STAT-ERA-SEP -- All players in database
Regular season
| Primary |
| Name | Name | ERA |
| Jake Peavy | Rambler | 2.31 |
| Scott Kazmir* | Batkats | 2.44 |
| Jon Garland | Batkats | 2.60 |
| Daisuke Matsuzaka | Peppers | 2.70 |
| Dustin McGowan | Terriers | 2.78 |
| Jeremy Guthrie | Pumas | 2.80 |
| Javier Vazquez | T-Bones | 2.85 |
| Mark Buehrle* | Warriors | 2.87 |
| A.J. Burnett | Farmers | 3.01 |
| Shaun Marcum | Batkats | 3.15 |
| Brandon Webb | Frogs | 3.17 |
| Miguel Batista | Buskers | 3.20 |
| Fausto Carmona | Jukes | 3.26 |
| Gil Meche | Sandlappers | 3.29 |
| Johan Santana* | Marshalls | 3.29 |
| Jered Weaver | Marshalls | 3.34 |
| John Smoltz | | 3.36 |
| Erik Bedard* | Sandlappers | 3.38 |
| Kelvim Escobar | | 3.38 |
| Brian Bannister | T-Bones | 3.40 |
| Justin Verlander | Oil Barons | 3.42 |
| Chris Young | Tigers | 3.44 |
| Joe Blanton | T-Bones | 3.45 |
| Jesse Litsch | Rambler | 3.45 |
| Oliver Perez* | Colt45's | 3.46 |
| Jose Contreras | Buskers | 3.47 |
| Braden Looper | Oil Barons | 3.48 |
| Jeff Francis* | Batkats | 3.48 |
| Chien-Ming Wang | Highlanders | 3.48 |
| Roger Clemens | Marshalls | 3.52 |
| Roy Halladay | Rebels | 3.59 |
| Tim Lincecum | Dynamo | 3.59 |
| Ian Snell | Farmers | 3.59 |
| Cole Hamels* | Rockets | 3.67 |
| John Lackey | Oil Barons | 3.68 |
| Aaron Harang | | 3.70 |
| James Shields | Pumas | 3.70 |
| Aaron Cook | Frogs | 3.77 |
| Ben Sheets | Dukes | 3.80 |
| Woody Williams | T-Bones | 3.81 |
| Daniel Cabrera | | 3.82 |
| Carlos Zambrano | Farmers | 3.83 |
| Dan Haren | Colt45's | 3.87 |
| Mike Mussina | Rockets | 3.88 |
| Tim Hudson | Sandlappers | 3.91 |
| Carlos Silva | | 3.92 |
| Jason Bergmann | Warriors | 3.94 |
| Josh Towers | Powerhouse | 3.96 |
| Roy Oswalt | | 4.03 |
| Joel Pineiro | Marshalls | 4.03 |
| Edgar Gonzalez | Jukes | 4.05 |
| Dontrelle Willis* | Jukes | 4.07 |
| Curt Schilling | Frogs | 4.08 |
| Barry Zito* | Sandlappers | 4.10 |
| C.C. Sabathia* | Pumas | 4.11 |
| Jake Westbrook | Pumas | 4.13 |
| Greg Maddux | Blue Crabs | 4.18 |
| Tony Armas | Survivors | 4.20 |
| Kevin Millwood | Highlanders | 4.21 |
| Chad Billingsley | Sandlappers | 4.24 |
| Brad Penny | | 4.25 |
| Jason Marquis | River Pilots | 4.29 |
| Julian Tavarez | T-Bones | 4.30 |
| Chuck James* | Oil Barons | 4.32 |
| Doug Davis* | Barking Seals | 4.33 |
| Brett Tomko | Dukes | 4.34 |
| Matt Cain | Grays | 4.34 |
| Josh Beckett | Colt45's | 4.36 |
| Dave Bush | Batkats | 4.39 |
| Edwin Jackson | Blue Crabs | 4.39 |
| Chad Gaudin | Powerhouse | 4.40 |
| Tom Gorzelanny* | Grays | 4.44 |
| Paul Byrd | Rambler | 4.46 |
| Micah Owings | Rambler | 4.49 |
| Andy Pettitte* | Heroes | 4.49 |
| Cliff Lee* | Buskers | 4.50 |
| Odalis Perez* | Barking Seals | 4.50 |
| Paul Maholm* | | 4.51 |
| Claudio Vargas | River Pilots | 4.54 |
| John Maine | Powerhouse | 4.56 |
| Felix Hernandez | Warriors | 4.61 |
| Jason Jennings | Farmers | 4.68 |
| Jeremy Bonderman | Rebels | 4.71 |
| Brandon McCarthy | Highlanders | 4.73 |
| Matt Morris | Rebels | 4.74 |
| Jeff Suppan | Dynamo | 4.74 |
| Derek Lowe | Rockets | 4.75 |
| Sergio Mitre | Dukes | 4.79 |
| Scott Baker | Marshalls | 4.80 |
| Ted Lilly* | Terriers | 4.82 |
| Matt Belisle | Rebels | 4.85 |
| Rich Hill* | | 4.88 |
| Vicente Padilla | River Pilots | 4.92 |
| Andy Sonnanstine | Tigers | 4.95 |
| John Danks* | Peppers | 4.99 |
| Jamie Moyer* | River Pilots | 5.03 |
| Tom Glavine* | Peppers | 5.04 |
| Justin Germano | Terriers | 5.09 |
| David Wells* | Blue Crabs | 5.16 |
| Kyle Lohse | | 5.17 |
| Chris Sampson | Warriors | 5.18 |
| Josh Fogg | | 5.21 |
| Kip Wells | Heroes | 5.22 |
| Bronson Arroyo | Buskers | 5.25 |
| Robinson Tejeda | Dukes | 5.28 |
| Adam Wainwright | Terriers | 5.32 |
| Jarrod Washburn* | | 5.38 |
| Steve Trachsel | Barking Seals | 5.41 |
| Joe Kennedy* | Peppers | 5.50 |
| Mike Pelfrey | Warriors | 5.61 |
| Matt Chico* | Rebels | 5.63 |
| Kameron Loe | Highlanders | 5.65 |
| Orlando Hernandez | Barking Seals | 5.83 |
| Tim Wakefield | Tigers | 5.92 |
| Ervin Santana | Terriers | 6.07 |
| Boof Bonser | Highlanders | 6.17 |
| Livan Hernandez | Farmers | 6.32 |
| Chris Capuano* | Grays | 6.32 |
| Nate Robertson* | | 6.46 |
| Scott Olsen* | Grays | 6.92 |
| Jorge De La Rosa* | Grays | 6.96 |
| Ramon Ortiz | Blue Crabs | 7.11 |
| Mike Bacsik* | Warriors | 7.21 |
| Adam Eaton | Blue Crabs | 7.53 |
| Casey Fossum* | Jukes | 7.60 |
| Jeff Weaver | Tigers | 8.37 |