| Name | Name | ERA |
| Carl Hubbell* | Mutuals | 1.41 |
| Ted Lyons | Whiffenpoofs | 2.34 |
| Lefty Gomez* | Mutuals | 2.46 |
| Larry French* | Titans | 2.48 |
| Bucky Walters | Glaziers | 2.56 |
| Luke Hamlin | Mutuals | 2.67 |
| Mace Brown | Whiffenpoofs | 2.71 |
| Steve Sundra | Mutuals | 2.81 |
| Mel Harder | Bean Brewers | 2.82 |
| Lefty Grove* | Bean Brewers | 2.88 |
| Marius Russo* | Frogs | 2.90 |
| Chubby Dean* | Bean Brewers | 2.91 |
| Paul Derringer | Dodgers | 2.93 |
| George Caster | Golden Buddhas | 2.93 |
| Joe Sullivan* | Mutuals | 3.08 |
| Bobo Newsom | Glaziers | 3.10 |
| Denny Galehouse | Sprudels | 3.12 |
| Johnny Rigney | Dodgers | 3.21 |
| Tommy Bridges | Glaziers | 3.31 |
| Tot Pressnell | Mutuals | 3.31 |
| Jim Turner | Bean Brewers | 3.32 |
| Emerson Dickman | Whiffenpoofs | 3.33 |
| Harry Gumbert | Blue Sox | 3.33 |
| Johnny Vander Meer* | Titans | 3.35 |
| Dick Errickson | Bean Brewers | 3.36 |
| Ken Chase* | Bean Brewers | 3.43 |
| Jack Knott | Colonels | 3.44 |
| Lou Fette | Colonels | 3.44 |
| Buck Ross | Golden Buddhas | 3.45 |
| Johnny Marcum | Golden Buddhas | 3.49 |
| Dizzy Trout | Bean Brewers | 3.52 |
| Schoolboy Rowe | Colonels | 3.55 |
| Fritz Ostermueller* | Gassers | 3.57 |
| Bump Hadley | Seals | 3.58 |
| Hugh Casey | Dodgers | 3.60 |
| Curt Davis | Seals | 3.61 |
| Bill Dietrich | Atlantics | 3.61 |
| Bob Bowman | Glaziers | 3.72 |
| Fred Hutchinson | Blue Sox | 3.81 |
| Red Ruffing | Atlantics | 3.89 |
| Bill Posedel | Golden Buddhas | 3.89 |
| Eddie Smith* | Gassers | 3.96 |
| Elden Auker | Sprudels | 4.00 |
| Cliff Melton* | Blue Sox | 4.08 |
| Rip Sewell | Blue Sox | 4.12 |
| Alex Carrasquel | Colonels | 4.16 |
| Syl Johnson | Golden Buddhas | 4.19 |
| Bill Swift | Frogs | 4.22 |
| Charlie Root | Sprudels | 4.24 |
| Archie McKain* | Titans | 4.27 |
| Bob Feller | Blue Sox | 4.28 |
| Kirby Higbe | Whiffenpoofs | 4.28 |
| Oral Hildebrand | Gassers | 4.31 |
| Clyde Shoun* | Titans | 4.44 |
| Whitey Moore | Atlantics | 4.47 |
| Willis Hudlin | Seals | 4.56 |
| Lee Grissom* | Gassers | 4.59 |
| Jack Wilson | Sprudels | 4.60 |
| Milt Shoffner* | Colonels | 4.61 |
| Max Butcher | Frogs | 4.63 |
| Ray Harrell | Mutuals | 4.68 |
| Danny MacFayden | Atlantics | 4.69 |
| Lon Warneke | Whiffenpoofs | 4.72 |
| Joe Haynes | Golden Buddhas | 4.72 |
| Jim Tobin | Frogs | 4.76 |
| Tom Sunkel* | Blue Sox | 4.79 |
| Dutch Leonard | Titans | 4.84 |
| Monte Pearson | Seals | 4.84 |
| Johnny Allen | Atlantics | 4.84 |
| Claude Passeau | Sprudels | 4.85 |
| Mort Cooper | Seals | 4.85 |
| Boom-Boom Beck | Sprudels | 4.97 |
| Whit Wyatt | Golden Buddhas | 4.98 |
| Bob Klinger | Colonels | 5.00 |
| Thornton Lee* | Glaziers | 5.15 |
| Bill Lohrman | Blue Sox | 5.16 |
| Atley Donald | Dodgers | 5.17 |
| Hugh Mulcahy | Frogs | 5.19 |
| Lefty Mills* | Whiffenpoofs | 5.27 |
| Vern Kennedy | Titans | 5.31 |
| Joe Bowman | Atlantics | 5.32 |
| Bill Lee | Titans | 5.37 |
| Clint Brown | Frogs | 5.45 |
| Slick Coffman | Seals | 5.70 |
| Freddy Fitzsimmons | Colonels | 5.77 |
| Al Milnar* | Titans | 5.77 |
| Manny Salvo | Whiffenpoofs | 5.78 |
| Bill Trotter | Bean Brewers | 5.88 |
| Bill Beckmann | Golden Buddhas | 5.96 |
| Hal Schumacher | Frogs | 6.17 |
| Gene Lillard | Titans | 6.18 |
| Roxie Lawson | Seals | 6.28 |
| Lynn Nelson | Seals | 6.36 |
| Tom Earley | Gassers | 6.49 |
| John Whitehead | Gassers | 6.58 |
| Pete Appleton | Glaziers | 6.80 |
| Joe Heving | Whiffenpoofs | 6.82 |
| Bob Harris | Gassers | 7.09 |
| Nels Potter | Dodgers | 7.38 |
| Jake Wade* | Gassers | 8.06 |
| Jack Kramer | Sprudels | 9.06 |
| Jim Bagby | Golden Buddhas | 9.14 |
| George Gill | Gassers | 10.32 |