* Indicates in-season trade
| Trade # | Team | Traded | To | For |
|---|---|---|---|---|
| 329 | Rambler | J.R. Towles / Micah Owings | Jukes | Dennys Reyes / 2008 2nd RDP (#14) |
| 328 | Rebels | Adrian Gonzalez / Cody Ross | Fiddlers | 2008 1st RDP (#2) |
| 327 | Dynamo | Melky Cabrera / 2008 1st RDP (#18) 2008 2nd RDP (#27) |
Tigers | 2008 1st RDP (#5) |
| 326 | River Pilots | 2008 2nd RDP (#23) / 2008 6th RDP (#8) | Rambler | Paul Byrd |
| 325 | River Pilots | Reggie Willits / Jon Rauch | Barking Seals | Jose Bautista |
| 324 | Fiddlers | Alex Rodriguez | Zeppelins | Mike Lowell / Yunel Escobar Dave Bush / Rafael Perez |
| 323 | Dynamo | Mike Hampton / Ryan Rowland-Smith Tim Redding / Jeff Suppan 2008 5th RDP (#8) |
Zeppelins | Randy Johnson / Shaun Marcum 2008 2nd RDP (#7) |
| 322 | T-Bones | Jason Kendall | Dynamo | Ben Francisco |
| 321 | Oil Barons | Justin Morneau / Braden Looper | Zepplins | Scott Kazmir / Adam LaRoche |
| 320 | River Pilots | Mark Loretta | Peppers | Juan Uribe |
| 319 | Frogs | Jose Valverde / 2008 2nd RDP(#23) | River Pilots | Akinori Iwamura |
| 318* | Colt45's | Kyle Lohse | Farmers | 2008 2nd RDP |
| 317* | Rambler | J.J. Putz | Colt45's | Daniel Cabrera |
| 316* | Colt45's | 2008 2nd RDP / 2008 3rd RDP | Oil Barons | Rich Hill |
| 315* | Highlanders | Shane Youman / Marcus McBeth | Survivors | Matt LeCroy / Mike Lieberthal Todd Walker |
| 314* | Survivors | Tyler Walker | Dynamo | Robert Fick |
| 313* | Survivors | Mike Fontenot / Justin Maxwell Travis Blackley / Jordan Tata |
Rebels | Marcus Giles / Mike Myers Nelson Cruz |
| 312* | Rockets | Jason Phillips / 2008 5th RDP | Survivors | Jamie Burke |
| 311* | Survivors | Brad Hawpe / Ken Griffey Jr. Carlos Silva / Matt Thornton Dennis Sarfate / 2008 5th RDP |
Barking Seals | Matt Kemp / Pat Maholm Yusmiero Petit / Jay Payton |
| 310* | Survivors | Jim Thome | Rockets | 2008 3rd RDP / 2008 4th RDP |
| 309* | Survivors | Brad Penny | Sandlappers | Joe Smith / 2008 2nd RDP 2008 3rd RDP |
| 308* | Dynamo | Peter Moylan | Colt45's | Edwar Ramirez / Neal Cotts |
| 307* | Survivors | Kelvim Escobar / Trevor Hoffman | Colt45's | Gavin Floyd / 2008 4th RDP |
| 306* | Survivors | Angel Pagan / Mark Lowe | Grays | Brandon Jones |
| 305* | Survivors | Jorge Posada | Colt45's | Michael Barrett / 2008 1st RDP |
| 304* | Dynamo | Jacoby Ellsbury / James Loney Jared Burton / Josh Fogg Angel pagan / Brendan Ryan |
Survivors | Aaron Harang / Milton Bradley Jack Cust / Wladimir Balentein Frank Thomas / 2008 2nd RDP |
| 303* | Dynamo | Jason Hirsh / 2008 5th RDP | Barking Seals | Matt Albers / Mike Napoli |
| 302* | Barking Seals | Pedro Martinez | Batkats | Ryan Langerhans / 2008 7th RDP |
