| Name | Name | ERA |
| Jim Kaat* | Lightning | 2.40 |
| Glen Hobbie | Lakers | 2.48 |
| Sandy Koufax* | Tarheels | 2.75 |
| Billy Hoeft* | Mets | 2.89 |
| Don Cardwell | Mets | 2.93 |
| Ted Bowsfield* | Frigates | 3.01 |
| Juan Pizarro* | Lakers | 3.02 |
| Norm Bass | Ahabs | 3.03 |
| Dick Hall | Ahabs | 3.10 |
| Jim Bunning | Frigates | 3.15 |
| Mike McCormick* | Robbers | 3.15 |
| Harvey Haddix* | Bears | 3.17 |
| Dick Donovan | Mets | 3.19 |
| Frank Lary | Tigers | 3.19 |
| Billy O'Dell* | Rockets | 3.25 |
| Jim Archer* | Frigates | 3.26 |
| Art Mahaffey | Tigers | 3.30 |
| Hoyt Wilhelm | Rockets | 3.32 |
| Don Mossi* | Tigers | 3.39 |
| Jim O'Toole* | Saints | 3.39 |
| Johnny Podres* | Mets | 3.44 |
| Don Drysdale | Lightning | 3.47 |
| Stan Williams | Lightning | 3.58 |
| Camilo Pascual | Ahabs | 3.70 |
| Juan Marichal | Tarheels | 3.70 |
| Tracy Stallard | Tigers | 3.74 |
| Bob Gibson | Lightning | 3.75 |
| Cal McLish | Ahabs | 3.77 |
| Barry Latman | Rockets | 3.83 |
| Bill Stafford | Jakes | 3.85 |
| Ken McBride | Rockets | 3.87 |
| Lew Burdette | Mets | 3.89 |
| Ray Sadecki* | Bears | 3.89 |
| Warren Spahn* | Lakers | 3.91 |
| Curt Simmons* | Black Cats | 3.95 |
| Ed Hobaugh | Rockets | 3.95 |
| Joe Gibbon* | Robbers | 3.99 |
| Jim Maloney | Tarheels | 4.00 |
| Milt Pappas | Saints | 4.01 |
| Hal Brown | Bears | 4.06 |
| Bennie Daniels | Rockets | 4.07 |
| Steve Barber* | Saints | 4.09 |
| Jack Sanford | Lakers | 4.11 |
| Bob Purkey | Frigates | 4.17 |
| Rollie Sheldon | Lightning | 4.17 |
| Bill Monbouquette | Bears | 4.22 |
| Jack Curtis* | Tarheels | 4.22 |
| Bob Buhl | Tigers | 4.29 |
| Pete Burnside* | Frigates | 4.30 |
| Ed Rakow | Lightning | 4.31 |
| Jack Kralick* | Black Cats | 4.33 |
| Don Schwall | Jakes | 4.36 |
| John Buzhardt | Jakes | 4.36 |
| Dick Ellsworth* | Argonauts | 4.39 |
| Mudcat Grant | Lakers | 4.44 |
| Bob Friend | Black Cats | 4.45 |
| Early Wynn | Rockets | 4.46 |
| Larry Jackson | Lakers | 4.56 |
| Pedro Ramos | Black Cats | 4.56 |
| Billy Loes | Saints | 4.58 |
| Whitey Ford* | Mets | 4.58 |
| Chuck Estrada | Jakes | 4.66 |
| Bob Anderson | Robbers | 4.70 |
| Gary Bell | Ahabs | 4.76 |
| Tom Sturdivant | Argonauts | 4.77 |
| Ernie Broglio | Saints | 4.79 |
| Ray Herbert | Ahabs | 4.84 |
| Ralph Terry | Robbers | 4.85 |
| Joey Jay | Mets | 4.90 |
| Ken Hunt | Tarheels | 4.90 |
| Jack Fisher | Argonauts | 4.91 |
| Roger Craig | Black Cats | 4.96 |
| Joe Nuxhall* | Lakers | 4.96 |
| Paul Foytack | Bears | 5.00 |
| Billy Pierce* | Frigates | 5.04 |
| Jim Coates | Ahabs | 5.05 |
| Ron Moeller* | Tarheels | 5.23 |
| Gene Conley | Argonauts | 5.25 |
| Bob Hendley* | Saints | 5.30 |
| Wynn Hawkins | Saints | 5.34 |
| Robin Roberts | Bears | 5.56 |
| Jerry Walker | Argonauts | 5.58 |
| Eli Grba | Jakes | 5.59 |
| Sam Jones | Black Cats | 5.62 |
| Bob Shaw | Robbers | 5.62 |
| Ryne Duren | Lakers | 5.69 |
| Carl Willey | Robbers | 5.84 |
| Joe McClain | Jakes | 5.85 |
| Mike Fornieles | Rockets | 6.07 |
| Chris Short* | Tarheels | 6.38 |
| Jim Perry | Argonauts | 6.63 |
| Frank Baumann* | Lakers | 6.83 |
| Bud Daley* | Jakes | 7.17 |