| Name | Name | K |
| Sandy Koufax* | Tarheels | 293 |
| Jim Maloney | Tarheels | 251 |
| Camilo Pascual | Ahabs | 201 |
| Gary Peters* | Tarheels | 200 |
| Dick Stigman* | Bombers | 196 |
| Don Drysdale | Lightning | 195 |
| Jim Bunning | Frigates | 187 |
| Bob Gibson | Lightning | 184 |
| Juan Marichal | Tarheels | 184 |
| Joe Nuxhall* | Bullies | 163 |
| Dick Ellsworth* | Argonauts | 160 |
| Pedro Ramos | Frigates | 159 |
| Steve Barber* | Saints | 154 |
| Whitey Ford* | Mets | 153 |
| Jack Sanford | Tigers | 147 |
| Dave Morehead | Bullies | 144 |
| Dean Chance | Bombers | 142 |
| Al Downing* | Colt 45's | 142 |
| Bill Monbouquette | Bears | 142 |
| Chris Short* | Rockets | 142 |
| Turk Farrell | Colt 45's | 137 |
| Al Jackson* | Tigers | 135 |
| Denny Lemaster* | Rockets | 135 |
| Ken McBride | Frigates | 135 |
| Dick Radatz | Ahabs | 134 |
| Ray Herbert | Ahabs | 127 |
| Ray Culp | Black Cats | 126 |
| Ken Johnson | Mets | 123 |
| Bob Friend | Black Cats | 122 |
| Larry Jackson | Black Cats | 118 |
| Mudcat Grant | Colt 45's | 117 |
| Don Nottebart | Grays | 117 |
| Claude Osteen* | Bombers | 116 |
| Diego Segui | Ahabs | 116 |
| Jim Bouton | Saints | 112 |
| Hank Aguirre* | Bears | 111 |
| Juan Pizarro* | Colt 45's | 111 |
| Don Cardwell | Mets | 109 |
| Warren Spahn* | Frigates | 102 |
| Bob Turley | Bullies | 102 |
| Jim Kaat* | Lightning | 100 |
| Mickey Lolich* | Argonauts | 100 |
| Robin Roberts | Bears | 99 |
| John Tsitouris | Grays | 99 |
| Bob Buhl | Tigers | 98 |
| Ed Rakow | Grays | 97 |
| Curt Simmons* | Black Cats | 97 |
| Cal McLish | Bullies | 95 |
| Bob Miller | Ahabs | 95 |
| Tracy Stallard | Grays | 95 |
| Billy O'Dell* | Rockets | 94 |
| Jim O'Toole* | Saints | 94 |
| Ralph Terry | Bombers | 94 |
| Hoyt Wilhelm | Lightning | 93 |
| Stan Williams | Bullies | 93 |
| Ernie Broglio | Saints | 92 |
| Carl Willey | Jakes | 91 |
| Bob Shaw | Bombers | 90 |
| Ray Sadecki* | Bears | 89 |
| Art Mahaffey | Tigers | 87 |
| Don Lee | | 85 |
| Don Schwall | Jakes | 84 |
| Milt Pappas | Saints | 83 |
| Dave Wickersham | Rockets | 83 |
| Jack Kralick* | | 83 |
| Bob Bruce | Colt 45's | 81 |
| Bobby Bolin | Saints | 80 |
| Jim Perry | Argonauts | 79 |
| Earl Wilson | Lightning | 78 |
| John Boozer | Saints | 77 |
| Joe Gibbon* | Grays | 77 |
| Tony Cloninger | | 76 |
| Lee Stange | Lightning | 76 |
| Lew Burdette | Mets | 75 |
| Gary Bell | Ahabs | 74 |
| Tom Cheney | Tarheels | 74 |
| Roger Craig | Colt 45's | 74 |
| Ryne Duren | Colt 45's | 74 |
| Johnny Klippstein | Black Cats | 74 |
| Orlando Pena | Mets | 74 |
| Johnny Podres* | Mets | 73 |
| Bob Sadowski | Tigers | 73 |