| 301* | Barking Seals | Javier Valentin / Carlos Lee | Sandlappers | Rich Harden / Matt Kemp Matt Murton |
| 300* | Barking Seals | Aaron Hill / 2008 3rd RDP | Rambler | Anibel Sanchez |
| 299* | Frogs | Roy Oswalt | Rockets | 2008 1st RDP / Nate Robertson |
| 298* | Grays | Jose Valentin | Rambler | 2008 6th RDP |
| 297* | Heroes | John Smoltz | Rockets | Jarrod Washburn / Eulogio de la Cruz John Parrish / 2008 2nd RDP |
| 296 | Dukes | Randy Winn / Brian Tallet | Batkats | 2008 1st RDP / 2008 4th RDP Eric Bruntlett |
| 295 | Dynamo | Yusmiero Petit | Barking Seals | Matt Herges / 2008 4th RDP |
| 294 | Farmers | Gabe Gross / 2008 5th RDP | Dukes | Geoff Blum |
| 293 | River Pilots | 2008 5th RDP | Dynamo | Byung Hyun Kim |
| 292 | River Pilots | Willie Bloomquist / Bob Wickman Reggie Sanders / Rob Bowen | Tigers | Nate McLouth / 2008 4th RDP |
| 291 | River Pilots | Coco Crisp / Brendan Ryan Pedro Feliciano | Dynamo | Andre Ethier / Chris Gomez Derrick Turnbow |
| 290 | River Pilots | Mark Teahen / Casey Blake Brian Roberts | T-Bones | Reggie Willits / Dan Uggla Akinori Iwamura |
| 289 | River Pilots | Mike Fontenot | Survivors | Yorman Bazardo |
| 288 | River Pilots | Billy Petrick / 2008 4th RDP | Haymakers | Bob Wickman / Buskers 2008 5th RDP |
| 287 | River Pilots | Doug Mientkewicz / Scott Hairston | Barking Seals | Roberto Hernandez / Shawn Chacon |
| 286 | Buskers | 2008 5th RDP | Haymakers | Scott Thorman |
| 285 | Batkats | Robinson Tejeda | Haymakers | 2008 5th RDP |
| 284 | Buskers | Mark Sweeney / 2008 3rd RDP | Rebels | Dan Johnson / 2007 5th RDP |
| 283 | Pumas | Mark Teahen / Doug Mientkewicz Mark Loretta | River Pilots | Billy Butler / Delwyn Young 2008 3rd RDP |
| 282 | Rockets | 2007 5th RDP (#23) / 2007 7th RDP (#23) | Warriors | 2007 5th RDP(#18) |
| 281 | Grays | Chris Young / Paul LoDuca 2007 2nd RDP(#25) | Tigers | Scott Elarton / Mike Lieberthal 2007 1st RDP(#1) |
| 280 | Ramblers | Fred Lewis / Scott Moore 1st RDP(#22) | Jukes | J.J. Putz |
| 279 | Farmers | Greg Dobbs | Cannons | 2007 3rd RDP(#20) |
| 278 | Colt45's | 2007 4th RDP(#26) | Farmers | Edgar Gonzalez |
| 277 | Rebels | Darin Erstad / Kevin Mench | Warriors | Melvin Mora |
| 276 | Rockets | Brendan Harris / LaTroy Hawkins | Barking Seals | 2007 2nd RDP (#7) |
| 275 | Survivors | Jeff Suppan | Dynamo | 2007 4th RDP(#7) / 2007 6th RDP (#5) |
| 274 | Warriors | Jorge Posada / Aaron Harang 2007 1st RDP (#19) | Survivors | Miguel Cabrera / Chris Coste Paul Bako / Matt Thornton Juan Rivera / Justin Huber 2007 8th RDP (#26) |
| 273 | River Pilots | Pat Burrell / Michael Young | Warriors | Eric Byrnes / Orlando Cabrera |
| 272 | T-Bones | Livan Hernandez | Farmers | 2007 3rd RDP (#4) |
| 271 | Colt45's | 2007 3rd RDP (#9) | Terriers | Michael Barrett |
