| Name | Name | ERA |
| Turk Farrell | Colt .45's | 1.70 |
| Jim Maloney | Tarheels | 1.72 |
| Jack Hamilton | Argonauts | 2.02 |
| Dean Chance | Frigates | 2.11 |
| Jim Kaat* | Scouts | 2.12 |
| Steve Barber* | Tourists | 2.17 |
| Lindy McDaniel | Frigates | 2.34 |
| Bob Gibson | Scouts | 2.36 |
| Jim Perry | Argonauts | 2.45 |
| Jim Nash | Grays | 2.45 |
| Al Jackson* | Tigers | 2.48 |
| Eddie Fisher | Mets | 2.52 |
| Don Sutton | Scouts | 2.60 |
| Rob Gardner* | Tigers | 2.79 |
| Gaylord Perry | Grays | 2.89 |
| Juan Marichal | Tarheels | 2.96 |
| Sandy Koufax* | Tarheels | 2.98 |
| Dave Wickersham | Rockets | 3.00 |
| Jim McGlothlin | Grays | 3.04 |
| Fritz Peterson* | Frigates | 3.04 |
| Mike Cuellar* | Bears | 3.10 |
| Sonny Siebert | Colt .45's | 3.13 |
| Steve Hargan | Colt .45's | 3.15 |
| Gary Peters* | Tarheels | 3.17 |
| Jim Bunning | Tarheels | 3.17 |
| Sam McDowell* | Bears | 3.21 |
| Lew Krausse | Rockets | 3.23 |
| Dave McNally* | Bears | 3.35 |
| Dave Boswell | Frigates | 3.52 |
| Cal Koonce | Grays | 3.55 |
| Luis Tiant | Bullies | 3.57 |
| Mudcat Grant | Colt .45's | 3.58 |
| Jack Fisher | Argonauts | 3.61 |
| Joe Horlen | Colt .45's | 3.63 |
| Hank Aguirre* | Bears | 3.66 |
| Bob Shaw | Colonels | 3.67 |
| Don Cardwell | Mets | 3.72 |
| Pete Richert* | Tourists | 3.81 |
| Ken Johnson | Mets | 3.81 |
| Clay Carroll | Rockets | 3.81 |
| Phil Ortega | Mets | 3.90 |
| Jim Merritt* | Rockets | 3.99 |
| John Buzhardt | Jakes | 3.99 |
| Larry Dierker | Scouts | 4.00 |
| Woodie Fryman* | Colonels | 4.03 |
| Denny Lemaster* | Rockets | 4.06 |
| Vern Law | Tigers | 4.06 |
| Larry Jackson | | 4.18 |
| Bob Friend | Black Cats | 4.18 |
| Fergie Jenkins | Colt .45's | 4.20 |
| Al Downing* | Colt .45's | 4.27 |
| Don Drysdale | Bombers | 4.28 |
| Bob Veale* | Scouts | 4.31 |
| Marcelino Lopez* | Bears | 4.34 |
| Jim O'Toole* | Tourists | 4.38 |
| Milt Pappas | Tourists | 4.39 |
| Dick Ellsworth* | Argonauts | 4.45 |
| Hank Fischer | Jakes | 4.48 |
| Bobby Bolin | Tourists | 4.53 |
| Tommy John* | Rockets | 4.57 |
| Bill Hands | Jakes | 4.60 |
| Mel Stottlemyre | Jakes | 4.60 |
| Jerry Stephenson | Jakes | 4.62 |
| Denny McLain | Bears | 4.63 |
| Mickey Lolich* | Argonauts | 4.68 |
| Tony Cloninger | | 4.72 |
| Claude Osteen* | Bombers | 4.84 |
| Ray Washburn | Frigates | 4.85 |
| Nelson Briles | Colonels | 4.86 |
| Johnny Podres* | Mets | 4.94 |
| Bob Buhl | Tigers | 4.95 |
| Lee Stange | Tigers | 4.99 |
| Catfish Hunter | Bombers | 5.00 |
| Bucky Brandon | Mets | 5.06 |
| Dave Giusti | Bullies | 5.17 |
| Bruce Howard | Argonauts | 5.20 |
| Larry Jaster* | Black Cats | 5.21 |
| Dennis Ribant | Frigates | 5.32 |
| Jim Hannan | Black Cats | 5.36 |
| Jim Lonborg | Colt .45's | 5.40 |
| Fred Talbot | Grays | 5.58 |
| Jim Palmer | Tigers | 5.58 |
| Mike McCormick* | Bombers | 5.72 |
| Sammy Ellis | Colonels | 5.75 |
| Joe Nuxhall* | Bullies | 5.76 |
| Earl Wilson | Bombers | 5.79 |
| Blue Moon Odom | Colonels | 5.84 |
| Wally Bunker | Colonels | 5.87 |
| Chris Short* | Rockets | 5.95 |
| Steve Blass | Black Cats | 5.97 |
| George Brunet* | Bullies | 6.11 |
| Ken Holtzman* | Black Cats | 6.13 |
| Joey Jay | Grays | 6.17 |
| Paul Lindblad* | Colonels | 6.41 |
| Ray Sadecki* | Black Cats | 6.85 |
| Ron Herbel | Mets | 6.91 |
| Rollie Sheldon | Bullies | 7.79 |
| Ken Sanders | Mets | 8.12 |