| Name | Name | ERA |
| Tom Brewer | Carp | 1.91 |
| Hersh Freeman | Blues | 2.43 |
| Don Mossi* | Stampers | 2.46 |
| Bobby Shantz* | Stampers | 2.47 |
| Jack Harshman* | Muck Dogs | 2.51 |
| Bob Rush | Carp | 2.53 |
| Early Wynn | Walleye | 2.61 |
| Don Newcombe | Muck Dogs | 2.61 |
| Tom Sturdivant | Muck Dogs | 2.70 |
| Jim Davis* | Aces | 2.72 |
| Turk Lown | Larks | 2.76 |
| Vern Law | Larks | 2.80 |
| Frank Lary | Thunderbolts | 2.90 |
| Bob Lemon | Carp | 2.95 |
| Dick Donovan | Royal Giants | 2.95 |
| Chuck Stobbs* | Larks | 3.07 |
| Billy Pierce* | Larks | 3.13 |
| Connie Johnson | Grays | 3.20 |
| Roger Craig | Carp | 3.34 |
| Virgil Trucks | Thunderbolts | 3.36 |
| Sal Maglie | Thunderbolts | 3.44 |
| Jim Hearn | Grays | 3.46 |
| Bob Buhl | Walleye | 3.48 |
| Warren Spahn* | Walleye | 3.52 |
| Red Munger | Hawks | 3.55 |
| Alex Kellner* | Stampers | 3.56 |
| Curt Simmons* | Larks | 3.61 |
| Jim Wilson | Tigers | 3.62 |
| Herb Score* | Walleye | 3.62 |
| Don Kaiser | Arsenal | 3.63 |
| Herm Wehmeier | Thunderbolts | 3.66 |
| Hal Jeffcoat | Clowns | 3.69 |
| Willard Nixon | Blues | 3.71 |
| Billy Hoeft* | Arsenal | 3.72 |
| Bob Friend | Clowns | 3.74 |
| Carl Erskine | Clowns | 3.77 |
| Hal Brown | Muck Dogs | 3.78 |
| Murry Dickson | Aces | 3.78 |
| Don Larsen | Arsenal | 3.84 |
| Al Worthington | Muck Dogs | 3.88 |
| Saul Rogovin | Royal Giants | 3.94 |
| Whitey Ford* | Arsenal | 3.95 |
| Mike Garcia | Grays | 3.99 |
| Gene Conley | Larks | 4.01 |
| Steve Gromek | Grays | 4.01 |
| Joe Nuxhall* | Grays | 4.04 |
| Lew Burdette | Walleye | 4.07 |
| Robin Roberts | Muck Dogs | 4.09 |
| Frank Sullivan | Tigers | 4.10 |
| Steve Ridzik | Stampers | 4.11 |
| Tom Poholsky | Aces | 4.13 |
| Sam Jones | Aces | 4.22 |
| Ruben Gomez | Hawks | 4.26 |
| Brooks Lawrence | Thunderbolts | 4.27 |
| Vinegar Bend Mizell* | Blues | 4.34 |
| Paul Foytack | Royal Giants | 4.35 |
| Art Fowler | Blues | 4.40 |
| Larry Jackson | Stampers | 4.41 |
| Ray Moore | Aces | 4.43 |
| Johnny Kucks | Blues | 4.44 |
| Dave Sisler | Blues | 4.58 |
| Bill Wight* | Tigers | 4.68 |
| Johnny Antonelli* | Tigers | 4.68 |
| Pedro Ramos | Stampers | 4.79 |
| Ray Crone | Clowns | 4.83 |
| Don Drysdale | Hawks | 4.84 |
| Ike Delock | Larks | 4.86 |
| Tom Gorman | Hawks | 4.89 |
| Camilo Pascual | Tigers | 4.97 |
| Bob Keegan | Clowns | 5.05 |
| Stu Miller | Carp | 5.13 |
| Duke Maas | Royal Giants | 5.16 |
| Harvey Haddix* | Tigers | 5.30 |
| Warren Hacker | Stampers | 5.45 |
| Art Ditmar | Arsenal | 5.57 |
| Johnny Klippstein | Hawks | 5.82 |
| Willard Schmidt | Royal Giants | 5.89 |
| Lou Kretlow | Royal Giants | 5.95 |
| Wally Burnette | Grays | 5.95 |
| Dean Stone* | Arsenal | 6.14 |
| Dick Littlefield* | Hawks | 6.35 |
| Erv Palica | Hawks | 6.38 |
| Ron Kline | Royal Giants | 6.64 |