| Name | Name | ERA |
| Bob Veale* | Lightning | 2.23 |
| Jim Bunning | Tarheels | 2.42 |
| Sandy Koufax* | Tarheels | 2.42 |
| Joe Sparma | Tourists | 2.44 |
| Denny McLain | Bears | 2.45 |
| Sonny Siebert | Colt .45's | 2.49 |
| Dave Morehead | Bullies | 2.56 |
| Steve Barber* | Tourists | 2.56 |
| Juan Marichal | Tarheels | 2.85 |
| George Brunet* | Bullies | 2.86 |
| Pete Richert* | Tourists | 2.87 |
| Bobby Bolin | Tourists | 2.93 |
| Tommy John* | Rockets | 2.97 |
| Dave Wickersham | Rockets | 3.20 |
| Bob Gibson | Lightning | 3.30 |
| Dave McNally* | Bears | 3.31 |
| Bob Sadowski | Tigers | 3.32 |
| Milt Pappas | Tourists | 3.32 |
| Jim Maloney | Tarheels | 3.36 |
| Dick Ellsworth* | Argonauts | 3.43 |
| Bob Bruce | Colt .45's | 3.44 |
| Turk Farrell | Colt .45's | 3.47 |
| Robin Roberts | Bears | 3.55 |
| Jim Kaat* | Lightning | 3.59 |
| Jim Perry | Argonauts | 3.61 |
| Joe Horlen | Colt .45's | 3.61 |
| Whitey Ford* | Mets | 3.61 |
| Bob Friend | Black Cats | 3.62 |
| Don Cardwell | Mets | 3.64 |
| Tracy Stallard | Grays | 3.69 |
| Earl Wilson | Ahabs | 3.70 |
| Hank Aguirre* | Bears | 3.72 |
| Mel Stottlemyre | Jakes | 3.75 |
| Jim Grant | Colt .45's | 3.76 |
| Jim Lonborg | Colt .45's | 3.80 |
| Bill Stafford | Jakes | 3.80 |
| Sam McDowell* | Bears | 3.81 |
| Mickey Lolich* | Argonauts | 3.84 |
| Sammy Ellis | Ahabs | 3.89 |
| Larry Jackson | Black Cats | 3.90 |
| Ken Johnson | Mets | 3.90 |
| Jim Bouton | Tourists | 3.91 |
| Joey Jay | Grays | 3.93 |
| Gary Peters* | Tarheels | 3.94 |
| Luis Tiant | Bullies | 3.98 |
| Bo Belinsky* | Jakes | 4.02 |
| Chris Short* | Rockets | 4.07 |
| Dave Giusti | Bullies | 4.08 |
| Buster Narum | Rockets | 4.10 |
| Marcelino Lopez* | Bears | 4.14 |
| Ray Washburn | Frigates | 4.16 |
| Lee Stange | Tigers | 4.16 |
| Vern Law | Bombers | 4.18 |
| Wally Bunker | Lightning | 4.20 |
| John O'Donoghue* | Tourists | 4.20 |
| Joe Nuxhall* | Bullies | 4.20 |
| Bill Monbouquette | Frigates | 4.22 |
| Bob Shaw | Bombers | 4.22 |
| John Buzhardt | Jakes | 4.26 |
| Camilo Pascual | Ahabs | 4.27 |
| Al Downing* | Colt .45's | 4.28 |
| Dean Chance | Lightning | 4.32 |
| Fred Newman | Frigates | 4.33 |
| Jack Fisher | Argonauts | 4.36 |
| Al Jackson* | Tigers | 4.36 |
| Wade Blasingame* | Tigers | 4.42 |
| Cal Koonce | Grays | 4.45 |
| Ralph Terry | Bombers | 4.45 |
| Diego Segui | Ahabs | 4.49 |
| Billy McCool* | Tarheels | 4.53 |
| Curt Simmons* | Argonauts | 4.67 |
| Bob Purkey | Frigates | 4.78 |
| Claude Osteen* | Bombers | 4.79 |
| Don Nottebart | Grays | 4.79 |
| Rollie Sheldon | Bullies | 4.82 |
| Fred Talbot | Grays | 4.93 |
| Tony Cloninger | Black Cats | 4.99 |
| Bob Buhl | Tigers | 5.03 |
| Gaylord Perry | Grays | 5.12 |
| Hank Fischer | Black Cats | 5.12 |
| Ray Sadecki* | Black Cats | 5.14 |
| Ray Culp | Frigates | 5.19 |
| Don Drysdale | Bombers | 5.26 |
| John Tsitouris | Ahabs | 5.27 |
| Warren Spahn* | Jakes | 5.53 |
| Ray Herbert | Rockets | 5.54 |
| Jack Sanford | Tigers | 5.75 |
| Phil Ortega | Mets | 5.90 |
| Dave Boswell | Frigates | 6.24 |