STAT-ERA-SEP -- All players in database
Regular season
| Primary |
| Name | Name | ERA |
| Tommy Hanson | Aesir | 2.05 |
| Wandy Rodriguez* | Rowdies | 2.15 |
| Josh Beckett | Storm Giants | 2.28 |
| Carlos Silva | | 2.41 |
| Adam Wainwright | Terriers | 2.41 |
| Josh Johnson | Grays | 2.47 |
| Clay Buchholz | Terriers | 2.55 |
| Ricky Romero* | Storm Giants | 2.67 |
| Clayton Kershaw* | Grays | 2.73 |
| Matt Cain | Grays | 2.74 |
| Shaun Marcum | Dynamo | 2.77 |
| Fausto Carmona | Jukes | 2.82 |
| Brian Duensing* | Aesir | 2.90 |
| Roy Halladay | Rebels | 2.91 |
| Ubaldo Jimenez | Moondogs | 2.93 |
| Jon Lester* | Moondogs | 2.99 |
| Felix Hernandez | Warriors | 3.01 |
| Trevor Cahill | Farmers | 3.03 |
| Jeff Francis* | Blue Crabs | 3.08 |
| Bronson Arroyo | Buskers | 3.09 |
| Gavin Floyd | Owls | 3.11 |
| Carlos Zambrano | Rockets | 3.12 |
| C.C. Sabathia* | Zorros | 3.12 |
| Yovani Gallardo | Jukes | 3.13 |
| Brett Myers | Farmers | 3.18 |
| Chad Billingsley | Sandlappers | 3.23 |
| Ryan Dempster | Warriors | 3.25 |
| Jeremy Bonderman | Barking Seals | 3.31 |
| Zack Greinke | Terriers | 3.34 |
| Brian Matusz* | Oil Barons | 3.36 |
| Doug Fister | Frogs | 3.38 |
| Mitch Talbot | Buskers | 3.42 |
| Anibal Sanchez | Barking Seals | 3.42 |
| Jeremy Guthrie | Zorros | 3.43 |
| Francisco Liriano* | Rhinos | 3.46 |
| Justin Verlander | Oil Barons | 3.47 |
| Jonathon Niese* | Rambler | 3.48 |
| Colby Lewis | Owls | 3.52 |
| Cliff Lee* | Buskers | 3.53 |
| Bruce Chen* | Rebels | 3.55 |
| Jhoulys Chacin | Owls | 3.56 |
| Jered Weaver | Rhinos | 3.56 |
| Joel Pineiro | Barking Seals | 3.56 |
| Bud Norris | Frogs | 3.65 |
| Jason Hammel | Terriers | 3.70 |
| Roy Oswalt | | 3.71 |
| Barry Zito* | Sandlappers | 3.74 |
| Madison Bumgarner* | Owls | 3.76 |
| R.A. Dickey | Moondogs | 3.77 |
| Aaron Cook | Aesir | 3.82 |
| Jake Arrieta | Zeppelins | 3.84 |
| Chris Narveson* | Jack Rabbits | 3.84 |
| Johan Santana* | Rhinos | 3.85 |
| Jorge de la Rosa* | Grays | 3.88 |
| Max Scherzer | Jukes | 3.88 |
| John Danks* | Jack Rabbits | 3.94 |
| Edwin Jackson | Blue Crabs | 3.95 |
| Randy Wells | Warriors | 3.97 |
| Gio Gonzalez* | Jukes | 4.01 |
| Hiroki Kuroda | Blue Crabs | 4.01 |
| Tim Wakefield | Tigers | 4.03 |
| Jake Peavy | Moondogs | 4.03 |
| John Lackey | Sandlappers | 4.13 |
| C.J. Wilson* | Storm Giants | 4.13 |
| Mat Latos | Rambler | 4.13 |
| Cole Hamels* | Rockets | 4.18 |
| Jake Westbrook | Redhawks | 4.18 |
| Hisanori Takahashi* | Frogs | 4.20 |
| Ted Lilly* | Redhawks | 4.23 |
| Tim Lincecum | Dynamo | 4.25 |
| Derek Lowe | Farmers | 4.28 |
| Armando Galarraga | Zeppelins | 4.31 |
| Livan Hernandez | Frogs | 4.33 |
| Chris Carpenter | Sandlappers | 4.34 |
| Javier Vazquez | Redhawks | 4.37 |
| Nick Blackburn | Rowdies | 4.37 |
| Carl Pavano | Blue Crabs | 4.38 |
| Matt Garza | Dynamo | 4.39 |
| Mike Pelfrey | Owls | 4.39 |
| David Price* | Dynamo | 4.44 |
| Brett Cecil* | Jack Rabbits | 4.49 |
| Daisuke Matsuzaka | Rockets | 4.50 |
| Jonathan Sanchez* | Terriers | 4.50 |
| Dan Haren | Storm Giants | 4.50 |
| Rick Porcello | Tigers | 4.51 |
| Clayton Richard* | Rambler | 4.52 |
| Tom Gorzelanny* | Redhawks | 4.54 |
| Jon Garland | Sandlappers | 4.59 |
| Tim Hudson | | 4.61 |
| Dallas Braden* | Rowdies | 4.65 |
| Ervin Santana | | 4.66 |
| Brandon Morrow | Damage | 4.68 |
| Kyle Davies | Tigers | 4.70 |
| Ian Kennedy | Jukes | 4.72 |
| A.J. Burnett | Farmers | 4.78 |
| Brad Bergesen | Frogs | 4.79 |
| Mark Buehrle* | Warriors | 4.80 |
| Paul Maholm* | Jack Rabbits | 4.80 |
| Lucas French* | Damage | 4.87 |
| Kevin Correia | Rebels | 4.91 |
| Ricky Nolasco | Oil Barons | 4.91 |
| James Shields | Zorros | 4.96 |
| Randy Wolf* | Rebels | 4.97 |
| Chris Volstad | Jack Rabbits | 5.03 |
| Freddy Garcia | Rebels | 5.07 |
| Scott Kazmir* | Zeppelins | 5.10 |
| David Huff* | Buskers | 5.17 |
| Joe Blanton | T-Bones | 5.18 |
| John Lannan* | Rowdies | 5.24 |
| Johnny Cueto | Owls | 5.33 |
| Kyle Kendrick | Blue Crabs | 5.50 |
| Jason Vargas* | Frogs | 5.52 |
| Aaron Harang | Tigers | 5.54 |
| Mike Leake | Warriors | 5.54 |
| Scott Baker | Rockets | 5.60 |
| Rodrigo Lopez | Zeppelins | 5.60 |
| Vin Mazzaro | Rambler | 5.66 |
| Jeff Niemann | T-Bones | 5.68 |
| Kyle Lohse | Damage | 5.79 |
| Phil Hughes | Dynamo | 5.81 |
| Wade LeBlanc* | Damage | 5.94 |
| Joe Saunders* | Zorros | 5.99 |
| Kevin Millwood | T-Bones | 6.17 |
| Wade Davis | Oil Barons | 6.29 |
| Dave Bush | Aesir | 6.39 |
| Ivan Nova | Moondogs | 6.77 |
| Jason Marquis | Damage | 6.81 |