| Name | Name | ERA |
| Ryan Dempster | Warriors | 2.31 |
| John Danks* | Peppers | 2.53 |
| Cliff Lee* | Buskers | 2.59 |
| Cole Hamels* | Rockets | 2.79 |
| Tim Hudson | Sandlappers | 2.94 |
| C.C. Sabathia* | Pumas | 2.96 |
| Rich Harden | Barking Seals | 2.96 |
| Roy Halladay | Rebels | 2.97 |
| Jon Lester* | Moondogs | 3.06 |
| Matt Garza | Dynamo | 3.07 |
| Brandon Webb | Frogs | 3.08 |
| Mark Buehrle* | Warriors | 3.12 |
| Darrell Rasner | Oil Barons | 3.13 |
| Hiroki Kuroda | Blue Crabs | 3.15 |
| Jered Weaver | Marshalls | 3.16 |
| Josh Beckett | Storm Giants | 3.18 |
| Ervin Santana | Terriers | 3.20 |
| Jake Peavy | Moondogs | 3.30 |
| Scott Kazmir* | Oil Barons | 3.38 |
| Scott Baker | Marshalls | 3.40 |
| John Lackey | | 3.46 |
| Tim Wakefield | | 3.46 |
| Joe Saunders* | Pumas | 3.48 |
| Johan Santana* | Marshalls | 3.54 |
| Paul Byrd | River Pilots | 3.58 |
| Tim Lincecum | Dynamo | 3.58 |
| Daisuke Matsuzaka | Peppers | 3.59 |
| Ricky Nolasco | Oil Barons | 3.63 |
| Jeremy Guthrie | Pumas | 3.65 |
| James Shields | Pumas | 3.65 |
| Mike Pelfrey | Warriors | 3.76 |
| A.J. Burnett | Farmers | 3.78 |
| Ubaldo Jimenez | Moondogs | 3.78 |
| Zack Greinke | Terriers | 3.85 |
| Kevin Slowey | Rambler | 3.91 |
| Greg Smith* | Highlanders | 3.92 |
| Justin Duchscherer | Highlanders | 3.96 |
| Chad Billingsley | Sandlappers | 3.97 |
| Oliver Perez* | Storm Giants | 3.99 |
| Dan Haren | Storm Giants | 3.99 |
| Carlos Zambrano | Farmers | 3.99 |
| Andy Sonnanstine | Tigers | 4.01 |
| Wandy Rodriguez* | Tigers | 4.02 |
| Felix Hernandez | Warriors | 4.07 |
| Gil Meche | Sandlappers | 4.10 |
| Dave Bush | Fiddlers | 4.11 |
| Justin Verlander | Oil Barons | 4.13 |
| Joe Blanton | T-Bones | 4.13 |
| Roy Oswalt | Rockets | 4.14 |
| Nick Blackburn | T-Bones | 4.14 |
| Armando Galarraga | | 4.15 |
| Jair Jurrjens | Fiddlers | 4.15 |
| David Purcey* | Peppers | 4.16 |
| Greg Maddux | Rebels | 4.17 |
| Kyle Lohse | Farmers | 4.17 |
| Sean Gallagher | Fiddlers | 4.21 |
| Andy Pettitte* | Fiddlers | 4.25 |
| Shaun Marcum | Dynamo | 4.25 |
| Jeremy Sowers* | Buskers | 4.26 |
| Paul Maholm* | Owls | 4.26 |
| Edinson Volquez | Marshalls | 4.26 |
| Randy Johnson* | Dynamo | 4.26 |
| Matt Cain | Grays | 4.27 |
| Luke Hochevar | Rockets | 4.31 |
| Jorge De La Rosa* | Grays | 4.33 |
| John Maine | Powerhouse | 4.34 |
| Jesse Litsch | Rambler | 4.36 |
| Javier Vazquez | T-Bones | 4.40 |
| Gavin Floyd | Owls | 4.43 |
| Edwin Jackson | Blue Crabs | 4.45 |
| Cha Seung Baek | Moondogs | 4.46 |
| Derek Lowe | Rockets | 4.49 |
| Kenny Rogers* | Tigers | 4.49 |
| Jon Garland | Zeppelins | 4.50 |
| Ben Sheets | Moondogs | 4.52 |
| Mike Mussina | Rebels | 4.53 |
| Scott Olsen* | Grays | 4.53 |
| Jorge Campillo | Owls | 4.57 |
| Jason Marquis | River Pilots | 4.63 |
| Randy Wolf* | T-Bones | 4.65 |
| Clayton Kershaw* | Grays | 4.67 |
| Brett Myers | Farmers | 4.68 |
| Glen Perkins* | Grays | 4.71 |
| John Lannan* | Powerhouse | 4.76 |
| Jamie Moyer* | River Pilots | 4.80 |
| Brian Bannister | T-Bones | 4.80 |
| Johnny Cueto | Owls | 4.88 |
| Micah Owings | Jukes | 4.90 |
| Todd Wellemeyer | Frogs | 4.96 |
| Mike Hampton* | Frogs | 5.02 |
| Glendon Rusch* | Rebels | 5.08 |
| Aaron Harang | Dynamo | 5.08 |
| Ted Lilly* | Terriers | 5.09 |
| Dana Eveland* | Rambler | 5.12 |
| Jeff Francis* | Blue Crabs | 5.13 |
| Jarrod Washburn* | Fiddlers | 5.16 |
| Zach Duke* | Highlanders | 5.27 |
| Jose Contreras | Buskers | 5.27 |
| Doug Davis* | Barking Seals | 5.36 |
| Kevin Millwood | Highlanders | 5.41 |
| Aaron Cook | Frogs | 5.43 |
| Braden Looper | Zeppelins | 5.46 |
| Joel Pineiro | Barking Seals | 5.61 |
| Odalis Perez* | Barking Seals | 5.62 |
| Tim Redding | Zeppelins | 5.63 |
| Fausto Carmona | Jukes | 5.66 |
| Mark Hendrickson* | River Pilots | 5.69 |
| Shawn Chacon | | 5.71 |
| Charlie Morton | Powerhouse | 5.76 |
| Brian Moehler | Peppers | 5.79 |
| Bronson Arroyo | Buskers | 5.80 |
| Brandon Backe | Powerhouse | 5.96 |
| Daniel Cabrera | Rambler | 5.97 |
| Kyle Kendrick | Blue Crabs | 6.05 |
| Jeff Suppan | Zeppelins | 6.14 |
| Kason Gabbard* | Powerhouse | 6.37 |
| Vicente Padilla | River Pilots | 6.64 |
| Barry Zito* | Sandlappers | 6.69 |
| Tom Glavine* | Storm Giants | 6.79 |
| Jason Bergmann | Barking Seals | 7.18 |
| Carlos Silva | Barking Seals | 8.35 |