| Name | Name | ERA |
| Cal McLish | Aces | 0.40 |
| Al Cicotte | Arsenal | 0.87 |
| Ralph Terry | Royal Giants | 0.96 |
| Don Newcombe | Muck Dogs | 1.35 |
| Tom Brewer | Carp | 1.50 |
| Gene Conley | Larks | 1.61 |
| Stu Miller | Carp | 1.71 |
| Dick Farrell | Larks | 1.71 |
| Curt Simmons* | Larks | 1.78 |
| Lindy McDaniel | Larks | 1.93 |
| Paul Foytack | Royal Giants | 1.95 |
| Bob Rush | Carp | 2.09 |
| Jack Urban | Walleye | 2.16 |
| Billy Pierce* | Larks | 2.16 |
| Jim Bunning | Carp | 2.16 |
| Don Mossi* | Stampers | 2.20 |
| Don Larsen | Arsenal | 2.28 |
| Brooks Lawrence | Thunderbolts | 2.31 |
| Johnny Kucks | Blues | 2.35 |
| Ernie Johnson | Arsenal | 2.37 |
| Don Drysdale | Hawks | 2.40 |
| Lou Sleater* | Clowns | 2.41 |
| Clem Labine | Muck Dogs | 2.41 |
| Don Cardwell | Grays | 2.42 |
| Johnny Klippstein | Hawks | 2.61 |
| Connie Johnson | Grays | 2.64 |
| Bob Friend | Clowns | 2.65 |
| Frank Sullivan | Tigers | 2.74 |
| Sal Maglie | Thunderbolts | 2.76 |
| Larry Jackson | Stampers | 2.77 |
| Billy Hoeft* | Arsenal | 2.78 |
| Tom Sturdivant | Muck Dogs | 2.83 |
| Mike Fornieles | Carp | 2.84 |
| Lew Burdette | Walleye | 2.84 |
| Vern Law | Larks | 2.88 |
| Duke Maas | Royal Giants | 2.96 |
| Johnny Podres* | Stampers | 2.98 |
| Dick Donovan | Royal Giants | 3.00 |
| Roy Face | Carp | 3.00 |
| Robin Roberts | Muck Dogs | 3.00 |
| Camilo Pascual | Tigers | 3.06 |
| Frank Lary | Thunderbolts | 3.06 |
| Whitey Ford* | Arsenal | 3.11 |
| Wally Burnette | Grays | 3.12 |
| Bob Purkey | Walleye | 3.12 |
| Ned Garver | Larks | 3.16 |
| Carl Erskine | Clowns | 3.19 |
| Bobby Shantz* | Stampers | 3.26 |
| Moe Drabowsky | Hawks | 3.28 |
| Sam Jones | Aces | 3.29 |
| Don Elston | Aces | 3.35 |
| Early Wynn | Walleye | 3.45 |
| Roger Craig | Carp | 3.53 |
| Ruben Gomez | Hawks | 3.54 |
| Don Kaiser | Arsenal | 3.58 |
| Chuck Stobbs* | Larks | 3.62 |
| Mike Garcia | Grays | 3.65 |
| Warren Spahn* | Walleye | 3.67 |
| Tex Clevenger | Carp | 3.74 |
| Pedro Ramos | Stampers | 3.89 |
| Don Gross* | Clowns | 3.93 |
| Taylor Phillips* | Arsenal | 3.97 |
| Hersh Freeman | Blues | 4.01 |
| Vinegar Bend Mizell* | Blues | 4.06 |
| Bob Miller | Muck Dogs | 4.08 |
| Bob Turley | Royal Giants | 4.15 |
| Bob Buhl | Walleye | 4.17 |
| Ed Roebuck | Hawks | 4.19 |
| Harvey Haddix* | Tigers | 4.38 |
| Johnny Antonelli* | Tigers | 4.53 |
| Jack Sanford | Aces | 4.57 |
| Ray Narleski | Aces | 4.63 |
| Bill Wight* | Tigers | 4.67 |
| Hal Jeffcoat | Clowns | 4.73 |
| Joe Nuxhall* | Grays | 4.82 |
| Art Ditmar | Arsenal | 4.82 |
| Virgil Trucks | Thunderbolts | 4.91 |
| Jim Brosnan | Aces | 5.00 |
| Ray Moore | Aces | 5.05 |
| Whammy Douglas | Tigers | 5.09 |
| Dick Drott | Blues | 5.13 |
| Herm Wehmeier | Thunderbolts | 5.19 |
| Billy Loes | Hawks | 5.20 |
| Jim Wilson | Tigers | 5.57 |
| Arnie Portocarrero | Grays | 5.63 |
| Bob Keegan | Clowns | 5.77 |
| Bob Lemon | Carp | 5.87 |
| Dave Hillman | Thunderbolts | 5.93 |
| Billy O'Dell* | Grays | 6.27 |
| Dean Stone* | Arsenal | 6.30 |
| Ted Abernathy | Larks | 6.48 |
| Hal Brown | Muck Dogs | 6.48 |
| Jack Harshman* | Muck Dogs | 6.75 |
| Curt Barclay | Blues | 6.84 |
| Bud Byerly | Muck Dogs | 6.87 |
| Sandy Koufax* | Thunderbolts | 7.23 |
| Tom Morgan | Tigers | 7.24 |
| Ray Crone | Clowns | 7.36 |
| Art Fowler | Blues | 7.41 |
| Ron Kline | Royal Giants | 8.67 |
| Willard Nixon | Blues | 11.14 |