| Name | Name | K |
| Sandy Koufax* | Tarheels | 290 |
| Sam McDowell* | Bears | 265 |
| Bob Veale* | Lightning | 262 |
| Jim Bunning | Tarheels | 207 |
| Bob Gibson | Lightning | 199 |
| Jim Maloney | Tarheels | 196 |
| Mickey Lolich* | Argonauts | 188 |
| Chris Short* | Rockets | 186 |
| Sammy Ellis | Ahabs | 183 |
| Earl Wilson | Ahabs | 162 |
| Juan Marichal | Tarheels | 161 |
| Denny McLain | Bears | 159 |
| Tony Cloninger | Black Cats | 156 |
| Whitey Ford* | Mets | 155 |
| Don Drysdale | Bombers | 152 |
| George Brunet* | Bullies | 151 |
| Claude Osteen* | Bombers | 149 |
| Luis Tiant | Bullies | 147 |
| Dick Ellsworth* | Argonauts | 144 |
| Dave Morehead | Bullies | 141 |
| Gaylord Perry | Grays | 138 |
| Dean Chance | Lightning | 136 |
| Tommy John* | Rockets | 135 |
| Bob Shaw | Bombers | 135 |
| Wade Blasingame* | Tigers | 134 |
| Steve Barber* | Tourists | 127 |
| Jim Kaat* | Lightning | 126 |
| Sonny Siebert | Colt .45's | 125 |
| Pete Richert* | Tourists | 124 |
| Ken Johnson | Mets | 124 |
| Hank Aguirre* | Bears | 122 |
| Joe Nuxhall* | Bullies | 119 |
| Ray Culp | Frigates | 116 |
| Al Downing* | Colt .45's | 116 |
| Larry Jackson | Black Cats | 115 |
| Mel Stottlemyre | Jakes | 111 |
| Billy McCool* | Tarheels | 110 |
| Al Jackson* | Tigers | 106 |
| Rollie Sheldon | Bullies | 106 |
| Ray Sadecki* | Black Cats | 104 |
| Milt Pappas | Tourists | 103 |
| Fred Talbot | Grays | 101 |
| Marcelino Lopez* | Bears | 100 |
| Joe Sparma | Tourists | 100 |
| Diego Segui | Ahabs | 98 |
| Jack Fisher | Argonauts | 97 |
| Dave McNally* | Bears | 97 |
| Turk Farrell | Colt .45's | 96 |
| Tracy Stallard | Grays | 94 |
| Bob Bruce | Colt .45's | 92 |
| Bob Buhl | Tigers | 92 |
| Warren Spahn* | Jakes | 91 |
| Bill Monbouquette | Frigates | 90 |
| Fred Newman | Frigates | 90 |
| Bo Belinsky* | Jakes | 89 |
| Jim Grant | Colt .45's | 89 |
| Don Cardwell | Mets | 87 |
| Joey Jay | Grays | 86 |
| Curt Simmons* | Argonauts | 86 |
| John Buzhardt | Jakes | 85 |
| Dave Wickersham | Rockets | 85 |
| Jim Perry | Argonauts | 84 |
| Bobby Bolin | Tourists | 83 |
| Camilo Pascual | Ahabs | 83 |
| Dave Giusti | Bullies | 81 |
| Bob Miller | Ahabs | 79 |
| Jim Lonborg | Colt .45's | 78 |
| Jim Merritt* | Rockets | 78 |
| Robin Roberts | Bears | 76 |
| John Tsitouris | Ahabs | 74 |
| Vern Law | Bombers | 73 |
| Dave Boswell | Frigates | 71 |
| Jim Bouton | Tourists | 71 |
| Joe Horlen | Colt .45's | 71 |
| Hank Fischer | Black Cats | 70 |
| Ted Abernathy | Tarheels | 69 |
