| Name | Name | ERA |
| Al Cicotte | Arsenal | 0.00 |
| Bud Daley* | Thunderbolts | 0.00 |
| Paul Foytack | Royal Giants | 0.41 |
| Larry Jackson | Stampers | 0.50 |
| Sam Jones | Aces | 0.53 |
| Mike Fornieles | Carp | 0.57 |
| Cal McLish | Aces | 0.60 |
| Ralph Terry | Royal Giants | 0.67 |
| Bob Grim | Clowns | 0.93 |
| Roy Face | Carp | 0.96 |
| Dick Farrell | Larks | 1.00 |
| Stu Miller | Carp | 1.00 |
| Billy Pierce* | Larks | 1.04 |
| Frank Baumann* | Stampers | 1.13 |
| Tom Brewer | Carp | 1.29 |
| Billy Hoeft* | Arsenal | 1.44 |
| Jim Bunning | Carp | 1.50 |
| Jack Sanford | Aces | 1.80 |
| Bob Trowbridge | Walleye | 1.86 |
| Don Kaiser | Arsenal | 1.93 |
| Tom Sturdivant | Muck Dogs | 2.05 |
| Warren Spahn* | Walleye | 2.08 |
| Ken Lehman* | Tigers | 2.08 |
| Brooks Lawrence | Thunderbolts | 2.25 |
| Curt Simmons* | Larks | 2.25 |
| Bob Keegan | Clowns | 2.35 |
| Ned Garver | Larks | 2.35 |
| Bob Rush | Carp | 2.49 |
| Don Mossi* | Stampers | 2.50 |
| Lindy McDaniel | Larks | 2.57 |
| Moe Drabowsky | Hawks | 2.61 |
| Dick Donovan | Royal Giants | 2.63 |
| Frank Lary | Thunderbolts | 2.63 |
| Bobby Shantz* | Stampers | 2.63 |
| Chuck Stobbs* | Larks | 2.63 |
| Hersh Freeman | Blues | 2.70 |
| Don Drysdale | Hawks | 2.70 |
| Bob Friend | Clowns | 2.81 |
| Johnny Podres* | Stampers | 2.82 |
| Mike Garcia | Grays | 2.82 |
| Sal Maglie | Thunderbolts | 2.95 |
| Ernie Johnson | Arsenal | 3.00 |
| Don Elston | Aces | 3.00 |
| Taylor Phillips* | Arsenal | 3.14 |
| Dave Hillman | Thunderbolts | 3.27 |
| Johnny Kucks | Blues | 3.38 |
| Frank Sullivan | Tigers | 3.38 |
| Jack Urban | Walleye | 3.38 |
| Bob Buhl | Walleye | 3.44 |
| Ruben Gomez | Hawks | 3.46 |
| Gerry Staley | Blues | 3.52 |
| Duke Maas | Royal Giants | 3.52 |
| Hal Jeffcoat | Clowns | 3.54 |
| Bob Miller | Muck Dogs | 3.55 |
| Don Gross* | Clowns | 3.60 |
| Ray Moore | Aces | 3.60 |
| Don Larsen | Arsenal | 3.65 |
| Joe Nuxhall* | Grays | 3.66 |
| Bob Purkey | Walleye | 3.75 |
| Pedro Ramos | Stampers | 3.75 |
| Roger Craig | Carp | 3.77 |
| Bob Turley | Royal Giants | 3.77 |
| Johnny Antonelli* | Tigers | 3.92 |
| Robin Roberts | Muck Dogs | 3.94 |
| Ralph Lumenti* | Muck Dogs | 3.97 |
| Johnny Klippstein | Hawks | 4.00 |
| Whitey Ford* | Arsenal | 4.02 |
| Bill Wight* | Tigers | 4.05 |
| Harvey Haddix* | Tigers | 4.09 |
| Bob Lemon | Carp | 4.26 |
| Billy Loes | Hawks | 4.41 |
| Camilo Pascual | Tigers | 4.50 |
| Connie Johnson | Grays | 4.70 |
| Sandy Koufax* | Thunderbolts | 4.80 |
| Art Ditmar | Arsenal | 4.80 |
| Lew Burdette | Walleye | 4.87 |
| Ike Delock | Larks | 5.00 |
| Dick Drott | Blues | 5.40 |
| Tommy Byrne* | Clowns | 5.54 |
| Herm Wehmeier | Thunderbolts | 5.63 |
| Arnie Portocarrero | Grays | 5.66 |
| Jim Brosnan | Aces | 5.87 |
| Early Wynn | Walleye | 5.93 |
| Ray Narleski | Aces | 6.00 |
| George Zuverink | Grays | 6.48 |
| Jim Wilson | Tigers | 6.92 |
| Virgil Trucks | Thunderbolts | 7.11 |
| Willard Nixon | Blues | 7.41 |
| Tom Morgan | Tigers | 7.84 |
| Bill Fischer | Grays | 7.88 |
| Dick Tomanek* | Royal Giants | 8.10 |
| Bob Wiesler* | Muck Dogs | 8.16 |
| Ron Kline | Royal Giants | 8.22 |
| Rudy Minarcin | Arsenal | 8.53 |
| Tom Gorman | Hawks | 9.00 |
| Hal Brown | Muck Dogs | 9.72 |
| Bud Byerly | Muck Dogs | 11.00 |
| Vinegar Bend Mizell* | Blues | 11.37 |