| Stu Miller | Tigers | 71 |
| Dennis Bennett* | Lightning | 70 |
| Joey Jay | Grays | 70 |
| Barry Latman | Rockets | 69 |
| Bob Hendley* | Saints | 68 |
| Jack Lamabe | Saints | 68 |
| Bobby Shantz* | Bears | 68 |
| Steve Hamilton* | Bullies | 68 |
| Tom Sturdivant | Argonauts | 68 |
| Dick Donovan | Jakes | 67 |
| Mike McCormick* | Bombers | 66 |
| John Buzhardt | Jakes | 65 |
| Phil Regan | | 64 |
| Bo Belinsky* | Jakes | 63 |
| Moe Drabowsky | Colt 45's | 63 |
| Eddie Fisher | Mets | 62 |
| Bill Faul | Jakes | 61 |
| Galen Cisco | Grays | 60 |
| Bennie Daniels | Rockets | 60 |
| Joe Horlen | Jakes | 60 |
| Ron Taylor | Rockets | 60 |
| Al McBean | Tarheels | 58 |
| Dan Osinski | Tigers | 58 |
| Don McMahon | Bears | 56 |
| Ron Perranoski* | Frigates | 55 |
| Wes Stock | Jakes | 55 |
| Bob Veale* | Lightning | 55 |
| Hal Brown | | 54 |
| Tommie Sisk | Bombers | 54 |
| Ray Washburn | Frigates | 54 |
| Arnold Earley* | Ahabs | 53 |
| Jim Duckworth | Jakes | 51 |
| Bob Heffner | Bears | 51 |
| Hal Woodeshick* | Lightning | 51 |
| Bill Dailey | Saints | 50 |
| Glen Hobbie | Grays | 50 |
| Dave McNally* | Bears | 50 |
| Bob Allen* | Jakes | 49 |
| Earl Francis | Ahabs | 49 |
| Jim Duffalo | Tarheels | 48 |
| Bill Stafford | Jakes | 48 |
| Dallas Green | Argonauts | 47 |
| Sam McDowell* | Bears | 45 |
| Julio Navarro | Bombers | 45 |
| Gaylord Perry | Grays | 45 |
| Pete Richert* | Saints | 44 |
| Dick Drott | Rockets | 43 |
| Jay Hook | Colt 45's | 42 |
| Steve Ridzik | Argonauts | 42 |
| Jim Coates | Bullies | 42 |
| Dick Hall | Ahabs | 41 |
| Jerry Walker | Bullies | 41 |
| John Wyatt | Tarheels | 40 |
| Art Fowler | | 39 |
| Ron Piche | Frigates | 39 |
| Bob Purkey | Frigates | 39 |
| Don Rudolph* | Rockets | 39 |
| Dom Zanni | Bears | 39 |
| Hank Fischer | Black Cats | 38 |
| Frank Lary | Grays | 38 |
| Don Mossi* | Tigers | 37 |
| Jim Roland* | Ahabs | 37 |
| Jack Baldschun | Tigers | 36 |
| Ted Bowsfield* | Frigates | 35 |
| Don Elston | Frigates | 35 |
| Jack Fisher | Argonauts | 35 |
| Cal Koonce | Grays | 35 |
| Don Larsen | Bullies | 35 |
| Terry Fox | Rockets | 34 |
| Harvey Haddix* | | 34 |
| Larry Sherry | Tigers | 34 |
| Dave Stenhouse | Ahabs | 34 |
| Marshall Bridges* | Black Cats | 33 |
| Billy Pierce* | Frigates | 33 |
| Jim Owens | | 32 |
| Bill Henry* | Tigers | 31 |
| Ike Delock | Argonauts | 31 |
| Jim Bronstad | Bullies | 30 |
| Vern Law | Bombers | 30 |
| Mel Nelson* | Bullies | 30 |
| Jim Umbricht | Lightning | 30 |
| Al Worthington | Lightning | 30 |
| Chuck Estrada | Frigates | 29 |
| Barney Schultz | Mets | 29 |
| Frank Baumann* | Argonauts | 28 |
| Dave DeBusschere | Black Cats | 28 |
