| Name | Name | ERA |
| Dick Ellsworth* | Argonauts | 1.98 |
| Gary Peters* | Tarheels | 2.03 |
| Juan Marichal | Tarheels | 2.03 |
| Al Downing* | Colt 45's | 2.13 |
| Sandy Koufax* | Tarheels | 2.13 |
| Turk Farrell | Colt 45's | 2.15 |
| Bob Gibson | Lightning | 2.35 |
| Dick Radatz | Ahabs | 2.36 |
| Camilo Pascual | Ahabs | 2.45 |
| Tom Cheney | Tarheels | 2.48 |
| Don Drysdale | Lightning | 2.48 |
| Cal McLish | Bullies | 2.56 |
| Hoyt Wilhelm | Lightning | 2.61 |
| Ed Rakow | Grays | 2.62 |
| Juan Pizarro* | Colt 45's | 2.66 |
| Steve Barber* | Saints | 2.79 |
| John Tsitouris | Grays | 2.82 |
| Bob Friend | Black Cats | 2.85 |
| Ernie Broglio | Saints | 2.87 |
| Dick Stigman* | Bombers | 2.89 |
| Gary Bell | Ahabs | 2.90 |
| Ray Herbert | Ahabs | 2.92 |
| Roger Craig | Colt 45's | 3.04 |
| Lew Burdette | Mets | 3.06 |
| Bob Bruce | Colt 45's | 3.08 |
| Ken McBride | Frigates | 3.10 |
| Bob Sadowski | Tigers | 3.11 |
| Dave Wickersham | Rockets | 3.17 |
| Ray Culp | Black Cats | 3.20 |
| Jack Sanford | Tigers | 3.21 |
| Al McBean | Tarheels | 3.23 |
| Curt Simmons* | Black Cats | 3.25 |
| Don Cardwell | Mets | 3.27 |
| Ralph Terry | Bombers | 3.28 |
| Dave Morehead | Bullies | 3.31 |
| Jim Maloney | Tarheels | 3.32 |
| Mudcat Grant | Colt 45's | 3.38 |
| Ken Johnson | Mets | 3.41 |
| Billy O'Dell* | Rockets | 3.42 |
| Mickey Lolich* | Argonauts | 3.43 |
| Bob Buhl | Tigers | 3.46 |
| Bob Hendley* | Saints | 3.48 |
| Orlando Pena | Mets | 3.48 |
| John Buzhardt | Jakes | 3.49 |
| Hal Brown | | 3.52 |
| Moe Drabowsky | Colt 45's | 3.53 |
| Ron Perranoski* | Frigates | 3.54 |
| Dennis Bennett* | Lightning | 3.55 |
| Don Nottebart | Grays | 3.57 |
| Chris Short* | Rockets | 3.60 |
| Johnny Podres* | Mets | 3.60 |
| Larry Jackson | Black Cats | 3.60 |
| Jim O'Toole* | Saints | 3.61 |
| Robin Roberts | Bears | 3.63 |
| Whitey Ford* | Mets | 3.73 |
| Bennie Daniels | Rockets | 3.74 |
| Don Rudolph* | Rockets | 3.85 |
| Bill Monbouquette | Bears | 3.87 |
| Al Jackson* | Tigers | 3.87 |
| Jim Bouton | Saints | 3.89 |
| Bob Heffner | Bears | 3.90 |
| Diego Segui | Ahabs | 3.91 |
| Art Mahaffey | Tigers | 3.94 |
| Don Schwall | Jakes | 3.97 |
| Carl Willey | Jakes | 3.97 |
| Bob Miller | Ahabs | 3.99 |
| Joe Nuxhall* | Bullies | 3.99 |
| Warren Spahn* | Frigates | 4.02 |
| Earl Wilson | Lightning | 4.03 |
| Jim Kaat* | Lightning | 4.11 |
| Jim Bunning | Frigates | 4.13 |
| Jim Perry | Argonauts | 4.13 |
| Lee Stange | Lightning | 4.18 |
| Stan Williams | Bullies | 4.19 |
| Dan Osinski | Tigers | 4.28 |
| Bob Turley | Bullies | 4.31 |
| Bob Shaw | Bombers | 4.34 |
| Bill Faul | Jakes | 4.35 |
| Tom Sturdivant | Argonauts | 4.36 |
| Tony Cloninger | | 4.40 |
| Galen Cisco | Grays | 4.55 |
| Dean Chance | Bombers | 4.55 |
| Eddie Fisher | Mets | 4.59 |
| Denny Lemaster* | Rockets | 4.63 |
| Pedro Ramos | Frigates | 4.74 |
| Claude Osteen* | Bombers | 4.76 |
| Tracy Stallard | Grays | 4.79 |
| Frank Lary | Grays | 4.85 |
| Phil Regan | | 4.89 |
| Hank Aguirre* | Bears | 4.91 |
| Barry Latman | Rockets | 4.95 |
| Dallas Green | Argonauts | 4.96 |
| Don Lee | | 5.08 |
| Dick Donovan | Jakes | 5.16 |
| Milt Pappas | Saints | 5.19 |
| Joe Horlen | Jakes | 5.20 |
| Jack Fisher | Argonauts | 5.40 |
| Jack Kralick* | | 5.42 |
| Jerry Walker | Bullies | 5.44 |
| Joey Jay | Grays | 5.60 |
| Ray Sadecki* | Bears | 5.64 |
| Bob Purkey | Frigates | 5.77 |
| Mike McCormick* | Bombers | 6.20 |
| Dick Drott | Rockets | 6.65 |
| Glen Hobbie | Grays | 6.90 |
| Jim Duckworth | Jakes | 7.44 |
| Bill Stafford | Jakes | 8.92 |