| Name | Name | ERA |
| Warren Hacker | Stampers | 1.84 |
| Bob Lemon | Carp | 1.90 |
| Bob Rush | Carp | 2.03 |
| Curt Simmons* | Larks | 2.26 |
| Joe Black | Thunderbolts | 2.36 |
| Hoyt Wilhelm | Aces | 2.50 |
| Ken Raffensberger* | Blues | 2.51 |
| Turk Lown | Larks | 2.66 |
| Mel Parnell* | Tigers | 2.67 |
| Karl Drews | Rugrats | 2.67 |
| Joe Dobson | Carp | 2.72 |
| Ned Garver | Larks | 2.74 |
| Bobby Shantz* | Stampers | 2.80 |
| Dizzy Trout | Larks | 2.84 |
| Larry Jansen | Royal Giants | 2.86 |
| Gene Bearden* | Aces | 2.87 |
| Ellis Kinder | Blues | 2.90 |
| Gerry Staley | Clowns | 2.90 |
| Carl Erskine | Thunderbolts | 2.93 |
| Harry Perkowski* | Royal Giants | 3.11 |
| Bill Wight* | Tigers | 3.11 |
| Vic Raschi | Arsenal | 3.12 |
| Johnny Klippstein | Rugrats | 3.12 |
| Billy Pierce* | Arsenal | 3.15 |
| Lew Burdette | Rugrats | 3.18 |
| Warren Spahn* | Stampers | 3.21 |
| Spec Shea | Thunderbolts | 3.24 |
| Earl Harrist | Royal Giants | 3.28 |
| Howie Pollet* | Tigers | 3.33 |
| Ray Scarborough | Larks | 3.35 |
| Robin Roberts | Muck Dogs | 3.36 |
| Jim Wilson | Tigers | 3.40 |
| Dave Koslo* | Thunderbolts | 3.40 |
| Bob Porterfield | Stampers | 3.41 |
| Art Houtteman | Arsenal | 3.41 |
| Russ Meyer | Hawks | 3.41 |
| Preacher Roe* | Rugrats | 3.42 |
| Eddie Lopat* | Thunderbolts | 3.43 |
| Sal Maglie | Stampers | 3.47 |
| Ted Wilks | Stampers | 3.50 |
| Ted Gray* | Grays | 3.51 |
| Wilmer Mizell* | Blues | 3.51 |
| Vern Bickford | Aces | 3.53 |
| Murry Dickson | Hawks | 3.57 |
| Marlin Stuart | Carp | 3.61 |
| Billy Hoeft* | Arsenal | 3.63 |
| Satchel Paige | Hawks | 3.64 |
| Harry Byrd | Tigers | 3.68 |
| Ben Wade | Thunderbolts | 3.72 |
| Allie Reynolds | Hawks | 3.73 |
| Jim Hearn | Grays | 3.74 |
| Bob Friend | Clowns | 3.84 |
| Hal Newhouser* | Thunderbolts | 3.86 |
| Frank Hiller | Aces | 3.88 |
| Duane Pillette | Aces | 3.88 |
| Chuck Stobbs* | Larks | 3.90 |
| Marv Grissom | Tigers | 3.94 |
| Bob Feller | Rugrats | 3.95 |
| Mike Garcia | Grays | 3.96 |
| Early Wynn | Rugrats | 3.97 |
| Bob Kuzava* | Muck Dogs | 3.98 |
| Paul Minner* | Stampers | 3.98 |
| Tommy Byrne* | Royal Giants | 4.03 |
| Bob Cain* | Thunderbolts | 4.04 |
| Joe Presko | Aces | 4.07 |
| Johnny Sain | Aces | 4.07 |
| Mickey McDermott* | Clowns | 4.13 |
| Walt Masterson | Larks | 4.16 |
| Billy Loes | Hawks | 4.17 |
| Saul Rogovin | Royal Giants | 4.20 |
| Bob Hooper | Larks | 4.26 |
| Max Surkont | Thunderbolts | 4.26 |
| Ernie Johnson | Arsenal | 4.30 |
| Virgil Trucks | Muck Dogs | 4.31 |
| Max Lanier* | Grays | 4.32 |
| Alex Kellner* | Clowns | 4.33 |
| Cloyd Boyer | Carp | 4.34 |
| Sid Hudson | Arsenal | 4.36 |
| Dick Brodowski | Clowns | 4.38 |
| Bubba Church | Royal Giants | 4.38 |
| Steve Gromek | Grays | 4.50 |
| Johnny Rutherford | Clowns | 4.62 |
| Woody Main | Grays | 4.67 |
| Cal Hogue | Muck Dogs | 4.76 |
| Julio Moreno | Blues | 5.10 |
| Carl Scheib | Hawks | 5.15 |
| Ewell Blackwell | Blues | 5.24 |
| Jim Waugh | Muck Dogs | 5.35 |
| Cliff Chambers* | Muck Dogs | 5.94 |
| Ron Necciai | Muck Dogs | 7.60 |