| Name | Name | ERA |
| Carl Hubbell* | Mutuals | 2.26 |
| Bucky Walters | Glaziers | 2.30 |
| Ted Lyons | Whiffenpoofs | 2.35 |
| Lefty Grove* | Bean Brewers | 2.42 |
| Luke Hamlin | Mutuals | 2.45 |
| Mel Harder | Bean Brewers | 2.61 |
| Marius Russo* | Frogs | 2.62 |
| Steve Sundra | Mutuals | 2.63 |
| Tommy Bridges | Glaziers | 2.89 |
| Joe Sullivan* | Mutuals | 2.93 |
| Bill McGee | Atlantics | 3.03 |
| Lefty Gomez* | Mutuals | 3.05 |
| Gene Thompson | Dodgers | 3.07 |
| George Caster | Golden Buddhas | 3.09 |
| Denny Galehouse | Sprudels | 3.10 |
| Curt Davis | Seals | 3.14 |
| Lou Fette | Colonels | 3.15 |
| Tot Pressnell | Mutuals | 3.17 |
| Larry French* | Titans | 3.31 |
| Schoolboy Rowe | Colonels | 3.31 |
| Bob Bowman | Glaziers | 3.40 |
| Mace Brown | Whiffenpoofs | 3.41 |
| Dizzy Trout | Bean Brewers | 3.51 |
| Archie McKain* |   | 3.52 |
| Harry Gumbert | Blue Sox | 3.58 |
| Hugh Casey | Dodgers | 3.59 |
| Paul Derringer | Dodgers | 3.64 |
| Dizzy Dean | Sprudels | 3.68 |
| Red Ruffing | Atlantics | 3.68 |
| Johnny Rigney | Dodgers | 3.75 |
| Lee Grissom* | Gassers | 3.77 |
| Ken Chase* | Bean Brewers | 3.82 |
| Bob Feller | Blue Sox | 3.84 |
| Bump Hadley | Seals | 3.86 |
| Dick Errickson | Bean Brewers | 3.86 |
| Jim Tobin | Frogs | 3.88 |
| Eddie Smith* | Gassers | 3.91 |
| Buck Ross | Golden Buddhas | 3.91 |
| Syl Johnson | Golden Buddhas | 3.93 |
| Oral Hildebrand | Gassers | 3.94 |
| Dutch Leonard | Titans | 3.97 |
| Bobo Newsom | Glaziers | 3.97 |
| Emerson Dickman | Whiffenpoofs | 4.05 |
| Mort Cooper | Seals | 4.06 |
| Bill Posedel | Golden Buddhas | 4.08 |
| Fred Hutchinson | Blue Sox | 4.10 |
| Fritz Ostermueller* | Gassers | 4.13 |
| Milt Shoffner* | Colonels | 4.20 |
| Claude Passeau | Sprudels | 4.21 |
| Bill Lee | Titans | 4.24 |
| Rip Sewell | Blue Sox | 4.26 |
| Charlie Root | Sprudels | 4.31 |
| Jack Knott | Colonels | 4.31 |
| Bill Swift | Frogs | 4.33 |
| Bob Klinger | Colonels | 4.34 |
| Joe Bowman | Atlantics | 4.36 |
| Kirby Higbe | Whiffenpoofs | 4.39 |
| Johnny Allen | Atlantics | 4.40 |
| Whitey Moore | Atlantics | 4.42 |
| Elden Auker | Sprudels | 4.42 |
| Roxie Lawson | Seals | 4.54 |
| Johnny Marcum | Golden Buddhas | 4.57 |
| Cliff Melton* | Blue Sox | 4.57 |
| Joe Haynes | Golden Buddhas | 4.64 |
| Clyde Shoun* | Titans | 4.68 |
| Clint Brown | Frogs | 4.72 |
| Lon Warneke | Whiffenpoofs | 4.72 |
| Jim Turner | Bean Brewers | 4.78 |
| Bill Beckmann | Golden Buddhas | 4.81 |
| Whit Wyatt | Golden Buddhas | 4.87 |
| Alex Carrasquel | Colonels | 4.90 |
| Danny MacFayden | Atlantics | 4.92 |
| Monte Pearson | Seals | 4.92 |
| Lefty Mills* | Whiffenpoofs | 4.93 |
| Tom Sunkel* | Blue Sox | 4.94 |
| Willis Hudlin | Seals | 4.94 |
| Bill Lohrman | Blue Sox | 5.00 |
| Al Milnar* | Titans | 5.16 |
| Boom-Boom Beck | Sprudels | 5.25 |
| Hal Schumacher | Frogs | 5.25 |
| Hugh Mulcahy | Frogs | 5.30 |
| Max Butcher | Frogs | 5.31 |
| Jack Wilson | Sprudels | 5.39 |
| Thornton Lee* | Glaziers | 5.39 |
| Atley Donald | Dodgers | 5.42 |
| Chubby Dean* | Bean Brewers | 5.42 |
| Joe Krakauskas* | Glaziers | 5.42 |
| Freddy Fitzsimmons | Colonels | 5.48 |
| Vern Kennedy | Titans | 5.55 |
| Johnny Vander Meer* | Titans | 5.61 |
| Joe Heving | Whiffenpoofs | 5.63 |
| Lynn Nelson | Seals | 5.66 |
| Al Benton | Glaziers | 5.78 |
| Bob Harris | Gassers | 6.01 |
| Manny Salvo | Whiffenpoofs | 6.56 |
| John Whitehead | Gassers | 6.59 |
| Jack Kramer | Sprudels | 7.04 |
| Bill Trotter | Bean Brewers | 7.44 |
| George Gill | Gassers | 7.59 |
| Nels Potter | Dodgers | 7.71 |
| Jim Bagby | Golden Buddhas | 7.90 |