| Name | Name | ERA |
| Al Jackson* | Tigers | 0.67 |
| Jim Perry | Argonauts | 0.69 |
| Jim Maloney | Tarheels | 0.72 |
| Jack Hamilton | Argonauts | 1.06 |
| Pat Jarvis | Jakes | 1.08 |
| Mudcat Grant | Colt .45's | 1.29 |
| Jim Bunning | Tarheels | 1.44 |
| Jerry Stephenson | Jakes | 1.80 |
| Mike Cuellar* | Bears | 1.99 |
| Lew Krausse | Rockets | 2.25 |
| Lindy McDaniel | Frigates | 2.35 |
| Don Drysdale | Bombers | 2.56 |
| Jim McGlothlin | Grays | 2.63 |
| Rick Wise | Colt .45's | 2.70 |
| Earl Wilson | Bombers | 2.76 |
| Jim Kaat* | Scouts | 2.78 |
| Dean Chance | Frigates | 2.90 |
| Gary Peters* | Tarheels | 2.94 |
| Jim O'Toole* | Tourists | 3.13 |
| Gaylord Perry | Grays | 3.18 |
| Pete Richert* | Tourists | 3.20 |
| Bruce Howard | Argonauts | 3.22 |
| Vern Law | Tigers | 3.27 |
| Don Sutton | Scouts | 3.27 |
| Dick Ellsworth* | Argonauts | 3.29 |
| Bob Friend | Black Cats | 3.31 |
| Bobby Bolin | Tourists | 3.33 |
| Lee Stange | Tigers | 3.38 |
| Mel Stottlemyre | Jakes | 3.41 |
| Bob Gibson | Scouts | 3.41 |
| Milt Pappas | Tourists | 3.41 |
| Denny Lemaster* | Rockets | 3.47 |
| Johnny Podres* | Mets | 3.52 |
| Dave McNally* | Bears | 3.52 |
| Jim Palmer | Tigers | 3.65 |
| Bob Buhl | Tigers | 3.71 |
| Bob Veale* | Scouts | 3.75 |
| Claude Osteen* | Bombers | 3.77 |
| Sandy Koufax* | Tarheels | 3.81 |
| Sonny Siebert | Colt .45's | 3.86 |
| Larry Jackson | Black Cats | 4.19 |
| Steve Hargan | Colt .45's | 4.20 |
| Bucky Brandon | Mets | 4.26 |
| Don Cardwell | Mets | 4.26 |
| Jack Sanford | Tigers | 4.40 |
| Hank Fischer | Jakes | 4.58 |
| George Brunet* | Bullies | 4.63 |
| Chris Short* | Rockets | 4.75 |
| Jim Merritt* | Rockets | 4.80 |
| Fergie Jenkins | Colt .45's | 4.86 |
| Nelson Briles | Colonels | 5.00 |
| Denny McLain | Bears | 5.04 |
| Ken Holtzman* | Black Cats | 5.06 |
| Joe Horlen | Colt .45's | 5.06 |
| Sam McDowell* | Bears | 5.09 |
| Al Downing* | Colt .45's | 5.14 |
| Jim Hannan | Black Cats | 5.28 |
| Marcelino Lopez* | Bears | 5.30 |
| Woodie Fryman* | Colonels | 5.32 |
| Juan Marichal | Tarheels | 5.34 |
| Tommy John* | Rockets | 5.40 |
| Sammy Ellis | Colonels | 5.40 |
| Steve Barber* | Tourists | 5.40 |
| Phil Ortega | Mets | 5.48 |
| Joey Jay | Grays | 5.53 |
| Ray Washburn | Frigates | 5.68 |
| Ken Johnson | Mets | 5.73 |
| Luis Tiant | Bullies | 5.79 |
| Dave Giusti | Bullies | 5.89 |
| Fritz Peterson* | Frigates | 5.96 |
| Mickey Lolich* | Argonauts | 6.33 |
| Rollie Sheldon | Bullies | 6.50 |
| Bill Hands | Jakes | 6.66 |
| Larry Jaster* | Black Cats | 7.07 |
| Mike McCormick* | Bombers | 7.23 |
| Blue Moon Odom | Colonels | 7.24 |
| Fred Talbot | Grays | 7.29 |
| Jack Fisher | Argonauts | 7.32 |
| Joe Nuxhall* | Bullies | 7.71 |
| Steve Blass | Black Cats | 8.05 |
| Ray Sadecki* | Black Cats | 8.36 |
| Curt Simmons* | Argonauts | 8.49 |
| Bob Shaw | Colonels | 8.56 |
| Ron Herbel | Mets | 9.20 |
| Wally Bunker | Colonels | 9.82 |
| John Buzhardt | Jakes | 9.98 |