| Name | Name | ERA |
| Ned Garver | Larks | 2.17 |
| Cal McLish | Aces | 2.22 |
| Tom Brewer | Carp | 2.31 |
| Stu Miller | Carp | 2.36 |
| Billy Pierce* | Larks | 2.44 |
| Al Worthington | Muck Dogs | 2.48 |
| Don Cardwell | Grays | 2.51 |
| Whitey Ford* | Arsenal | 2.55 |
| Lindy McDaniel | Larks | 2.57 |
| Curt Simmons* | Larks | 2.73 |
| Frank Sullivan | Tigers | 2.78 |
| Don Newcombe | Muck Dogs | 2.79 |
| Bobby Shantz* | Stampers | 2.80 |
| Don Drysdale | Hawks | 2.80 |
| Gene Conley | Larks | 2.82 |
| Bob Friend | Clowns | 2.84 |
| Jim Bunning | Carp | 2.85 |
| Lew Burdette | Walleye | 2.90 |
| Tom Sturdivant | Muck Dogs | 2.90 |
| Don Larsen | Arsenal | 2.95 |
| Billy Hoeft* | Arsenal | 2.95 |
| Brooks Lawrence | Thunderbolts | 3.03 |
| Billy O'Dell* | Grays | 3.04 |
| Johnny Kucks | Blues | 3.12 |
| Dick Donovan | Royal Giants | 3.15 |
| Ralph Terry | Royal Giants | 3.19 |
| Vern Law | Larks | 3.19 |
| Moe Drabowsky | Hawks | 3.20 |
| Billy Loes | Hawks | 3.21 |
| Johnny Podres* | Stampers | 3.23 |
| Sal Maglie | Thunderbolts | 3.26 |
| Connie Johnson | Grays | 3.26 |
| Don Kaiser | Arsenal | 3.28 |
| Bob Rush | Carp | 3.30 |
| Paul Foytack | Royal Giants | 3.34 |
| Carl Erskine | Clowns | 3.42 |
| Bob Keegan | | 3.49 |
| Dave Sisler | Blues | 3.50 |
| Art Ditmar | Arsenal | 3.51 |
| Mike Garcia | Grays | 3.57 |
| Robin Roberts | Muck Dogs | 3.60 |
| Bob Purkey | Walleye | 3.61 |
| Don Elston | Aces | 3.63 |
| Pedro Ramos | Stampers | 3.66 |
| Camilo Pascual | Tigers | 3.71 |
| Ray Crone | Clowns | 3.76 |
| Von McDaniel | | 3.80 |
| Frank Lary | Thunderbolts | 3.81 |
| Early Wynn | Walleye | 3.88 |
| Roger Craig | Carp | 3.91 |
| Johnny Klippstein | Hawks | 3.92 |
| Warren Spahn* | Walleye | 3.96 |
| Bob Turley | Royal Giants | 3.98 |
| Chuck Stobbs* | Larks | 4.07 |
| Dick Drott | Blues | 4.10 |
| Hal Jeffcoat | Clowns | 4.12 |
| Bill Wight* | Tigers | 4.14 |
| Jack Sanford | Aces | 4.19 |
| Don Gross* | Clowns | 4.19 |
| Duke Maas | Royal Giants | 4.22 |
| Larry Jackson | Stampers | 4.23 |
| Vinegar Bend Mizell* | Blues | 4.26 |
| Ray Narleski | Aces | 4.28 |
| Mike Fornieles | Carp | 4.40 |
| Ruben Gomez | Hawks | 4.42 |
| Curt Barclay | Blues | 4.48 |
| Herm Wehmeier | Thunderbolts | 4.64 |
| Virgil Trucks | Thunderbolts | 4.66 |
| Taylor Phillips* | Arsenal | 4.68 |
| Ron Kline | Royal Giants | 4.68 |
| Don Mossi* | Stampers | 4.70 |
| Ray Moore | Aces | 4.72 |
| Bob Buhl | Walleye | 4.73 |
| Harvey Haddix* | Tigers | 4.79 |
| Willard Nixon | Blues | 4.92 |
| Johnny Antonelli* | Tigers | 4.93 |
| Sam Jones | Aces | 5.12 |
| Arnie Portocarrero | Grays | 5.24 |
| Jim Wilson | Tigers | 5.28 |
| Sandy Koufax* | Thunderbolts | 5.43 |
| Joe Nuxhall* | Grays | 5.49 |
| Jack Harshman* | Muck Dogs | 5.72 |
| Hal Brown | Muck Dogs | 5.78 |
| Tom Morgan | Tigers | 6.38 |
| Tommy Byrne* | | 6.92 |