| 270 | Sandlappers | Byun Hyung Kim / 2007 1st RDP (#9) | Dynamo | Gil Meche |
| 269 | River Pilots | Andrew Sisco / Seth McClung | Barking Seals | Willie Bloomquist |
| 268 | River Pilots | Tony Clark / 2007 4th RDP (#3) | Terriers | Chad Durbin / Mike Fontenot |
| 267 | Pumas | Joel Piniero | Marshalls | Brian Schneider |
| 266 | Grays | Craig Counsell | T-Bones | 2007 4th RDP(#10) |
| 265 | Tigers | Josh Fogg / Tim Redding Peter Moylan / 2007 2nd RDP(#5) | Dynamo | Jeff Weaver / Kyle Davies Alfredo Amezega / Jimmy Gobble Pete Walker |
| 264 | Dynamo | Dan Haren / 2007 3rd RDP (#9) | Colt 45's | Kyle Davies / 2007 1st RDP(#6) 2007 2nd RDP(#11) |
| 263 | Marshalls | Adam LaRoche | Batkats | John Buck / Edison Volquez |
| 262 | Rockets | Gary Mathews Jr. / Juan Cruz | Powerhouses | Nick Swisher / 2007 4th RDP(#13) |
| 261 | River Pilots | Will Ohman / Jay Payton | Barking Seals | Tony Clark / 2007 4th RDP(#3) |
| 260 | Farmers | Matt Murton | Sandlappers | 2007 3rd RDP(#4) |
| 259 | Rambler | Howie Kendrick / Ken Griffey Jr. Tim Wakefield / Jack Cust | Survivors | Jake Peavy / Michael Bourn Brandon Lyon / Jamey Carroll 2007 3rd RDP(#7) |
| 258 | Rambler | Ian Kinsler / Josh Willingham 2007 4th RDP(#9) | Jukes | Matt Holliday / Damian Easley |
| 257 | Rambler | Casey Blake / Will Ohman | River Pilots | Dave Roberts / 2007 1st RDP(#13) |
| 256 | Grays | C.J. Wilson | Colt 45's | 2007 2nd RDP (#15) |
| 255 | Barking Seals | Sean Casey / Alfredo Amezega | Dynamo | Jose Bautista / Odalis Perez |
| 254 | Grays | Nick Punto | Barking Seals | 2007 3rd RDP (#13) |
| 253 | Colt45's | Jose Guillen | Batkats | 2007 2nd RDP(#15) |
| 252 | River Pilots | Mike Cameron / Jason Giambi 2007 1st RDP (#28) | Pumas | Pat Burrell / 2007 2nd RDP (#21) |
| 251 | T-Bones | 2007 3rd RDP (#26) | Colt45's | Matt Wise |
| 250 | Batkats | Gerald Laird / 2007 3rd RDP (#16) | Barking Seals | Chris Snyder |
| 249 | Colt45's | Jason Hirsh / 2007 6th RDP(#5) | Dynamo | 2007 2nd RDP (#11) |
| 248 | River Pilots | Kelly Johnson | Terriers | Shane Victorino |
| 247 | Dynamo | Wily Mo Pena | Oil Barons | Yorvit Torrealba / 2007 4th RDP (#20) |
| 246 | Haymakers | Geoff Jenkins | Farmers | 2007 3rd RDP (#6) |
| 245 | River Pilots | Casey Jannsen / Zach Miner | Batkats | Conor Jackson |
| 244 | River Pilots | Ryan Theriot | Batkats | Coco Crisp |
| 243* | Sparkplugs | Mike Gonzalez / Surv. 2007 1st RDP | Haymakers | Tony Pena / 2007 3rd RDP |
| 242* | Pumas | Miguel Cairo | Highlanders | 2007 3rd RDP |
| 241* | Farmers | 2007 7th RDP | 33's | David Newhan |
| 240* | Frogs | Mike MacDougal | Pumas | Andy Phillips |
| 239* | Survivors | 2007 1st RDP / Adam Lind Albert Callaspo | Sparkplugs | Frank Thomas / Aaron Heilmann |
