| Name | Name | ERA |
| Turk Farrell | Colt 45's | 1.50 |
| Bob Heffner | Bears | 2.27 |
| Ken Johnson | Mets | 2.29 |
| Bob Veale* | Lightning | 2.33 |
| Jim O'Toole* | Tourists | 2.37 |
| Sam McDowell* | Bears | 2.53 |
| Wally Bunker | Lightning | 2.61 |
| Roger Craig | Colt 45's | 2.62 |
| Jim Kaat* | Lightning | 2.63 |
| Bob Friend | Black Cats | 2.69 |
| Juan Marichal | Tarheels | 2.78 |
| Jack Sanford | Tigers | 2.86 |
| Chris Short* | Rockets | 2.90 |
| Don Drysdale | Lightning | 2.91 |
| Bob Gibson | Lightning | 2.95 |
| Larry Jackson | Black Cats | 3.00 |
| Whitey Ford* | Mets | 3.01 |
| Bennie Daniels | Rockets | 3.08 |
| Sandy Koufax* | Tarheels | 3.17 |
| Jim Maloney | Tarheels | 3.19 |
| Lew Burdette | Mets | 3.26 |
| Milt Pappas | Tourists | 3.35 |
| Bob Purkey | Frigates | 3.36 |
| Dick Ellsworth* | Argonauts | 3.37 |
| Dean Chance | Bombers | 3.40 |
| Al Jackson* | Tigers | 3.41 |
| Dave McNally* | Bears | 3.44 |
| Dave Wickersham | Rockets | 3.45 |
| Joe Horlen | Colt 45's | 3.48 |
| Bob Bruce | Colt 45's | 3.52 |
| Mickey Lolich* | Argonauts | 3.56 |
| Curt Simmons* | | 3.60 |
| Jim Bunning | Frigates | 3.62 |
| Gaylord Perry | Grays | 3.64 |
| Dick Donovan | Jakes | 3.66 |
| Ernie Broglio | Tourists | 3.68 |
| Tony Cloninger | Black Cats | 3.74 |
| Bo Belinsky* | Jakes | 3.75 |
| Pedro Ramos | Frigates | 3.81 |
| Luis Tiant | Bullies | 3.82 |
| Fred Newman | | 3.85 |
| Ray Sadecki* | Bears | 3.87 |
| Robin Roberts | Bears | 3.88 |
| Camilo Pascual | Ahabs | 3.90 |
| Galen Cisco | Grays | 3.94 |
| Hank Aguirre* | Bears | 4.00 |
| Jim Bouton | Tourists | 4.19 |
| Vern Law | Bombers | 4.21 |
| Barry Latman | Rockets | 4.23 |
| Jim Grant | Colt 45's | 4.24 |
| Ron Herbel | Mets | 4.27 |
| Bobby Bolin | Tourists | 4.29 |
| Ted Bowsfield* | | 4.32 |
| Tracy Stallard | Grays | 4.33 |
| Earl Wilson | Ahabs | 4.44 |
| Diego Segui | Ahabs | 4.47 |
| Jack Lamabe | Tourists | 4.50 |
| Sonny Siebert | Colt 45's | 4.52 |
| Rollie Sheldon | Bullies | 4.59 |
| Ray Culp | Frigates | 4.59 |
| Bob Shaw | Bombers | 4.64 |
| Al Downing* | Colt 45's | 4.67 |
| Moe Drabowsky | Jakes | 4.77 |
| John Buzhardt | Jakes | 4.79 |
| Denny Lemaster* | Rockets | 4.80 |
| Lee Stange | Tigers | 4.84 |
| Buster Narum | Rockets | 4.85 |
| Art Mahaffey | Bombers | 4.89 |
| Juan Pizarro* | Colt 45's | 4.92 |
| Orlando Pena | Mets | 5.00 |
| Don Nottebart | Grays | 5.01 |
| Joe Nuxhall* | Bullies | 5.05 |
| John Tsitouris | Grays | 5.10 |
| Jack Kralick* | Argonauts | 5.10 |
| Joe Moeller | Tigers | 5.14 |
| Bob Buhl | Tigers | 5.19 |
| Bob Sadowski | Tigers | 5.23 |
| Joey Jay | Grays | 5.24 |
| Bill Monbouquette | Frigates | 5.39 |
| Gary Peters* | Tarheels | 5.55 |
| Hank Fischer | Black Cats | 5.74 |
| Dennis Bennett* | Argonauts | 5.75 |
| Dave Morehead | Bullies | 5.91 |
| Ed Connolly* | Bullies | 5.99 |
| Alan Koch | Jakes | 5.99 |
| Jim Hannan | Bullies | 6.19 |
| Claude Osteen* | Bombers | 6.50 |
| Jack Fisher | Argonauts | 6.67 |
| Dick Stigman* | Bombers | 7.52 |
| Warren Spahn* | | 8.04 |