| Primary |
| Name | Name | ERA |
| Carl Hubbell* | Mutuals | 2.63 |
| Dizzy Dean | Knights | 2.85 |
| Euel Moore | Blue Sox | 3.07 |
| Ralph Winegarner | Red Sox | 3.07 |
| Lefty Gomez* | Mutuals | 3.12 |
| Waite Hoyt | Titans | 3.13 |
| Tex Carleton | Knights | 3.20 |
| Paul Dean | Seals | 3.26 |
| Phil Collins | Kingfish | 3.30 |
| Lon Warneke | Whiffenpoofs | 3.32 |
| Mel Harder | Knights | 3.34 |
| Paul Derringer | Knights | 3.37 |
| Van Mungo | Knights | 3.40 |
| Bobo Newsom | Glaziers | 3.42 |
| Bob Weiland* | Titans | 3.45 |
| Tommy Bridges | Glaziers | 3.46 |
| Si Johnson | Seals | 3.47 |
| Larry French* | Titans | 3.49 |
| Wes Ferrell | Whiffenpoofs | 3.55 |
| Red Lucas | Empires | 3.58 |
| Carl Fischer* | Titans | 3.60 |
| Jimmie DeShong | Seals | 3.64 |
| Schoolboy Rowe | Colonels | 3.64 |
| Monte Weaver | Kingfish | 3.74 |
| Benny Frey | Seals | 3.75 |
| Ralph Birkofer* | Colonels | 3.81 |
| Sad Sam Jones | Blue Sox | 3.84 |
| Fred Marberry | Whiffenpoofs | 3.87 |
| Freddie Fitzsimmons | Colonels | 3.89 |
| Johnny Murphy | Gassers | 3.89 |
| Snipe Hansen* | Empires | 3.94 |
| Roy Parmelee | Frogs | 4.06 |
| Bill Walker* | Empires | 4.14 |
| Bud Tinning | Seals | 4.16 |
| Charlie Root | Titans | 4.16 |
| Rube Walberg* | Empires | 4.17 |
| Al Benton | Glaziers | 4.18 |
| Lefty Stewart* | Seals | 4.20 |
| Johnny Broaca | Whiffenpoofs | 4.21 |
| Red Ruffing | Kingfish | 4.26 |
| Johnny Welch | Glaziers | 4.38 |
| Monte Pearson | Mutuals | 4.41 |
| Earl Whitehill* | Red Sox | 4.42 |
| Dutch Leonard | Titans | 4.46 |
| Bill Hallahan* | Colonels | 4.52 |
| Huck Betts | Empires | 4.53 |
| Fritz Ostermueller* | Gassers | 4.54 |
| Dick Coffman | Empires | 4.54 |
| Ted Lyons | Whiffenpoofs | 4.66 |
| Syl Johnson | Frogs | 4.67 |
| Bobby Burke* | Seals | 4.71 |
| George Blaeholder | Whiffenpoofs | 4.71 |
| Bill Swift | Frogs | 4.75 |
| George Earnshaw | Sprudels | 4.81 |
| Curt Davis | Glaziers | 4.81 |
| Lloyd Brown* | Red Sox | 4.84 |
| Ben Cantwell | Mutuals | 4.90 |
| Flint Rhem | Red Sox | 4.90 |
| Dazzy Vance | Blue Sox | 5.04 |
| Bill Lee | Titans | 5.13 |
| Tommy Thomas | Frogs | 5.14 |
| Oral Hildebrand | Gassers | 5.15 |
| Hal Schumacher | Frogs | 5.27 |
| Allyn Stout | Colonels | 5.28 |
| Sugar Cain | Kingfish | 5.29 |
| Lefty Grove* | Sprudels | 5.31 |
| Jim Weaver | Mutuals | 5.32 |
| Pat Malone | Sprudels | 5.35 |
| Gordon Rhodes | Glaziers | 5.36 |
| Bob Brown | Empires | 5.58 |
| Roy Mahaffey | Gassers | 5.64 |
| Johnny Babich | Red Sox | 5.65 |
| Johnny Marcum | Gassers | 5.75 |
| Fred Frankhouse | Blue Sox | 5.79 |
| Boom-Boom Beck | Sprudels | 6.05 |
| Tom Zachary* | Blue Sox | 6.20 |
| Guy Bush | Red Sox | 6.23 |
| Ray Benge | Sprudels | 6.43 |
| Ed Brandt* | Blue Sox | 6.97 |