| 238* | Farmers | 2007 6th RDP | Frogs | Scott Dohmann |
| 237* | Haymakers | Andrew Sisco / Horacio Ramirez Casey Janssen / 2007 1st RDP | River Pilots | Chris Carpenter / Joe Borowski Tigers 2007 4th RDP |
| 236* | Rockets | Adam Eaton / Brandon Claussen 2007 1st RDP | Jukes | Derek Lowe |
| 235* | Grays | Bobby Seay / David Newhan Rajai Davis | 33's | Aaron Guiel / Tommy Murphy |
| 234* | Rockets | 2007 3rd RDP / Gavin Floyd | 33's | Chad Qualls |
| 233* | T-Bones | Jeff Kent | Rockets | 2007 2nd RDP |
| 232* | Rockets | 2007 6th RDP | Grizzlies | Sal Fasano |
| 231* | Crush | Brian Tallet | Haymakers | 2007 4th RDP |
| 230* | Crush | Trevor Hoffman / Brandon Lyon | Survivors | Ryan Shealy / 2007 2nd RDP |
| 229* | Sparkplugs | 2007 3rd RDP | Crush | Jeff DaVanon |
| 228* | River Pilots | 2007 2nd RDP | Terriers | Ryan Theriot |
| 227* | River Pilots | Kenny
Rogers / Julio Franco Buck Coats | Highlanders | Claudio Vargas / 2007 1st RDP |
| 226* | Sparkplugs | Steve Finley / Darin Erstad | Rebels | Richie Sexson |
| 225 | Flyers | Manny Ramirez / Cliff Floyd Chan Ho Park | Sparkplugs | Jacque Jones / Frank Catalanotto John Garland |
| 224 | Tigers | Jason Giambi | River Pilots | Ben Broussard / Jason Repko |
| 223 | River Pilots | Norris Hopper / Armando Benitez | Frogs | Jason Repko |
| 222 | Cannons | Shin Shoo Choo / Choo Freeman 2007 2nd RDP | Frogs | Aaron Rowand / 2007 4th RDP |
| 221 | Dynamo | Rene Rivera | Jukes | Josh Rupe |
| 220 | Marshalls | Rob Bowen | Rockets | 2007 4th RDP |
| 219 | Sparkplugs | Elmer Dessens / 2007 4th RDP | Dynamo | Hector Carrasco |
| 218 | Frogs | Bernie Castro | Terriers | Eli Marrero |
| 217 | Colt45's | Jeff Suppan | Survivors | Jason Hirsch / 2007 4th RDP |
| 216 | Terriers | Frank Thomas / Chris Gomez | Sparkplugs | 2007 1st RDP / Phil Nevin Larry Bigbie |
| 215 | Grays | Kameron Loe / Rob Mackowiak | Tigers | Jose Valentin / C.J. Wilson |
| 214 | Colt45's | 2007 2nd RDP | Zombies | Daniel Cabrera |
| 213 | Grays | Esteban Yan / 2007 1st RDP | Zombies | Scott Sheilds |
| 212 | River Pilots | Bruce Chen / Darrell Rasner Damian Jackson / Terrance Long | Tigers | 2007 4th RDP |
| 211 | Sparkplugs | Javier Valentin / 2007 2nd RDP | Zombies | Johnny Estrada |
| 210 | Highlanders | Damason Marte / Armando Benitez | River Pilots | 2007 3rd RDP |
| 209 | T-Bones | Jeff Davanon / Brendan Donnelly | Crush | Jason Lane / 2007 3rd RDP |
| 208 | Terriers | Jason Johnson | Sparkplugs | Chad Durbin |
| 207 | River Pilots | Brandon Harper / 2007 4th RDP | Crush | Julio Franco / Rudy Seanez |
| 206 | Terriers | Jason Phillips | Rockets | Ramon Santiago |
| 205 | Zombies | Dannys Baez | Crush | Scott Cassidy |
| 204 | Marshalls | Angel Guzman | Colt45's | 2007 3rd RDP |