchs | 3.62 |
| Dave Rozema | Barons | 3.64 |
| Tom Seaver | Gladiators | 3.65 |
| Jim Palmer | Royals | 3.65 |
| Burt Hooton | Royals | 3.69 |
| Pete Vuckovich | Stingers | 3.70 |
| Rick Reuschel | Angels | 3.73 |
| Luis Tiant | Gladiators | 3.81 |
| Jim Clancy | Flyers | 3.83 |
| Bob Forsch | Prince Archbishops | 3.84 |
| Mark Lemongello | Surf | 3.86 |
| Jesse Jefferson | Beavers | 3.87 |
| Doug Rau* | Flyers | 3.87 |
| Fernando Arroyo | Stingers | 3.89 |
| Moose Haas | Lions | 3.94 |
| Gaylord Perry | Angels | 4.00 |
| Ken Kravec* | Monarchs | 4.08 |
| Ed Figueroa | Surf | 4.11 |
| Doc Medich | Cruisers | 4.12 |
| Mike Torrez | Prince Archbishops | 4.19 |
| Ed Halicki | Surf | 4.20 |
| Dennis Martinez | Seals | 4.21 |
| Larry Christenson | Cruisers | 4.22 |
| Paul Hartzell | Elephants | 4.28 |
| John Montefusco | Sparkplugs | 4.31 |
| Rudy May* | Gladiators | 4.32 |
| Don Stanhouse | Fortress | 4.37 |
| Paul Thormodsgard | Stingers | 4.40 |
| Rick Langford | Surf | 4.40 |
| Bill Lee* | Stingers | 4.41 |
| Doug Bird | Angels | 4.45 |
| Jim Slaton | Beavers | 4.48 |
| Fred Norman* | Elephants | 4.48 |
| Diego Segui | Totems | 4.54 |
| Don Aase | Sparkplugs | 4.58 |
| Bob Knepper* | Fortress | 4.60 |
| Bob Lacey* | Fortress | 4.65 |
| Mike Krukow | Gladiators | 4.70 |
| Paul Splittorff* | Cruisers | 4.72 |
| Pete Falcone* | Beavers | 4.76 |
| Steve Grilli | Totems | 4.77 |
| Eric Rasmussen | Barons | 4.79 |
| Tommy John* | Seals | 4.79 |
| Jim Colborn | Sparkplugs | 4.80 |
| Jerry Augustine* | Flyers | 4.87 |
| Vida Blue* | Beavers | 4.90 |
| Francisco Barrios | Mets | 4.91 |
| Jerry Garvin* | Barons | 4.91 |
| Stan Bahnsen | Lions | 4.95 |
| Dale Murray | Schema Busters | 4.98 |
| Fergie Jenkins | Sparkplugs | 4.98 |
| Reggie Cleveland | Schema Busters | 5.00 |
| Dave Lemanczyk | Schema Busters | 5.03 |
| Frank Tanana* | Barons | 5.09 |
| Wayne Garland | Elephants | 5.27 |
| Steve Stone | Cruisers | 5.30 |
| Jack Billingham | Cruisers | 5.31 |
| Ross Grimsley* | Prince Archbishops | 5.32 |
| Bob Owchinko* | Lions | 5.37 |
| Andy Hassler* | Colts | 5.52 |
| Jackie Brown | Colts | 5.54 |
| Bob Shirley* | Beavers | 5.56 |
| Glenn Abbott | Schema Busters | 5.56 |
| Jon Matlack* | Lions | 5.62 |
| Jim Barr | Fortress | 5.63 |
| Rick Rhoden | Colts | 5.65 |
| Dave Roberts* | Barons | 5.67 |
| Jerry Reuss* | Sparkplugs | 5.73 |
| Craig Swan | Schema Busters | 5.74 |
| Jim Bibby | Fortress | 5.79 |
| Geoff Zahn* | Stingers | 5.90 |
| Jim Kaat* | Totems | 6.01 |
| Jim Rooker* | Monarchs | 6.07 |
| Bill Travers* | Colts | 6.08 |
| Andy Messersmith | Fortress | 6.19 |
| Dock Ellis | Monarchs | 6.26 |
| Rick Wise | Prince Archbishops | 6.34 |
| Pat Zachry | Beavers | 6.53 |
| Butch Metzger | Totems | 6.57 |
| Nino Espinosa | Schema Busters | 6.71 |
| Wayne Twitchell | Fortress | 6.79 |
| Jim Lonborg | Monarchs | 6.82 |
| Pete Redfern | Sparkplugs | 6.86 |
| Randy Lerch* | Angels | 6.89 |
| Doug Bair | Prince Archbishops | 6.89 |
| Al Fitzmorris | Totems | 7.06 |
| John Montague | Totems | 7.39 |
| Larry Demery | Totems | 7.49 |
| Floyd Bannister* | Totems | 7.88 |