| Name | Name | ERA |
| General Crowder | Mutuals | 2.75 |
| Mel Harder | Knights | 2.81 |
| Snipe Hansen* | Empires | 2.82 |
| Larry French* | Titans | 2.95 |
| Johnny Allen | Leopards | 3.20 |
| Lon Warneke | Whiffenpoofs | 3.24 |
| Sam Gray | Glaziers | 3.26 |
| Tommy Thomas | Seals | 3.28 |
| Si Johnson | Seals | 3.31 |
| Huck Betts | Empires | 3.33 |
| Larry Benton | Riptide | 3.33 |
| Vic Sorrell | Leopards | 3.34 |
| Oral Hildebrand | Gassers | 3.34 |
| Lefty Stewart* | Seals | 3.35 |
| Ed Holley | Red Foxes | 3.38 |
| Red Ruffing | Leopards | 3.40 |
| Red Lucas | Empires | 3.42 |
| Red Faber | Empires | 3.45 |
| Bill Hallahan* | Colonels | 3.55 |
| Bill Swift | Frogs | 3.58 |
| Bob Brown | Empires | 3.59 |
| Clint Brown | Mutuals | 3.61 |
| Firpo Marberry | Whiffenpoofs | 3.62 |
| Dizzy Dean | Knights | 3.68 |
| Syl Johnson | Red Foxes | 3.69 |
| Flint Rhem | Red Foxes | 3.70 |
| Wes Ferrell | Whiffenpoofs | 3.72 |
| Carl Hubbell* | Mutuals | 3.77 |
| Wally Hebert* | Titans | 3.82 |
| Lefty Grove* | Riptide | 3.86 |
| Steve Swetonic | Leopards | 3.87 |
| George Uhle | Blue Sox | 3.89 |
| George Blaeholder | Whiffenpoofs | 3.89 |
| George Pipgras | Riptide | 3.89 |
| Ted Lyons | Whiffenpoofs | 3.94 |
| Ownie Carroll | Red Foxes | 3.98 |
| George Earnshaw | Riptide | 4.02 |
| Tommy Bridges | Glaziers | 4.05 |
| Tex Carleton | Knights | 4.16 |
| Bob Smith | Red Foxes | 4.37 |
| Charlie Root | Titans | 4.38 |
| Ed Durham | Frogs | 4.54 |
| Herb Pennock* | Seals | 4.55 |
| Burleigh Grimes | Colonels | 4.68 |
| Milt Gaston | Titans | 4.68 |
| Whit Wyatt | Glaziers | 4.72 |
| Freddie Fitzsimmons | Colonels | 4.75 |
| Sloppy Thurston | Empires | 4.79 |
| Lloyd Brown* | Red Foxes | 4.80 |
| Ray Benge | Frogs | 4.84 |
| Roy Mahaffey | Gassers | 4.89 |
| Lefty Gomez* | Mutuals | 4.91 |
| Paul Derringer | Knights | 4.93 |
| Tony Freitas* | Colonels | 5.09 |
| Hal Schumacher | Frogs | 5.09 |
| Danny MacFayden | Leopards | 5.12 |
| Ivy Andrews | Glaziers | 5.13 |
| Dazzy Vance | Blue Sox | 5.21 |
| Earl Whitehill* | Glaziers | 5.23 |
| Glenn Spencer | Gassers | 5.25 |
| Fred Heimach* | Frogs | 5.38 |
| Carl Fischer* | Titans | 5.45 |
| Vic Frazier | Gassers | 5.46 |
| Watty Clark* | Blue Sox | 5.47 |
| Pat Malone | Riptide | 5.49 |
| Jumbo Elliott* | Gassers | 5.59 |
| Guy Bush | Red Foxes | 5.62 |
| Chief Hogsett* | Colonels | 5.63 |
| Tom Zachary* | Blue Sox | 5.65 |
| Johnny Welch | Glaziers | 5.69 |
| Heinie Meine | Blue Sox | 5.73 |
| Gordon Rhodes | Glaziers | 5.84 |
| Bob Weiland* | Titans | 5.88 |
| Ray Kolp | Blue Sox | 5.88 |
| Leon Chagnon | Frogs | 5.94 |
| Van Mungo | Knights | 6.18 |
| Hod Lisenbee | Gassers | 6.41 |
| Jim Mooney* | Colonels | 6.58 |
| Jesse Haines | Frogs | 6.62 |
| Ed Brandt* | Blue Sox | 6.70 |
| Socks Seibold | Seals | 7.38 |
| Joe Shaute* | Frogs | 7.85 |
| Ray Phelps | Gassers | 8.30 |