| Nick Willhite* | Rockets | 28 |
| George Brunet* | Bullies | 28 |
| Pete Burnside* | Bullies | 28 |
| Lindy McDaniel | Lightning | 27 |
| Early Wynn | Black Cats | 27 |
| Jim Brosnan | | 27 |
| Ted Abernathy | Tarheels | 26 |
| Chet Nichols* | Jakes | 26 |
| Bill Pleis* | Tigers | 26 |
| Hal Reniff | Lightning | 26 |
| Grover Powell* | Grays | 25 |
| Claude Raymond | Colt 45's | 24 |
| Dwight Siebler | Bears | 24 |
| Ken MacKenzie* | Black Cats | 24 |
| Ed Bauta | Argonauts | 23 |
| Bob Anderson | | 22 |
| Jim Brewer* | Bullies | 22 |
| Roy Face | | 22 |
| Ed Roebuck | Ahabs | 22 |
| Garry Roggenburk* | Ahabs | 21 |
| Larry Bearnarth | | 19 |
| Ron Nischwitz* | Bombers | 18 |
| Fred Gladding | Bullies | 17 |
| Ray Moore | Jakes | 17 |
| Bobby Tiefenauer | Saints | 17 |
| Ron Kline | Mets | 16 |
| John Miller | Saints | 16 |
| Jack Hamilton | Argonauts | 15 |
| Fred Newman | Jakes | 15 |
| Wilbur Wood* | Lightning | 15 |
| Denny McLain | Bears | 14 |
| Paul Foytack | Bears | 14 |
| Aubrey Gatewood | Grays | 13 |
| Frank Linzy | Bombers | 13 |
| Dan Pfister | Argonauts | 13 |
| Bill Fischer | Tarheels | 12 |
| Bill Kunkel | Saints | 12 |
| Pete Smith | Argonauts | 12 |
| Herm Starrette | Bombers | 12 |
| Don Rowe* | Argonauts | 11 |
| Chris Zachary | Colt 45's | 11 |
| Jim Hannan | Bullies | 10 |
| Jack Jenkins | Argonauts | 10 |
| Willie Smith* | Grays | 10 |
| Jack Warner | Black Cats | 10 |
| Bruce Howard | Argonauts | 9 |
| Fred Lasher | Rockets | 9 |
| Carl Bouldin | Bullies | 8 |
| Dick Egan* | Tigers | 8 |
| Tommy John* | Rockets | 8 |
| Dan Schneider* | Tigers | 8 |
| Bob Baird* | Argonauts | 7 |
| Tom Butters | Tarheels | 7 |
| Gordon Seyfried | Argonauts | 7 |
| Mike Fornieles | Rockets | 7 |
| Russ Kemmerer | Colt 45's | 6 |
| Ken Rowe | Saints | 6 |
| Ron Moeller* | Bullies | 6 |
| Frank Funk | Mets | 5 |
| Marcelino Lopez* | Bears | 5 |
| Aurelio Monteagudo | Tarheels | 5 |
| Fritz Ackley | Black Cats | 4 |
| Gerry Arrigo* | Tigers | 4 |
| Bob Humphreys | Rockets | 4 |
| Alan Koch | Jakes | 4 |
| Tom Metcalf | Argonauts | 4 |
| Fred Norman* | Tarheels | 4 |
| Jack Smith | Ahabs | 4 |
| Jack Spring* | Colt 45's | 3 |
| Paul Toth | Tarheels | 3 |
| Dick Calmus | Lightning | 2 |
| Gene Conley | Bullies | 2 |
| Bob Duliba | Tigers | 2 |
| Art Quirk* | Colt 45's | 2 |
| Jose Santiago | Tarheels | 2 |
| Dave Thies | Bullies | 2 |
| Wally Bunker | Argonauts | 1 |
| Freddie Burdette | Saints | 1 |
| Bob Garibaldi | Argonauts | 1 |
| Billy Hoeft* | Mets | 1 |
| Buster Narum | Rockets | 1 |
| John O'Donoghue* | Saints | 1 |
| Fred Talbot | Grays | 1 |
| Dick LeMay* | Tigers | 0 |