| Name | Name | K |
| Sandy Koufax* | Tarheels | 186 |
| Joe Gibbon* | Robbers | 132 |
| Stan Williams | Lightning | 131 |
| Jim O'Toole* | Saints | 115 |
| Mike McCormick* | Robbers | 114 |
| Bob Gibson | Lightning | 110 |
| Art Mahaffey | Tigers | 110 |
| Camilo Pascual | Ahabs | 108 |
| Jim Kaat* | Lightning | 105 |
| Ken McBride | Rockets | 93 |
| Juan Pizarro* | Lakers | 90 |
| Don Cardwell | Mets | 89 |
| Don Drysdale | Lightning | 89 |
| Chuck Estrada | Jakes | 89 |
| Bill Monbouquette | Bears | 88 |
| Gary Bell | Ahabs | 87 |
| Don Mossi* | Tigers | 83 |
| Jim Archer* | Frigates | 81 |
| Joey Jay | Mets | 81 |
| Barry Latman | Rockets | 81 |
| Frank Lary | Tigers | 80 |
| Pedro Ramos | Black Cats | 80 |
| Billy O'Dell* | Rockets | 78 |
| Juan Marichal | Tarheels | 74 |
| Jim Bunning | Frigates | 72 |
| Bob Friend | Black Cats | 72 |
| Harvey Haddix* | Bears | 71 |
| Ernie Broglio | Saints | 70 |
| Jack Kralick* | Black Cats | 67 |
| Steve Barber* | Saints | 66 |
| Whitey Ford* | Mets | 65 |
| Ray Sadecki* | Bears | 65 |
| Ken Hunt | Tarheels | 64 |
| Jim Maloney | Tarheels | 64 |
| Jack Fisher | Argonauts | 63 |
| Billy Pierce* | Frigates | 63 |
| Warren Spahn* | Lakers | 61 |
| Ralph Terry | Robbers | 59 |
| Ryne Duren | Lakers | 59 |
| Milt Pappas | Saints | 58 |
| Tracy Stallard | Tigers | 58 |
| Bob Purkey | Frigates | 57 |
| Bill Stafford | Jakes | 57 |
| Bennie Daniels | Rockets | 56 |
| Early Wynn | Rockets | 56 |
| Glen Hobbie | Lakers | 55 |
| Cal McLish | Ahabs | 55 |
| Carl Willey | Robbers | 55 |
| Paul Foytack | Bears | 52 |
| Jack Sanford | Lakers | 52 |
| Dick Donovan | Mets | 51 |
| Joe Nuxhall* | Lakers | 51 |
| Gene Conley | Argonauts | 50 |
| Ed Hobaugh | Rockets | 50 |
| Sam Jones | Black Cats | 49 |
| Tom Sturdivant | Argonauts | 49 |
| Mudcat Grant | Lakers | 48 |
| Ted Bowsfield* | Frigates | 47 |
| Dick Ellsworth* | Argonauts | 45 |
| Curt Simmons* | Black Cats | 45 |
| Don Schwall | Jakes | 44 |
| Ray Herbert | Ahabs | 44 |
| Frank Baumann* | Lakers | 43 |
| Roger Craig | Black Cats | 43 |
| Arnold Earley* | Ahabs | 43 |
| Art Fowler | Jakes | 42 |
| Dick Hall | Ahabs | 42 |
| Bobby Shantz* | Ahabs | 42 |
| Billy Hoeft* | Mets | 41 |
| Larry Jackson | Lakers | 41 |
| Hoyt Wilhelm | Rockets | 41 |
| Rollie Sheldon | Lightning | 40 |
| Luis Arroyo* | Jakes | 39 |
| Bob Buhl | Tigers | 39 |
| Jim Coates | Ahabs | 39 |
| Jack Curtis* | Tarheels | 39 |
| Dave Hillman | Saints | 39 |
| Stu Miller | Tigers | 39 |
| Jim Perry | Argonauts | 39 |
| Johnny Podres* | Mets | 39 |
| Ed Rakow | Lightning | 39 |
| Lew Burdette | Mets | 38 |
| Barney Schultz | Mets | 38 |
| Don Lee | Lightning | 37 |
| Al McBean | Tarheels | 36 |
| Hal Brown | Bears | 35 |
| John Buzhardt | Jakes | 35 |
| Frank Funk | Jakes | 35 |
| Eli Grba | Jakes | 35 |
| Marty Kutyna | Rockets | 35 |
| Clem Labine | Argonauts | 35 |
| Turk Farrell | Mets | 34 |
| Bob Shaw | Robbers | 34 |
| Bob Hendley* | Saints | 33 |
| Frank Sullivan | Robbers | 33 |
| Pete Burnside* | Frigates | 32 |