| Bob Friend | Black Cats | 69 |
| Cal Koonce | Grays | 68 |
| Stu Miller | Bears | 68 |
| Ralph Terry | Bombers | 67 |
| Rudy May* | Mets | 66 |
| John O'Donoghue* | Tourists | 66 |
| Lee Stange | Tigers | 65 |
| Denny Lemaster* | Rockets | 64 |
| Dick Radatz | Ahabs | 64 |
| Ray Washburn | Frigates | 63 |
| Joe Gibbon* | Grays | 62 |
| Bruce Howard | Argonauts | 62 |
| Hoyt Wilhelm | Lightning | 61 |
| Bob Sadowski | Tigers | 60 |
| Claude Raymond | Colt .45's | 59 |
| Bill Stafford | Jakes | 58 |
| Wally Bunker | Lightning | 57 |
| Ron Herbel | Mets | 57 |
| Larry Dierker | Lightning | 56 |
| Juan Pizarro* | Colt .45's | 56 |
| Bob Lee | Ahabs | 55 |
| Gary Wagner | Ahabs | 55 |
| Ron Taylor | Rockets | 55 |
| Gary Bell | Ahabs | 54 |
| Gary Peters* | Tarheels | 53 |
| Tug McGraw* | Colt .45's | 52 |
| Jim Hunter | Bombers | 51 |
| Lindy McDaniel | Frigates | 50 |
| Billy O'Dell* | Rockets | 50 |
| Ron Perranoski* | Black Cats | 50 |
| Johnny Podres* | Mets | 50 |
| Dennis Bennett* | Argonauts | 49 |
| Hal Reniff | Argonauts | 49 |
| Eddie Fisher | Mets | 47 |
| John Miller | Tourists | 47 |
| Don Nottebart | Grays | 47 |
| Phil Ortega | Mets | 47 |
| Howie Reed | Mets | 46 |
| Bill Faul | Jakes | 45 |
| Jim O'Toole* | Tourists | 45 |
| Pedro Ramos | Frigates | 45 |
| Steve Ridzik | Argonauts | 45 |
| Bob Locker | Lightning | 44 |
| Pete Mikkelsen | Bombers | 44 |
| Buster Narum | Rockets | 44 |
| Dick Hall | Bears | 43 |
| Ray Herbert | Rockets | 43 |
| Johnny Klippstein | Bears | 43 |
| Al McBean | Tarheels | 43 |
| Orlando Pena | Mets | 43 |
| Steve Hamilton* | Bullies | 42 |
| Don McMahon | Lightning | 42 |
| Jack Baldschun | Tigers | 41 |
| Galen Cisco | Grays | 41 |
| Jim Owens | Black Cats | 41 |
| Wes Stock | Frigates | 41 |
| John Wyatt | Tarheels | 41 |
| Jack Sanford | Tigers | 41 |
| Jim Palmer | Tigers | 40 |
| Frank Carpin* | Frigates | 39 |
| Phil Niekro | Rockets | 39 |
| Al Worthington | Lightning | 39 |
| Barney Schultz | Mets | 38 |
| Bobby Tiefenauer | Tourists | 38 |
| Arnold Earley* | Ahabs | 37 |
| Larry Sherry | Tigers | 37 |
| Bill Henry* | Tigers | 37 |
| Dick Kelley* | Grays | 36 |
| Mike McCormick* | Bombers | 36 |
| Dan Osinski | Tigers | 36 |
| Wilbur Wood* | Black Cats | 35 |
| Don Larsen | Bullies | 35 |
| Hal Woodeshick* | Lightning | 35 |
| Jerry Stephenson | Jakes | 34 |
| Steve Hargan | | 33 |
| Don Mossi* | Tigers | 32 |
| Bill Pleis* | Tigers | 31 |
| Gerry Arrigo* | Tigers | 30 |
| Dick Stigman* | Bombers | 30 |
| Jim Dickson | Frigates | 29 |
