| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 5/1/1941 | WES | Aderholt | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Barnicle | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Dickey G | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Giebell | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Gremp | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Hadley | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | McQuillen | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Pearson M | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Robertson | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Susce | Demoted to reserve roster |   |   | Before |
| 5/1/1941 | WES | Wolff | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Bowman J | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Clemensen | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Collins R | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Coscarart | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Fowler | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Gordon S | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Hutchinson F | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Krakauskas | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Piechota | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Russell | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Sanford | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Starr | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Wicker | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Wittig | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | BRK | Wittig | Promoted to active roster |   |   | Before |
| 6/1/1941 | HOO | Fitzsimmons | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | HOO | Fitzsimmons | Promoted to active roster |   |   | Before |
| 6/1/1941 | HOO | Franks | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | HOO | Richmond | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | HOO | Richmond | Promoted to active roster |   |   | Before |
| 6/1/1941 | HOO | Walker H | Demoted to reserve roster |   |   | Before |
| 6/1/1941 | HOO | Walker H | Promoted to active roster |   |   | Before |
| 11/12/2009 | HUD | Brown M | Acquired via trade | WOR |   | After |
| 11/12/2009 | HUD | Derringer | Acquired via trade | WOR |   | After |
| 11/12/2009 | HUD | Etten | Traded away | WOR |   | After |
| 11/12/2009 | HUD | Grace | Traded away | WOR |   | After |
| 11/12/2009 | HUD | Grove | Acquired via trade | WOR |   | After |
| 11/12/2009 | HUD | Lupien 1942 | Acquired via trade | WOR |   | After |
| 11/12/2009 | HUD | Thompson | Acquired via trade | WOR |   | After |
| 11/12/2009 | HUD | Trosky | Acquired via trade | WOR |   | After |
| 11/12/2009 | HUD | Warneke | Traded away | WOR |   | After |
| 11/12/2009 | WOR | Brown M | Traded away | HUD |   | After |
| 11/12/2009 | WOR | Derringer | Traded away | HUD |   | After |
| 11/12/2009 | WOR | Etten | Acquired via trade | HUD |   | After |
| 11/12/2009 | WOR | Grace | Acquired via trade | HUD |   | After |
| 11/12/2009 | WOR | Grove | Traded away | HUD |   | After |
| 11/12/2009 | WOR | Lupien 1942 | Traded away | HUD |   | After |
| 11/12/2009 | WOR | Thompson | Traded away | HUD |   | After |
| 11/12/2009 | WOR | Trosky | Traded away | HUD |   | After |
| 11/12/2009 | WOR | Warneke | Acquired via trade | HUD |   | After |
| 11/30/2009 | BRK | Desautels | Traded away | WES |   | After |
| 11/30/2009 | BRK | Johnson E | Acquired via trade | WES |   | After |
| 11/30/2009 | BRK | McGee | Acquired via trade | WES |   | After |
| 11/30/2009 | BRK | Wagner C | Acquired via trade | SOU |   | After |
| 11/30/2009 | CHI | DiMaggio V | Traded away | ROC |   | After |