| Bill Henry* | Tigers | 31 |
| Robin Roberts | Bears | 31 |
| Chris Short* | Tarheels | 31 |
| Don Elston | Frigates | 30 |
| Mike Fornieles | Rockets | 30 |
| Billy Loes | Saints | 30 |
| Don Nottebart | Black Cats | 30 |
| Jim Donohue | Robbers | 30 |
| Jack Baldschun | Rockets | 29 |
| Al Cicotte | Bears | 28 |
| Tony Cloninger | Argonauts | 28 |
| Turk Lown | Tigers | 28 |
| Joe McClain | Jakes | 27 |
| Bobby Bolin | Saints | 26 |
| Ron Perranoski* | Frigates | 26 |
| Jerry Walker | Argonauts | 26 |
| Roy Face | Black Cats | 25 |
| Wynn Hawkins | Saints | 25 |
| Jay Hook | Tarheels | 25 |
| Bud Daley* | Jakes | 25 |
| Bob Anderson | Robbers | 24 |
| Vinegar Bend Mizell* | Saints | 24 |
| Tom Morgan | Jakes | 24 |
| Larry Sherry | Lightning | 24 |
| Dave Sisler | Frigates | 24 |
| Jim Duffalo | Tarheels | 23 |
| Johnny Klippstein | Argonauts | 23 |
| Wes Stock | Robbers | 23 |
| Tom Cheney | Tarheels | 23 |
| Sherman Jones | Black Cats | 22 |
| Jerry Casale | Argonauts | 21 |
| Johnny James | Saints | 21 |
| Ike Delock | Argonauts | 20 |
| Bob Miller | Ahabs | 20 |
| Jim Brosnan | Jakes | 19 |
| Ray Moore | Bears | 19 |
| Chet Nichols* | Tigers | 19 |
| Phil Regan | Argonauts | 19 |
| Dick Stigman* | Robbers | 19 |
| Art Ditmar | Black Cats | 19 |
| Gerry Staley | Argonauts | 19 |
| Dick Drott | Rockets | 18 |
| Earl Francis | Ahabs | 18 |
| Jack Spring* | Frigates | 17 |
| Ron Kline | Mets | 17 |
| Norm Bass | Ahabs | 16 |
| John Gabler | Robbers | 16 |
| Hal Reniff | Lightning | 16 |
| Don Larsen | Jakes | 16 |
| Craig Anderson | Black Cats | 15 |
| Dallas Green | Lakers | 15 |
| Lew Krausse | Lightning | 15 |
| Hal Woodeshick* | Lakers | 15 |
| Terry Fox | Bears | 14 |
| Warren Hacker | Frigates | 14 |
| Bobby Locke | Saints | 13 |
| Don McMahon | Bears | 13 |
| Tom Brewer | Ahabs | 12 |
| Don Ferrarese* | Lightning | 12 |
| Marshall Bridges* | Bears | 11 |
| Lindy McDaniel | Lightning | 11 |
| Claude Raymond | Frigates | 11 |
| John Wyatt | Tarheels | 11 |
| Hank Aguirre* | Bears | 10 |
| Bob Allen* | Robbers | 10 |
| Ron Moeller* | Tarheels | 10 |
| Howie Nunn | Bears | 10 |
| Bill Fischer | Tarheels | 10 |
| Bob Bruce | Lakers | 9 |
| Vern Law | Tigers | 9 |
| Jim Owens | Rockets | 9 |
| Bob Turley | Argonauts | 9 |
| Ken Johnson | Mets | 8 |
| Eddie Fisher | Lakers | 7 |
| Jim Brewer* | Mets | 6 |
| Russ Kemmerer | Lightning | 6 |
| Al Jackson* | Lakers | 5 |
| Bill Dailey | Saints | 4 |
| Ned Garver | Bears | 4 |
| Bill Kunkel | Tarheels | 4 |
| Gary Peters* | Tarheels | 4 |
| Bill Pleis* | Robbers | 4 |
| Dave Wickersham | Tigers | 4 |
| Dick LeMay* | Mets | 3 |
| Ron Piche | Frigates | 3 |
| Gerry Arrigo* | Tigers | 2 |
| Ray Washburn | Tigers | 2 |
| George Brunet* | Tarheels | 1 |
| Jim Golden | Black Cats | 1 |
| Ken Lehman* | Lightning | 1 |
| Al Schroll | Bears | 1 |
| Danny McDevitt* | Saints | 1 |
| Galen Cisco | Tigers | 0 |
| Moe Drabowsky | Lakers | 0 |
| Chi-chi Olivo | Argonauts | 0 |
| Joe Schaffernoth | Rockets | 0 |