| Name | Name | ERA |
| Wade Blasingame* | Colonels | 0.00 |
| Roy Face | Argonauts | 0.00 |
| Mudcat Grant | Colt .45's | 0.00 |
| Bruce Howard | Argonauts | 0.00 |
| Catfish Hunter | Bombers | 0.00 |
| Pat Jarvis | Jakes | 0.00 |
| Sam McDowell* | Bears | 0.00 |
| Stu Miller | Bears | 0.00 |
| Dan Osinski | Tigers | 0.00 |
| Jim Perry | Argonauts | 0.00 |
| Minnie Rojas | Colonels | 0.00 |
| Sonny Siebert | Colt .45's | 0.00 |
| Don Cardwell | Mets | 1.00 |
| Al Jackson* | Tigers | 1.00 |
| Mike Cuellar* | Bears | 1.13 |
| Vern Law | Tigers | 1.17 |
| Gene Brabender | Colonels | 1.29 |
| Bucky Brandon | Mets | 1.29 |
| Jim Bunning | Tarheels | 1.29 |
| Tony Cloninger | Frigates | 1.29 |
| Jack Aker | Colt .45's | 1.35 |
| Hank Fischer | Jakes | 1.59 |
| Jack Hamilton | Argonauts | 1.80 |
| Bob Humphreys | Mets | 1.80 |
| Chi-Chi Olivo | Bears | 1.80 |
| George Brunet* | Bullies | 1.93 |
| Jim Maloney | Tarheels | 2.00 |
| Jim McGlothlin | Grays | 2.00 |
| Earl Wilson | Bombers | 2.00 |
| Jerry Stephenson | Jakes | 2.08 |
| Bob Veale* | Scouts | 2.08 |
| Rick Wise | Colt .45's | 2.08 |
| Bobby Bolin | Tourists | 2.12 |
| Steve Barber* | Tourists | 2.25 |
| Denny McLain | Bears | 2.25 |
| Fred Newman | Colonels | 2.25 |
| Jim Palmer | Tigers | 2.25 |
| Al Worthington | Scouts | 2.25 |
| Joe Horlen | Colt .45's | 2.35 |
| Don Dennis | Bullies | 2.45 |
| Rollie Sheldon | Bullies | 2.45 |
| Curt Simmons* | Argonauts | 2.45 |
| Don Nottebart | Grays | 2.70 |
| Turk Farrell | Colt .45's | 2.70 |
| Sandy Koufax* | Tarheels | 2.77 |
| Bob Friend | Black Cats | 2.84 |
| Dean Chance | Frigates | 3.00 |
| Pete Richert* | Tourists | 3.00 |
| Dave Giusti | Bullies | 3.18 |
| Lee Stange | Tigers | 3.27 |
| Bob Gibson | Scouts | 3.38 |
| Jack Kralick* | Argonauts | 3.38 |
| Denny Lemaster* | Rockets | 3.38 |
| Fred Talbot | Grays | 3.52 |
| Dooley Womack | Scouts | 3.60 |
| Jim Lonborg | Colt .45's | 3.68 |
| Chris Short* | Rockets | 3.78 |
| Johnny Podres* | Mets | 3.86 |
| Dave McNally* | Bears | 3.86 |
| Mickey Lolich* | Argonauts | 3.86 |
| Lew Krausse | Rockets | 3.86 |
| Whitey Ford* | Rockets | 3.86 |
| Gaylord Perry | Grays | 3.95 |
| Jim O'Toole* | Tourists | 4.00 |
| Bob Bruce | Colt .45's | 4.15 |
| Milt Pappas | Tourists | 4.15 |
| Orlando Pena | Mets | 4.15 |
| Gary Peters* | Tarheels | 4.15 |
| Ken Sanders | Mets | 4.15 |
| Steve Hargan | Colt .45's | 4.26 |
| Clay Carroll | Rockets | 4.50 |
| Jim Hannan | Black Cats | 4.50 |
| Eddie Fisher | Mets | 4.50 |
| Joey Jay | Grays | 4.50 |
| Fritz Peterson* | Frigates | 4.60 |
| Jim Kaat* | Scouts | 5.02 |
| Luis Tiant | Bullies | 5.06 |
| Marcelino Lopez* | Bears | 5.14 |
| Woodie Fryman* | Colonels | 5.59 |
| Jim Merritt* | Rockets | 5.63 |
| Bill Hands | Jakes | 6.35 |
| Juan Marichal | Tarheels | 6.48 |
| Frank Bertaina* | Frigates | 6.75 |
| Claude Osteen* | Bombers | 6.75 |
| Fergie Jenkins | Colt .45's | 6.75 |
| Tommy John* | Rockets | 7.04 |
| Steve Blass | Black Cats | 7.20 |
| Mike McCormick* | Bombers | 7.36 |
| John Buzhardt | Jakes | 7.50 |
| Don Sutton | Scouts | 7.50 |
| Larry Jackson | Black Cats | 7.71 |
| Jack Sanford | Tigers | 7.71 |
| Paul Lindblad* | Colonels | 7.94 |
| Dick Lines* | Tarheels | 7.94 |
| Mel Stottlemyre | Jakes | 7.94 |
| Nelson Briles | Colonels | 9.00 |
| Ron Perranoski* | Black Cats | 9.64 |
| Don Drysdale | Bombers | 9.64 |
| Dennis Ribant | Frigates | 10.13 |
| Ray Washburn | Frigates | 10.13 |
| Hoyt Wilhelm | Scouts | 10.38 |
| Bob Shaw | Colonels | 10.80 |
| Ken Johnson | Mets | 11.05 |
| Larry Jaster* | Black Cats | 11.57 |
| Darold Knowles* | Black Cats | 12.00 |
| Joe Nuxhall* | Bullies | 13.50 |
| Bob Priddy | Bullies | 14.73 |
| Wally Bunker | Colonels | 14.73 |
| Gary Bell | Bombers | 14.73 |
| Hal Reniff | Argonauts | 15.43 |
| Ken Holtzman* | Black Cats | 18.00 |
| Jack Fisher | Argonauts | 19.29 |
| Ron Herbel | Mets | 21.00 |