| Name | Name | ERA |
| Turk Farrell | Colt 45's | 1.55 |
| Bob Veale* | Lightning | 2.39 |
| Don Drysdale | Lightning | 2.41 |
| Bob Heffner | Bears | 2.46 |
| Joe Horlen | Colt 45's | 2.55 |
| Wally Bunker | Lightning | 2.63 |
| Chris Short* | Rockets | 2.63 |
| Juan Marichal | Tarheels | 2.68 |
| Bob Friend | Black Cats | 2.69 |
| Roger Craig | Colt 45's | 2.71 |
| Dick Radatz | Ahabs | 2.76 |
| Sam McDowell* | Bears | 2.77 |
| Bob Lee | Ahabs | 2.78 |
| Larry Jackson | Black Cats | 2.82 |
| Jim Kaat* | Lightning | 2.84 |
| Bob Gibson | Lightning | 2.90 |
| Ken Johnson | Mets | 2.90 |
| Jim O'Toole* | Tourists | 3.01 |
| Dean Chance | Bombers | 3.07 |
| Ray Sadecki* | Bears | 3.21 |
| Luis Tiant | Bullies | 3.22 |
| Jack Sanford | Tigers | 3.26 |
| Mickey Lolich* | Argonauts | 3.28 |
| Lew Burdette | Mets | 3.28 |
| Sandy Koufax* | Tarheels | 3.29 |
| Curt Simmons* |   | 3.31 |
| Bennie Daniels | Rockets | 3.32 |
| Joe Gibbon* | Grays | 3.41 |
| Bob Bruce | Colt 45's | 3.42 |
| Dave Wickersham | Rockets | 3.43 |
| Mel Stottlemyre | Jakes | 3.46 |
| Whitey Ford* | Mets | 3.49 |
| Jim Bunning | Frigates | 3.49 |
| Dick Ellsworth* | Argonauts | 3.52 |
| Ernie Broglio | Tourists | 3.55 |
| Dick Donovan | Jakes | 3.58 |
| Gaylord Perry | Grays | 3.61 |
| Fred Newman |   | 3.66 |
| Tony Cloninger | Black Cats | 3.69 |
| Bob Purkey | Frigates | 3.70 |
| Sonny Siebert | Colt 45's | 3.71 |
| Jim Maloney | Tarheels | 3.78 |
| Camilo Pascual | Ahabs | 3.83 |
| Tracy Stallard | Grays | 3.83 |
| Ray Herbert | Ahabs | 3.87 |
| Galen Cisco | Grays | 4.02 |
| Pedro Ramos | Frigates | 4.07 |
| Al Jackson* | Tigers | 4.08 |
| Milt Pappas | Tourists | 4.08 |
| Hank Aguirre* | Bears | 4.10 |
| Dave McNally* | Bears | 4.15 |
| Earl Wilson | Ahabs | 4.21 |
| Juan Pizarro* | Colt 45's | 4.25 |
| Bob Shaw | Bombers | 4.26 |
| Lee Stange | Tigers | 4.29 |
| Ron Herbel | Mets | 4.32 |
| Bob Buhl | Tigers | 4.37 |
| Robin Roberts | Bears | 4.38 |
| Stan Williams | Bullies | 4.40 |
| Vern Law | Bombers | 4.41 |
| Bobby Bolin | Tourists | 4.44 |
| Diego Segui | Ahabs | 4.50 |
| Jim Bouton | Tourists | 4.51 |
| Jim Grant | Colt 45's | 4.56 |
| Al Downing* | Colt 45's | 4.57 |
| Denny McLain | Bears | 4.58 |
| John Buzhardt | Jakes | 4.62 |
| Bob Hendley* | Tourists | 4.65 |
| Hal Brown | Argonauts | 4.67 |
| Orlando Pena | Mets | 4.71 |
| Bob Sadowski | Tigers | 4.76 |
| Moe Drabowsky | Jakes | 4.82 |
| Barry Latman | Rockets | 4.84 |
| Rollie Sheldon | Bullies | 4.86 |
| Art Mahaffey | Bombers | 4.86 |
| Steve Barber* | Tourists | 4.87 |
| Joe Moeller | Tigers | 4.87 |
| Jack Kralick* | Argonauts | 4.90 |
| Ted Bowsfield* |   | 4.98 |
| John Tsitouris | Grays | 5.06 |
| Phil Regan | Black Cats | 5.07 |
| Don Nottebart | Grays | 5.09 |
| Buster Narum | Rockets | 5.19 |
| Ray Culp | Frigates | 5.31 |
| Bo Belinsky* | Jakes | 5.31 |
| Bill Monbouquette | Frigates | 5.33 |
| Alan Koch | Jakes | 5.35 |
| Joey Jay | Grays | 5.35 |
| Dave Morehead | Bullies | 5.38 |
| Jack Lamabe | Tourists | 5.45 |
| Dennis Bennett* | Argonauts | 5.50 |
| Gary Peters* | Tarheels | 5.54 |
| John O'Donoghue* | Tourists | 5.60 |
| Claude Osteen* | Bombers | 5.67 |
| Jack Fisher | Argonauts | 5.78 |
| Jim Hannan | Bullies | 5.85 |
| Denny Lemaster* | Rockets | 5.89 |
| Hank Fischer | Black Cats | 5.95 |
| Joe Nuxhall* | Bullies | 6.13 |
| Phil Ortega | Mets | 6.32 |
| Dick Stigman* | Bombers | 6.80 |
| Ed Connolly* | Bullies | 7.29 |
| Warren Spahn* |   | 7.61 |
| Frank Kreutzer* | Bombers | 8.28 |