| Name | Name | ERA |
| Pat Jarvis | Jakes | 0.87 |
| Jim Maloney | Tarheels | 1.76 |
| Jim Kaat* | Scouts | 1.79 |
| Jack Hamilton | Argonauts | 1.83 |
| Jim Perry | Argonauts | 1.99 |
| Lindy McDaniel | Frigates | 2.06 |
| Steve Barber* | Tourists | 2.17 |
| Rob Gardner* | Tigers | 2.47 |
| Mike Cuellar* | Bears | 2.49 |
| Jim McGlothlin | Grays | 2.54 |
| Fred Gladding | Bullies | 2.56 |
| Bob Gibson | Scouts | 2.62 |
| Dean Chance | Frigates | 2.62 |
| Al Jackson* | Tigers | 2.64 |
| Juan Marichal | Tarheels | 2.78 |
| Eddie Fisher | Mets | 2.92 |
| Gaylord Perry | Grays | 2.97 |
| Fritz Peterson* | Frigates | 2.98 |
| Sam McDowell* | Bears | 3.00 |
| Jim Nash | Grays | 3.22 |
| Dave Boswell | Frigates | 3.26 |
| Sandy Koufax* | Tarheels | 3.27 |
| Gary Peters* | Tarheels | 3.28 |
| Steve Hargan | Colt .45's | 3.31 |
| Don Sutton | Scouts | 3.33 |
| Dave Wickersham | Rockets | 3.45 |
| Sonny Siebert | Colt .45's | 3.47 |
| Jim Bunning | Tarheels | 3.49 |
| Jerry Stephenson | Jakes | 3.49 |
| Lew Krausse | Rockets | 3.50 |
| Dave McNally* | Bears | 3.52 |
| Don Cardwell | Mets | 3.64 |
| Fergie Jenkins | Colt .45's | 3.66 |
| Jim Merritt* | Rockets | 3.71 |
| Woodie Fryman* | Colonels | 3.73 |
| Mudcat Grant | Colt .45's | 3.82 |
| Bob Veale* | Scouts | 3.87 |
| Phil Ortega | Mets | 3.91 |
| Milt Pappas | Tourists | 3.93 |
| Pete Richert* | Tourists | 3.94 |
| Hank Fischer | Jakes | 3.97 |
| Clay Carroll | Rockets | 3.99 |
| Claude Osteen* | Bombers | 4.03 |
| Joe Horlen | Colt .45's | 4.06 |
| Denny McLain | Bears | 4.08 |
| Larry Jackson | | 4.10 |
| Luis Tiant | Bullies | 4.11 |
| Larry Dierker | Scouts | 4.12 |
| Mel Stottlemyre | Jakes | 4.15 |
| Marcelino Lopez* | Bears | 4.19 |
| Bobby Bolin | Tourists | 4.22 |
| Jack Fisher | Argonauts | 4.23 |
| Ken Johnson | Mets | 4.23 |
| Denny Lemaster* | Rockets | 4.24 |
| Bob Shaw | Colonels | 4.27 |
| John Buzhardt | Jakes | 4.29 |
| Whitey Ford* | Rockets | 4.32 |
| Nelson Briles | Colonels | 4.37 |
| Jim O'Toole* | Tourists | 4.38 |
| Bob Friend | Black Cats | 4.46 |
| Johnny Podres* | Mets | 4.53 |
| Tony Cloninger | | 4.70 |
| Jim Hannan | Black Cats | 4.71 |
| Vern Law | Tigers | 4.73 |
| Bucky Brandon | Mets | 4.79 |
| Curt Simmons* | Argonauts | 4.79 |
| Al Downing* | Colt .45's | 4.83 |
| Dick Ellsworth* | Argonauts | 4.84 |
| Larry Jaster* | Black Cats | 4.85 |
| Ray Washburn | Frigates | 4.85 |
| Mickey Lolich* | Argonauts | 4.89 |
| Dave Giusti | Bullies | 4.93 |
| Don Drysdale | Bombers | 5.01 |
| Bruce Howard | Argonauts | 5.03 |
| Joe Nuxhall* | Bullies | 5.14 |
| Bill Hands | Jakes | 5.14 |
| Mike McCormick* | Bombers | 5.24 |
| Jim Lonborg | Colt .45's | 5.27 |
| Earl Wilson | Bombers | 5.32 |
| Wally Bunker | Colonels | 5.37 |
| Lee Stange | Tigers | 5.37 |
| Steve Blass | Black Cats | 5.43 |
| Catfish Hunter | Bombers | 5.45 |
| Tommy John* | Rockets | 5.47 |
| Sammy Ellis | Colonels | 5.53 |
| Joey Jay | Grays | 5.68 |
| Jim Palmer | Tigers | 5.75 |
| Blue Moon Odom | Colonels | 5.84 |
| Fred Talbot | Grays | 5.90 |
| Bob Buhl | Tigers | 5.95 |
| Chris Short* | Rockets | 6.11 |
| Gary Bell | Bombers | 6.21 |
| Ken Holtzman* | Black Cats | 6.25 |
| Ray Sadecki* | Black Cats | 6.47 |
| George Brunet* | Bullies | 6.97 |
| Ken Sanders | Mets | 7.86 |
| Ron Herbel | Mets | 7.98 |
| Rollie Sheldon | Bullies | 8.87 |