| Name | Name | ERA |
| Carl Hubbell* | Mutuals | 2.06 |
| Ted Lyons | Whiffenpoofs | 2.26 |
| Bucky Walters | Glaziers | 2.41 |
| Lefty Grove* | Bean Brewers | 2.52 |
| Luke Hamlin | Mutuals | 2.59 |
| Mel Harder | Bean Brewers | 2.61 |
| Marius Russo* | Frogs | 2.71 |
| Lefty Gomez* | Mutuals | 2.84 |
| Gene Thompson | Dodgers | 2.86 |
| Steve Sundra | Mutuals | 2.86 |
| Joe Sullivan* | Mutuals | 2.93 |
| Denny Galehouse | Sprudels | 2.96 |
| Tommy Bridges | Glaziers | 3.02 |
| Schoolboy Rowe | Colonels | 3.11 |
| Lou Fette | Colonels | 3.13 |
| Tot Pressnell | Mutuals | 3.13 |
| Larry French* | Titans | 3.15 |
| Bill McGee | Atlantics | 3.16 |
| Curt Davis | Seals | 3.23 |
| Archie McKain* |   | 3.23 |
| Bob Bowman | Glaziers | 3.23 |
| Mace Brown | Whiffenpoofs | 3.39 |
| Dutch Leonard | Titans | 3.41 |
| George Caster | Golden Buddhas | 3.47 |
| Eddie Smith* | Gassers | 3.49 |
| Harry Gumbert | Blue Sox | 3.49 |
| Dizzy Trout | Bean Brewers | 3.51 |
| Fred Hutchinson | Blue Sox | 3.56 |
| Hugh Casey | Dodgers | 3.63 |
| Bob Feller | Blue Sox | 3.78 |
| Syl Johnson | Golden Buddhas | 3.80 |
| Red Ruffing | Atlantics | 3.80 |
| Lee Grissom* | Gassers | 3.81 |
| Bobo Newsom | Glaziers | 3.88 |
| Paul Derringer | Dodgers | 3.89 |
| Bump Hadley | Seals | 3.92 |
| Johnny Rigney | Dodgers | 3.93 |
| Dizzy Dean | Sprudels | 3.94 |
| Jim Tobin | Frogs | 3.96 |
| Buck Ross | Golden Buddhas | 3.99 |
| Harry Eisenstat* | Mutuals | 4.00 |
| Bill Posedel | Golden Buddhas | 4.00 |
| Ken Chase* | Bean Brewers | 4.05 |
| Oral Hildebrand | Gassers | 4.07 |
| Fritz Ostermueller* | Gassers | 4.08 |
| Cliff Melton* | Blue Sox | 4.09 |
| Johnny Marcum | Golden Buddhas | 4.10 |
| Johnny Allen | Atlantics | 4.16 |
| Emerson Dickman | Whiffenpoofs | 4.16 |
| Dick Errickson | Bean Brewers | 4.17 |
| Kirby Higbe | Whiffenpoofs | 4.18 |
| Milt Shoffner* | Colonels | 4.20 |
| Bob Klinger | Colonels | 4.23 |
| Mort Cooper | Seals | 4.29 |
| Rip Sewell | Blue Sox | 4.39 |
| Jack Knott | Colonels | 4.43 |
| Charlie Root | Sprudels | 4.45 |
| Claude Passeau | Sprudels | 4.56 |
| Ray Harrell | Mutuals | 4.57 |
| Joe Haynes | Golden Buddhas | 4.58 |
| Elden Auker | Sprudels | 4.58 |
| Lon Warneke | Whiffenpoofs | 4.61 |
| Danny MacFayden | Atlantics | 4.62 |
| Joe Bowman | Atlantics | 4.63 |
| Whitey Moore | Atlantics | 4.64 |
| Bill Lee | Titans | 4.64 |
| Bill Swift | Frogs | 4.66 |
| Jim Turner | Bean Brewers | 4.75 |
| Clyde Shoun* | Titans | 4.76 |
| Bill Beckmann | Golden Buddhas | 4.80 |
| Clint Brown | Frogs | 4.83 |
| Roxie Lawson | Seals | 4.95 |
| Al Milnar* | Titans | 4.97 |
| Bill Lohrman | Blue Sox | 5.11 |
| Freddy Fitzsimmons | Colonels | 5.14 |
| Max Butcher | Frogs | 5.14 |
| Hugh Mulcahy | Frogs | 5.14 |
| Monte Pearson | Seals | 5.18 |
| Alex Carrasquel | Colonels | 5.21 |
| Vern Kennedy | Titans | 5.22 |
| Hal Schumacher | Frogs | 5.29 |
| Atley Donald | Dodgers | 5.29 |
| Willis Hudlin | Seals | 5.34 |
| Whit Wyatt | Golden Buddhas | 5.37 |
| Thornton Lee* | Glaziers | 5.39 |
| Tom Sunkel* | Blue Sox | 5.42 |
| Boom-Boom Beck | Sprudels | 5.44 |
| Chubby Dean* | Bean Brewers | 5.45 |
| Pete Appleton | Glaziers | 5.51 |
| Johnny Vander Meer* | Titans | 5.53 |
| Lefty Mills* | Whiffenpoofs | 5.54 |
| Jack Wilson | Sprudels | 5.55 |
| Lynn Nelson | Seals | 5.56 |
| Van Mungo | Dodgers | 5.64 |
| Joe Krakauskas* | Glaziers | 5.80 |
| Al Benton | Glaziers | 5.80 |
| Manny Salvo | Whiffenpoofs | 5.94 |
| Bob Harris | Gassers | 6.01 |
| Joe Heving | Whiffenpoofs | 6.03 |
| John Whitehead | Gassers | 6.55 |
| Jack Kramer | Sprudels | 7.03 |
| Bill Trotter | Bean Brewers | 7.27 |
| George Gill | Gassers | 7.57 |
| Nels Potter | Dodgers | 7.71 |
| Jake Wade* | Gassers | 8.43 |
| Jim Bagby | Golden Buddhas | 8.43 |