| Fred Gladding | Bullies | 29 |
| Bob Humphreys | Mets | 29 |
| Howie Koplitz | Jakes | 29 |
| Bob Purkey | Frigates | 29 |
| Don Schwall | Jakes | 29 |
| Mike Cuellar* | Bears | 27 |
| Ted Davidson* | Mets | 27 |
| Terry Fox | Rockets | 27 |
| Phil Regan | Black Cats | 27 |
| Ron Kline | Mets | 26 |
| Nelson Briles | Lightning | 25 |
| Jack Aker | Colt .45's | 24 |
| Don Dennis | Bullies | 24 |
| Bob Hendley* | Tourists | 24 |
| Frank Lary | Grays | 24 |
| Marshall Bridges* | Jakes | 23 |
| Aubrey Gatewood | Grays | 23 |
| Gordie Richardson* | Argonauts | 22 |
| Moe Drabowsky | Jakes | 21 |
| Rob Gardner* | Tigers | 21 |
| Jack Kralick* | Argonauts | 21 |
| Jay Ritchie | Tourists | 21 |
| Floyd Weaver | Colt .45's | 21 |
| Jim Duffalo | Tarheels | 21 |
| Jack Cullen | Jakes | 20 |
| Art Mahaffey | Bullies | 20 |
| Dick Selma | Grays | 20 |
| Steve Carlton* | Bullies | 19 |
| Jim Coates | Frigates | 19 |
| Tom Kelley | Tourists | 19 |
| Lew Krausse | Rockets | 19 |
| Jim Brewer* | Bullies | 18 |
| Roy Face | Argonauts | 18 |
| Harvey Haddix* | Argonauts | 18 |
| Frank Linzy | Bombers | 18 |
| Ryne Duren | Colt .45's | 18 |
| Bob Duliba | Tigers | 16 |
| Barry Latman | Rockets | 16 |
| Dom Zanni | Bears | 16 |
| Lew Burdette | Jakes | 16 |
| Jack Lamabe | Tourists | 16 |
| Larry Jaster* | Black Cats | 14 |
| Mike Kekich* | Black Cats | 14 |
| Billy Hoeft* | Mets | 13 |
| Frank Bertaina* | Frigates | 12 |
| Masanori Murakami* | | 12 |
| Ernie Broglio | Bullies | 11 |
| Tommie Sisk | Bombers | 11 |
| Roger Craig | Bears | 10 |
| Dwight Siebler | Black Cats | 10 |
| Darrell Sutherland | Tourists | 10 |
| Rich Beck | Frigates | 9 |
| Clay Carroll | Rockets | 9 |
| Dennis Ribant | Frigates | 9 |
| Larry Bearnarth | Black Cats | 8 |
| Grant Jackson* | Colt .45's | 8 |
| Jim Hannan | | 7 |
| Bill Hands | Jakes | 6 |
| Chi-chi Olivo | Bears | 6 |
| Luke Walker* | Black Cats | 5 |
| Joe Coleman | Bullies | 4 |
| Ferguson Jenkins | Colt .45's | 4 |
| Frank Kreutzer* | Bombers | 4 |
| Carroll Sembera | Black Cats | 4 |
| Ken Holtzman* | Black Cats | 3 |
| Dick Joyce* | Bears | 3 |
| Jim McGlothlin | Grays | 3 |
| Greg Bollo | Tigers | 2 |
| Bennie Daniels | Rockets | 2 |
| Jerry Fosnow* | Bombers | 2 |
| John Hiller* | Bears | 2 |
| Paul Lindblad* | Bullies | 2 |
| Ed Roebuck | Lightning | 2 |
| Mike Hedlund | Bears | 1 |
| Barry Moore* | Jakes | 1 |
| Mel Nelson* | Lightning | 1 |
| Jim Ray | Bears | 1 |
| Stan Williams | Bullies | 1 |
| Jack Hamilton | Argonauts | 0 |