| 11/30/2009 | CHI | Greenberg | Acquired via trade | ROC |   | After |
| 11/30/2009 | CHI | Ross B | Traded away | ROC |   | After |
| 11/30/2009 | HOO | Brown Jumbo | Acquired via trade | RIV |   | After |
| 11/30/2009 | HOO | Fitzsimmons | Acquired via trade | RIV |   | After |
| 11/30/2009 | SCH | Blanton | Traded away | WES |   | After |
| 11/30/2009 | WES | Beck | Traded away | BAL |   | After |
| 11/30/2009 | WES | Berardino | Traded away | BAL |   | After |
| 11/30/2009 | WES | Blanton | Acquired via trade | SCH |   | After |
| 11/30/2009 | WES | Desautels | Acquired via trade | BRK |   | After |
| 11/30/2009 | WES | Johnson E | Traded away | BRK |   | After |
| 11/30/2009 | WES | McGee | Traded away | BRK |   | After |
| 11/30/2009 | WES | Moore T | Acquired via trade | RIV |   | After |
| 11/30/2009 | WES | West M | Acquired via trade | BAL |   | After |
| 2/6/2010 | WES | Bruner | Traded away | SOU |   | After |
| 2/6/2010 | WES | Dickey G | Acquired via trade | SOU |   | After |
| 2/6/2010 | WES | Giuliani | Traded away | SOU |   | After |
| 2/6/2010 | WES | Harder | Acquired via trade | MAU |   | After |
| 2/6/2010 | WES | Hughson | Traded away | MAU |   | After |
| 2/6/2010 | WES | Murtaugh | Acquired via trade | MAU |   | After |
| 2/6/2010 | WOR | Brown Jimmy | Acquired via trade | SOU |   | After |
| 2/6/2010 | WOR | Gehringer | Traded away | SOU |   | After |
| 2/6/2010 | WOR | Vaughan A | Acquired via trade | SOU |   | After |
| 2/7/2010 | HOO | Giebell | Traded away | WES |   | After |
| 2/7/2010 | HOO | Glossop 1942 | Traded away | WES |   | After |
| 2/7/2010 | HOO | Lodigiani | Acquired via trade | WES |   | After |
| 2/7/2010 | HOO | McCarthy | Traded away | WES |   | After |
| 2/7/2010 | HOO | McQuillen | Traded away | WES |   | After |
| 2/7/2010 | HOO | Pearson M | Traded away | WES |   | After |
| 2/7/2010 | HOO | Salveson 1943 | Acquired via trade | WES |   | After |
| 2/7/2010 | HOO | Weatherly | Acquired via trade | WES |   | After |
| 2/7/2010 | WES | Giebell | Acquired via trade | HOO |   | After |
| 2/7/2010 | WES | Glossop 1942 | Acquired via trade | HOO |   | After |
| 2/7/2010 | WES | Lodigiani | Traded away | HOO |   | After |
| 2/7/2010 | WES | McCarthy | Acquired via trade | HOO |   | After |
| 2/7/2010 | WES | McQuillen | Acquired via trade | HOO |   | After |
| 2/7/2010 | WES | Pearson M | Acquired via trade | HOO |   | After |
| 2/7/2010 | WES | Salveson 1943 | Traded away | HOO |   | After |
| 2/7/2010 | WES | Weatherly | Traded away | HOO |   | After |
| 2/12/2010 | SCH | Camilli | Acquired via trade | WES |   | After |
| 2/12/2010 | SCH | Hadley | Traded away | WES |   | After |
| 2/12/2010 | SCH | Newhouser | Traded away | WES |   | After |
| 2/12/2010 | SCH | Ruffing | Acquired via trade | WES |   | After |
| 2/12/2010 | SCH | Siebert | Traded away | WES |   | After |
| 2/12/2010 | WES | Camilli | Traded away | SCH |   | After |
| 2/12/2010 | WES | Hadley | Acquired via trade | SCH |   | After |
| 2/12/2010 | WES | Newhouser | Acquired via trade | SCH |   | After |
| 2/12/2010 | WES | Ruffing | Traded away | SCH |   | After |
| 2/12/2010 | WES | Siebert | Acquired via trade | SCH |   | After |
| 2/21/2010 | WES | Chase | Acquired via trade | MAU |   | After |
| 2/21/2010 | WES | Garms | Acquired via trade | MAU |   | After |
| 2/21/2010 | WES | Goodman | Traded away | MAU |   | After |
| 2/21/2010 | WES | Lucadello | Traded away | MAU |   | After |
| 3/24/2010 | WES | Bell | Acquired via trade | SOU |   | After |
| 3/24/2010 | WES | Dickman | Traded away | SOU |   | After |
| 3/28/2010 | SCH | Beckmann | Acquired via trade | BAL |   | After |
| 3/28/2010 | SCH | Riggs | Traded away | BAL |   | After |