| Name | Name | ERA |
| Cal McLish | Aces | 1.32 |
| Ned Garver | Larks | 1.75 |
| Billy Pierce* | Larks | 2.06 |
| Don Newcombe | Muck Dogs | 2.20 |
| Don Larsen | Arsenal | 2.21 |
| Stu Miller | Carp | 2.22 |
| Lindy McDaniel | Larks | 2.28 |
| Paul Foytack | Royal Giants | 2.32 |
| Tom Brewer | Carp | 2.37 |
| Lew Burdette | Walleye | 2.54 |
| Bobby Shantz* | Stampers | 2.55 |
| Brooks Lawrence | Thunderbolts | 2.58 |
| Don Drysdale | Hawks | 2.58 |
| Whitey Ford* | Arsenal | 2.58 |
| Jim Bunning | Carp | 2.72 |
| Don Cardwell | Grays | 2.84 |
| Frank Sullivan | Tigers | 2.87 |
| Ralph Terry | Royal Giants | 2.89 |
| Moe Drabowsky | Hawks | 2.92 |
| Bob Rush | Carp | 2.94 |
| Gene Conley | Larks | 2.96 |
| Johnny Kucks | Blues | 2.98 |
| Billy O'Dell* | Grays | 3.00 |
| Curt Simmons* | Larks | 3.03 |
| Bob Purkey | Walleye | 3.06 |
| Bob Friend | Clowns | 3.11 |
| Billy Hoeft* | Arsenal | 3.13 |
| Dick Drott | Blues | 3.15 |
| Sal Maglie | Thunderbolts | 3.18 |
| Mike Fornieles | Carp | 3.18 |
| Art Ditmar | Arsenal | 3.21 |
| Tom Sturdivant | Muck Dogs | 3.23 |
| Jack Sanford | Aces | 3.27 |
| Roger Craig | Carp | 3.30 |
| Early Wynn | Walleye | 3.32 |
| Dick Donovan | Royal Giants | 3.35 |
| Johnny Podres* | Stampers | 3.39 |
| Connie Johnson | Grays | 3.41 |
| Carl Erskine | Clowns | 3.42 |
| Chuck Stobbs* | Larks | 3.51 |
| Don Gross* | Clowns | 3.53 |
| Don Elston | Aces | 3.56 |
| Robin Roberts | Muck Dogs | 3.58 |
| Warren Spahn* | Walleye | 3.59 |
| Frank Lary | Thunderbolts | 3.62 |
| Larry Jackson | Stampers | 3.63 |
| Hal Jeffcoat | Clowns | 3.65 |
| Vern Law | Larks | 3.68 |
| Camilo Pascual | Tigers | 3.76 |
| Bill Wight* | Tigers | 3.77 |
| Duke Maas | Royal Giants | 3.82 |
| Billy Loes | Hawks | 3.84 |
| Mike Garcia | Grays | 3.91 |
| Don Mossi* | Stampers | 3.93 |
| Pedro Ramos | Stampers | 3.94 |
| Johnny Klippstein | Hawks | 3.97 |
| Bob Keegan | | 3.98 |
| Bob Porterfield | Aces | 4.09 |
| Curt Barclay | Blues | 4.11 |
| Bob Turley | Royal Giants | 4.13 |
| Vinegar Bend Mizell* | Blues | 4.26 |
| Johnny Antonelli* | Tigers | 4.26 |
| Sam Jones | Aces | 4.26 |
| Ray Moore | Aces | 4.34 |
| Virgil Trucks | Thunderbolts | 4.37 |
| Bob Buhl | Walleye | 4.48 |
| Herm Wehmeier | Thunderbolts | 4.79 |
| Harvey Haddix* | Tigers | 4.82 |
| Ruben Gomez | Hawks | 5.03 |
| Jim Brosnan | Aces | 5.06 |
| Arnie Portocarrero | Grays | 5.13 |
| Jack Harshman* | Muck Dogs | 5.16 |
| Joe Nuxhall* | Grays | 5.25 |
| Willard Nixon | Blues | 5.45 |
| Dave Hillman | Thunderbolts | 5.66 |
| Hal Brown | Muck Dogs | 5.74 |
| Taylor Phillips* | Arsenal | 5.84 |
| Ron Kline | Royal Giants | 6.01 |
| Jim Wilson | Tigers | 6.16 |
| Sandy Koufax* | Thunderbolts | 6.34 |
| Tom Morgan | Tigers | 6.57 |
| Tom Acker | Clowns | 6.75 |
| Tommy Byrne* | | 7.63 |