| Name | Name | ERA |
| Bobby Shantz* | Stampers | 1.49 |
| Tom Brewer | Carp | 2.03 |
| Don Mossi* | Stampers | 2.49 |
| Hersh Freeman | Blues | 2.55 |
| Bob Rush | Carp | 2.57 |
| Don Newcombe | Muck Dogs | 2.63 |
| Jim Davis* | Aces | 2.68 |
| Tom Sturdivant | Muck Dogs | 2.69 |
| Jack Harshman* | Muck Dogs | 2.71 |
| Turk Lown | Larks | 2.74 |
| Early Wynn | Walleye | 2.82 |
| Frank Lary | Thunderbolts | 2.82 |
| Bob Lemon | Carp | 2.84 |
| Bob Friend | Clowns | 3.05 |
| Dick Donovan | Royal Giants | 3.08 |
| Mike Fornieles | Carp | 3.09 |
| Bob Porterfield | Aces | 3.12 |
| Vern Law | Larks | 3.12 |
| Virgil Trucks | Thunderbolts | 3.14 |
| Chuck Stobbs* | Larks | 3.26 |
| Warren Spahn* | Walleye | 3.28 |
| Jim Hearn | Grays | 3.29 |
| Billy Pierce* | Larks | 3.31 |
| Red Munger | Hawks | 3.32 |
| Herb Score* | Walleye | 3.37 |
| Saul Rogovin | Royal Giants | 3.39 |
| Curt Simmons* | Larks | 3.41 |
| Willard Nixon | Blues | 3.45 |
| Sal Maglie | Thunderbolts | 3.45 |
| Roger Craig | Carp | 3.46 |
| Carl Erskine | Clowns | 3.49 |
| Hal Jeffcoat | Clowns | 3.52 |
| Bob Buhl | Walleye | 3.53 |
| Alex Kellner* | Stampers | 3.56 |
| Connie Johnson | Grays | 3.60 |
| Hal Brown | Muck Dogs | 3.64 |
| Don Kaiser | Arsenal | 3.66 |
| Billy Hoeft* | Arsenal | 3.71 |
| Vinegar Bend Mizell* | Blues | 3.73 |
| Jim Wilson | Tigers | 3.77 |
| Don Larsen | Arsenal | 3.80 |
| Al Worthington | Muck Dogs | 3.86 |
| Herm Wehmeier | Thunderbolts | 3.88 |
| Tom Poholsky | Aces | 3.90 |
| Dave Sisler | Blues | 3.94 |
| Art Fowler | Blues | 3.94 |
| Joe Nuxhall* | Grays | 3.97 |
| Murry Dickson | Aces | 3.98 |
| Whitey Ford* | Arsenal | 4.01 |
| Lew Burdette | Walleye | 4.02 |
| Ray Moore | Aces | 4.11 |
| Steve Ridzik | Stampers | 4.11 |
| Gene Conley | Larks | 4.14 |
| Robin Roberts | Muck Dogs | 4.17 |
| Ruben Gomez | Hawks | 4.27 |
| Frank Sullivan | Tigers | 4.35 |
| Brooks Lawrence | Thunderbolts | 4.35 |
| Steve Gromek | Grays | 4.40 |
| Larry Jackson | Stampers | 4.41 |
| Johnny Kucks | Blues | 4.46 |
| Mike Garcia | Grays | 4.49 |
| Paul Foytack | Royal Giants | 4.56 |
| Lou Kretlow | Royal Giants | 4.69 |
| Don Drysdale | Hawks | 4.72 |
| Ray Crone | Clowns | 4.73 |
| Tom Gorman | Hawks | 4.89 |
| Pedro Ramos | Stampers | 4.92 |
| Johnny Antonelli* | Tigers | 5.01 |
| Stu Miller | Carp | 5.01 |
| Ike Delock | Larks | 5.01 |
| Sam Jones | Aces | 5.02 |
| Bob Keegan | Clowns | 5.07 |
| Duke Maas | Royal Giants | 5.15 |
| Camilo Pascual | Tigers | 5.26 |
| Harvey Haddix* | Tigers | 5.40 |
| Johnny Klippstein | Hawks | 5.54 |
| Warren Hacker | Stampers | 5.89 |
| Willard Schmidt | Royal Giants | 5.90 |
| Dick Littlefield* | Hawks | 6.22 |
| Wally Burnette | Grays | 6.26 |
| Art Ditmar | Arsenal | 6.34 |
| Ron Kline | Royal Giants | 6.36 |
| Dean Stone* | Arsenal | 6.95 |
| Erv Palica | Hawks | 7.03 |