STAT-ERA-SEP -- All players in database
Regular season
| Primary |
| Name | Name | ERA |
| Josh Beckett | Storm Giants | 2.19 |
| Zack Greinke | Terriers | 2.43 |
| Aaron Cook | Frogs | 2.44 |
| Jered Weaver | Marshalls | 2.65 |
| Chris Carpenter | Sandlappers | 2.77 |
| Jason Marquis | Damage | 2.78 |
| Randy Wolf* | Rebels | 2.79 |
| Roy Halladay | Rebels | 2.82 |
| John Danks* | Peppers | 2.87 |
| Gavin Floyd | Owls | 2.89 |
| Brian Tallet* | Zeppelins | 2.93 |
| Brad Bergesen | Frogs | 2.94 |
| Brett Anderson* | Oil Barons | 2.99 |
| Clayton Kershaw* | Grays | 2.99 |
| Felix Hernandez | Warriors | 3.03 |
| Tim Lincecum | Dynamo | 3.04 |
| Josh Johnson | Grays | 3.13 |
| Ubaldo Jimenez | Moondogs | 3.14 |
| C.C. Sabathia* | Titans | 3.16 |
| James Shields | Titans | 3.17 |
| Johan Santana* | Marshalls | 3.24 |
| Jon Lester* | Moondogs | 3.24 |
| Justin Verlander | Oil Barons | 3.28 |
| A.J. Burnett | Farmers | 3.39 |
| Adam Wainwright | Terriers | 3.43 |
| Kyle Davies | Tigers | 3.46 |
| Ted Lilly* | Terriers | 3.48 |
| Cliff Lee* | Buskers | 3.53 |
| Brian Bannister | T-Bones | 3.54 |
| Matt Garza | Dynamo | 3.54 |
| Randy Wells | Warriors | 3.60 |
| Carl Pavano | Blue Crabs | 3.63 |
| Edwin Jackson | Blue Crabs | 3.64 |
| Dan Haren | Storm Giants | 3.66 |
| Mark Buehrle* | Warriors | 3.68 |
| Bronson Arroyo | Buskers | 3.68 |
| Yovani Gallardo | Jukes | 3.70 |
| Brad Penny | Blue Crabs | 3.71 |
| Rick Porcello | Tigers | 3.74 |
| Ryan Dempster | Warriors | 3.83 |
| Dallas Braden* | Hillbillies | 3.87 |
| Ross Detwiler* | Moondogs | 3.88 |
| Nick Blackburn | T-Bones | 3.88 |
| Javier Vazquez | T-Bones | 3.90 |
| Francisco Liriano* | Marshalls | 3.91 |
| Jair Jurrjens | Fiddlers | 3.93 |
| David Price* | Dynamo | 3.94 |
| Johnny Cueto | Owls | 3.95 |
| Scott Richmond | Highlanders | 3.96 |
| Tommy Hanson | Fiddlers | 3.96 |
| Jonathan Sanchez* | Terriers | 4.04 |
| Andy Pettitte* | Fiddlers | 4.05 |
| Scott Baker | Marshalls | 4.05 |
| Scott Feldman | Warriors | 4.07 |
| Joel Pineiro | Barking Seals | 4.07 |
| Jason Berken | Zeppelins | 4.07 |
| Barry Zito* | Sandlappers | 4.08 |
| Livan Hernandez | Frogs | 4.08 |
| Jose Contreras | Buskers | 4.09 |
| Jarrod Washburn* | Fiddlers | 4.14 |
| Jeremy Guthrie | Titans | 4.14 |
| Vicente Padilla | Damage | 4.16 |
| Chad Billingsley | Sandlappers | 4.20 |
| Ricky Romero* | Storm Giants | 4.21 |
| Max Scherzer | Jukes | 4.24 |
| Wandy Rodriguez* | Hillbillies | 4.24 |
| Mike Pelfrey | Owls | 4.25 |
| Shairon Martis | Jukes | 4.27 |
| Kevin Correia | Rebels | 4.40 |
| Carlos Zambrano | Rockets | 4.44 |
| Jeff Niemann | T-Bones | 4.46 |
| Brian Moehler | Peppers | 4.46 |
| John Lannan* | Hillbillies | 4.47 |
| Joe Blanton | T-Bones | 4.49 |
| Jorge de la Rosa* | Grays | 4.50 |
| Tim Wakefield | Barking Seals | 4.53 |
| Ricky Nolasco | Oil Barons | 4.54 |
| Ross Ohlendorf | Tigers | 4.56 |
| Paul Maholm* | Owls | 4.60 |
| Ervin Santana | Oil Barons | 4.60 |
| Matt Cain | Grays | 4.64 |
| Chris Volstad | Peppers | 4.68 |
| Rich Harden | Rebels | 4.68 |
| Clayton Richard* | Rambler | 4.75 |
| Roy Oswalt | Rockets | 4.77 |
| Joe Saunders* | Titans | 4.91 |
| John Lackey | Sandlappers | 5.00 |
| Ian Snell | Farmers | 5.01 |
| Kevin Millwood | Highlanders | 5.02 |
| Jason Vargas* | Frogs | 5.05 |
| Cole Hamels* | Rockets | 5.07 |
| Zach Duke* | Highlanders | 5.12 |
| Chad Gaudin | Hillbillies | 5.17 |
| Jason Hammel | Terriers | 5.28 |
| Micah Owings | Tigers | 5.36 |
| Jamie Moyer* | Damage | 5.47 |
| Luke Hochevar | Rockets | 5.49 |
| Braden Looper | Zeppelins | 5.54 |
| Derek Lowe | Farmers | 5.59 |
| Kyle Lohse | Damage | 5.64 |
| Kenshin Kawakami | Barking Seals | 5.76 |
| Doug Davis* | Barking Seals | 5.92 |
| Trevor Cahill | Farmers | 6.12 |
| Fausto Carmona | Jukes | 6.17 |
| Aaron Harang | Dynamo | 6.20 |
| Yusmeiro Petit | Owls | 6.44 |
| Jeff Suppan | Zeppelins | 7.19 |
| Mike Hampton* | Damage | 7.38 |
| Andy Sonnanstine | Tigers | 7.47 |
| Chris Tillman | Marshalls | 7.79 |