| Name | Name | ERA |
| J.R. Richard | Snow Bears | 1.80 |
| Mario Soto | Storm | 1.97 |
| Tommy Boggs | Comets | 1.99 |
| Don Sutton | Lightning | 2.00 |
| Steve Renko | Storm | 2.28 |
| Dave Stieb | Snow Bears | 2.42 |
| Phil Niekro | Comets | 2.42 |
| Jerry Reuss* | Serranos | 2.42 |
| Rick Waits* | Barons | 2.45 |
| Mike Norris | Oaks | 2.46 |
| Ferguson Jenkins | Mud Hens | 2.49 |
| David Palmer | Oaks | 2.53 |
| Tom Underwood* | Serranos | 2.60 |
| Jim Bibby | Revenge | 2.70 |
| Steve Carlton* | Hired Guns | 2.75 |
| Freddie Martinez | Magpies | 2.85 |
| Gaylord Perry | Barons | 2.88 |
| Steve Rogers | Ghosts | 2.91 |
| Renie Martin | Comets | 2.91 |
| Rick Reuschel | Grays | 2.95 |
| John Candelaria* | Zoo Crew | 2.95 |
| Jon Matlack* | Firebugs | 2.96 |
| Rudy May* | Revolvers | 2.97 |
| Frank Pastore | Plainsmen | 2.99 |
| Joe Niekro | Comets | 3.00 |
| Ross Baumgarten* | Snow Bears | 3.03 |
| Moose Haas | Rovers | 3.04 |
| Dan Schatzeder* | Hired Guns | 3.06 |
| Steve Stone | Firebugs | 3.16 |
| Britt Burns* | Firebugs | 3.19 |
| Glenn Abbott | Volcanoes | 3.20 |
| Eddie Whitson | Gnomes | 3.20 |
| Rick Langford | Oaks | 3.20 |
| Jerry Koosman* | Storm | 3.23 |
| Bert Blyleven | Magpies | 3.26 |
| Vida Blue* | Lightning | 3.30 |
| Mike Proly | Nukes | 3.30 |
| Allen Ripley | Zoo Crew | 3.32 |
| Matt Keough | Canaries | 3.34 |
| Dan Petry | 5-0's | 3.34 |
| Dennis Eckersley | Lemmings | 3.36 |
| Jim Clancy | Oaks | 3.37 |
| Ken Forsch | Volcanoes | 3.38 |
| Scott McGregor* | Ghosts | 3.39 |
| Len Barker | Mud Hens | 3.45 |
| Fernando Arroyo | Rovers | 3.45 |
| Tom Seaver | Lightning | 3.47 |
| Rick Honeycutt* | Canaries | 3.49 |
| Dennis Leonard | Grays | 3.50 |
| John Curtis* | Firebugs | 3.50 |
| Bob Welch | Comets | 3.50 |
| Pete Falcone* | Mud Hens | 3.52 |
| Jim Palmer | Lightning | 3.55 |
| Steve Mura | Snow Bears | 3.55 |
| Pete Vuckovich | Snow Bears | 3.58 |
| Brian Kingman | Rovers | 3.59 |
| Paul Splittorff* | Gnomes | 3.60 |
| Floyd Bannister* | Plainsmen | 3.60 |
| Ron Guidry* | Lightning | 3.62 |
| Jim Beattie | Canaries | 3.68 |
| Rich Gale | Revenge | 3.68 |
| Burt Hooton | Hired Guns | 3.69 |
| Reggie Cleveland | Revolvers | 3.70 |
| Craig Swan | Storm | 3.71 |
| Bill Gullickson | Lemmings | 3.72 |
| Mike Torrez | Serranos | 3.74 |
| Tommy John* | Snow Bears | 3.74 |
| Steve Trout* | 5-0's | 3.76 |
| Randy Jones* | Revolvers | 3.78 |
| Nolan Ryan | Revolvers | 3.81 |
| Bill Travers* | Canaries | 3.82 |
| Vern Ruhle | Plainsmen | 3.86 |
| Bob Stanley | Barons | 3.87 |
| Pat Zachry | Canaries | 3.88 |
| Mike Flanagan* | Gnomes | 3.91 |
| Pete Redfern | Nukes | 3.92 |
| Luis Tiant | Volcanoes | 3.92 |
| Paul Moskau | Lemmings | 3.96 |
| Milt Wilcox | Storm | 4.01 |
| Mike Krukow | Zoo Crew | 4.01 |
| Dick Ruthven | Revenge | 4.02 |
| Larry Gura* | Revolvers | 4.03 |
| Jim Kaat* | Rovers | 4.06 |
| Dave Frost | 5-0's | 4.08 |
| Richard Dotson | Magpies | 4.09 |
| Rick Matula | Plainsmen | 4.12 |
| Bob Knepper* | Ghosts | 4.13 |
| Geoff Zahn* | Volcanoes | 4.13 |
| Charlie Leibrandt* | Zoo Crew | 4.15 |
| Mike LaCoss | Mud Hens | 4.17 |
| Dave Rozema | Canaries | 4.21 |
| Lary Sorensen | Firebugs | 4.33 |
| Bob Forsch | Lemmings | 4.40 |
| Lynn McGlothen | Gnomes | 4.41 |
| Mike Caldwell* | Barons | 4.43 |
| Scott Sanderson | Revenge | 4.45 |
| Jack Morris | Grays | 4.52 |
| Rick Rhoden | Storm | 4.52 |
| Doyle Alexander | Grays | 4.60 |
| Ray Burris | Nukes | 4.61 |
| Doc Medich | Oaks | 4.65 |
| Rick Wise | Zoo Crew | 4.74 |
| Darrell Jackson* | Ghosts | 4.84 |
| Don Aase | Magpies | 4.85 |
| Mike Parrott | Rovers | 4.87 |
| Steve McCatty | Plainsmen | 4.88 |
| Larry McWilliams* | Mud Hens | 4.94 |
| Roger Erickson | Barons | 5.03 |
| Randy Lerch* | 5-0's | 5.04 |
| Frank Tanana* | Lemmings | 5.14 |
| Paul Mirabella* | Hired Guns | 5.25 |
| Ken Kravec* | Nukes | 5.33 |
| Dennis Lamp | 5-0's | 5.69 |
| Bob Walk | Serranos | 5.84 |
| Ross Grimsley* | Rovers | 5.92 |
| Rich Wortham* | Nukes | 5.94 |
| Rick Sutcliffe | Serranos | 6.10 |