| Name | Name | ERA |
| Stu Miller | Carp | 1.09 |
| Cal McLish | Aces | 1.39 |
| Curt Simmons* | Larks | 1.58 |
| Jack Urban | Walleye | 1.59 |
| Don Newcombe | Muck Dogs | 1.66 |
| Lindy McDaniel | Larks | 1.90 |
| Paul Foytack | Royal Giants | 2.00 |
| Don Cardwell | Grays | 2.15 |
| Don Drysdale | Hawks | 2.16 |
| Frank Sullivan | Tigers | 2.22 |
| Don Larsen | Arsenal | 2.30 |
| Connie Johnson | Grays | 2.33 |
| Bob Porterfield | Aces | 2.41 |
| Billy Pierce* | Larks | 2.42 |
| Tom Brewer | Carp | 2.44 |
| Gene Conley | Larks | 2.45 |
| Bob Rush | Carp | 2.54 |
| Ralph Terry | Royal Giants | 2.60 |
| Lew Burdette | Walleye | 2.61 |
| Johnny Podres* | Stampers | 2.64 |
| Tex Clevenger | Carp | 2.64 |
| Brooks Lawrence | Thunderbolts | 2.66 |
| Dick Farrell | Larks | 2.67 |
| Sal Maglie | Thunderbolts | 2.72 |
| Mike Fornieles | Carp | 2.74 |
| Ned Garver | Larks | 2.76 |
| Bob Friend | Clowns | 2.76 |
| Tom Sturdivant | Muck Dogs | 2.77 |
| Bud Daley* | Thunderbolts | 2.77 |
| Bob Purkey | Walleye | 2.80 |
| Jim Bunning | Carp | 2.80 |
| Bobby Shantz* | Stampers | 2.89 |
| Robin Roberts | Muck Dogs | 2.91 |
| Johnny Kucks | Blues | 2.97 |
| Whitey Ford* | Arsenal | 3.02 |
| Von McDaniel |   | 3.06 |
| Jack Sanford | Aces | 3.07 |
| Wally Burnette | Grays | 3.10 |
| Turk Lown | Larks | 3.18 |
| Dick Donovan | Royal Giants | 3.19 |
| Moe Drabowsky | Hawks | 3.24 |
| Hersh Freeman | Blues | 3.24 |
| Don Gross* | Clowns | 3.24 |
| Larry Jackson | Stampers | 3.25 |
| Duke Maas | Royal Giants | 3.31 |
| Don Mossi* | Stampers | 3.34 |
| Dick Drott | Blues | 3.42 |
| Early Wynn | Walleye | 3.44 |
| Billy Hoeft* | Arsenal | 3.44 |
| Warren Spahn* | Walleye | 3.46 |
| Hal Jeffcoat | Clowns | 3.50 |
| Vern Law | Larks | 3.50 |
| Camilo Pascual | Tigers | 3.52 |
| Don Kaiser | Arsenal | 3.52 |
| Bob Turley | Royal Giants | 3.72 |
| Billy O'Dell* | Grays | 3.72 |
| Sam Jones | Aces | 3.74 |
| Bill Wight* | Tigers | 3.75 |
| Frank Lary | Thunderbolts | 3.82 |
| Don Elston | Aces | 3.83 |
| Bob Buhl | Walleye | 3.95 |
| Billy Loes | Hawks | 3.99 |
| Roger Craig | Carp | 4.08 |
| Carl Erskine | Clowns | 4.10 |
| Chuck Stobbs* | Larks | 4.14 |
| Mike Garcia | Grays | 4.16 |
| Harvey Haddix* | Tigers | 4.17 |
| Art Ditmar | Arsenal | 4.18 |
| Johnny Klippstein | Hawks | 4.19 |
| Bob Keegan |   | 4.26 |
| Ruben Gomez | Hawks | 4.40 |
| Johnny Antonelli* | Tigers | 4.48 |
| Virgil Trucks | Thunderbolts | 4.57 |
| Ray Moore | Aces | 4.70 |
| Jim Brosnan | Aces | 4.74 |
| Bud Byerly | Muck Dogs | 4.75 |
| Vinegar Bend Mizell* | Blues | 4.77 |
| Taylor Phillips* | Arsenal | 4.81 |
| Herm Wehmeier | Thunderbolts | 4.91 |
| Pedro Ramos | Stampers | 5.00 |
| Arnie Portocarrero | Grays | 5.01 |
| Curt Barclay | Blues | 5.10 |
| Ray Narleski | Aces | 5.14 |
| Roy Face | Carp | 5.46 |
| Joe Nuxhall* | Grays | 5.50 |
| Hal Brown | Muck Dogs | 5.66 |
| Dave Hillman | Thunderbolts | 6.00 |
| Bob Lemon | Carp | 6.03 |
| Jim Wilson | Tigers | 6.05 |
| Jack Harshman* | Muck Dogs | 6.11 |
| Willard Nixon | Blues | 6.27 |
| Tom Morgan | Tigers | 6.75 |
| Ron Kline | Royal Giants | 6.91 |
| Sandy Koufax* | Thunderbolts | 8.16 |
| Tommy Byrne* | Clowns | 9.47 |