| Name | Name | ERA |
| Dizzy Trout | Larks | 2.13 |
| Vic Raschi | Royal Giants | 2.39 |
| Ken Raffensberger* | Blues | 2.40 |
| Bob Kelly | Larks | 2.54 |
| Robin Roberts | Muck Dogs | 2.58 |
| Eddie Lopat* | Thunderbolts | 2.83 |
| Fred Hutchinson | Thunderbolts | 2.84 |
| Warren Spahn* | Stampers | 2.87 |
| Ned Garver | Larks | 2.88 |
| Al Brazle* | Royal Giants | 2.90 |
| Ken Holcombe | Grays | 2.91 |
| Mickey McDermott* | Stampers | 2.92 |
| Bob Hooper | Larks | 2.94 |
| Larry Jansen | Royal Giants | 3.03 |
| Bob Rush | Carp | 3.25 |
| Saul Rogovin | Royal Giants | 3.26 |
| Sal Maglie | Stampers | 3.27 |
| Max Lanier* | Grays | 3.29 |
| Bob Feller | Rugrats | 3.39 |
| Chuck Stobbs* | Larks | 3.44 |
| Connie Marrero | Tigers | 3.45 |
| Don Newcombe | Muck Dogs | 3.46 |
| Bob Porterfield | Stampers | 3.46 |
| Mike Garcia | Grays | 3.48 |
| Ewell Blackwell | Royal Giants | 3.53 |
| Marlin Stuart | Carp | 3.54 |
| Mel Parnell* | Tigers | 3.57 |
| Vern Law | Arsenal | 3.60 |
| Gerry Staley | Clowns | 3.60 |
| Early Wynn | Rugrats | 3.61 |
| Jim Hearn | Grays | 3.63 |
| Bob Lemon | Carp | 3.81 |
| Allie Reynolds | Hawks | 3.82 |
| Sam Zoldak* | Blues | 3.91 |
| Bubba Church | Arsenal | 3.96 |
| Herm Wehmeier | Clowns | 3.97 |
| Murry Dickson | Hawks | 4.00 |
| Max Surkont | Clowns | 4.07 |
| Randy Gumpert | Hawks | 4.12 |
| Julio Moreno | Blues | 4.22 |
| Ted Gray* | Grays | 4.24 |
| Bill Wight* | Tigers | 4.25 |
| Ralph Branca | Rugrats | 4.31 |
| Russ Meyer | Hawks | 4.35 |
| Bob Cain* | Clowns | 4.36 |
| Billy Pierce* | Arsenal | 4.46 |
| Frank Hiller | Aces | 4.66 |
| Chet Nichols* | Hawks | 4.70 |
| Tom Poholsky | Muck Dogs | 4.78 |
| Mel Queen | Arsenal | 4.87 |
| Cliff Chambers* | Muck Dogs | 4.94 |
| Johnny Sain | Aces | 4.95 |
| Don Johnson | Aces | 5.96 |
| Joe Dobson | Carp | 6.32 |
| Willie Ramsdell | Blues | 6.40 |
| Duane Pillette | Aces | 6.44 |