| Name | Name | ERA |
| Carl Hubbell* | Mutuals | 1.47 |
| Emerson Dickman | Whiffenpoofs | 1.54 |
| Fred Hutchinson | Blue Sox | 1.61 |
| Luke Hamlin | Mutuals | 1.93 |
| Ted Lyons | Whiffenpoofs | 2.21 |
| Lefty Gomez* | Mutuals | 2.24 |
| Johnny Vander Meer* | Titans | 2.43 |
| Thornton Lee* | Glaziers | 2.49 |
| Jack Knott | Colonels | 2.57 |
| Tommy Bridges | Glaziers | 2.58 |
| Dizzy Dean | Sprudels | 2.66 |
| Bucky Walters | Glaziers | 2.66 |
| Lefty Grove* | Bean Brewers | 2.67 |
| Chubby Dean* | Bean Brewers | 2.75 |
| Paul Derringer | Dodgers | 2.77 |
| Jim Turner | Bean Brewers | 2.83 |
| Mace Brown | Whiffenpoofs | 2.85 |
| Larry French* | Titans | 2.89 |
| Bill Swift | Frogs | 2.91 |
| Bob Bowman | Glaziers | 2.97 |
| Johnny Rigney | Dodgers | 2.98 |
| Dick Errickson | Bean Brewers | 3.08 |
| Rip Sewell | Blue Sox | 3.14 |
| Hugh Casey | Dodgers | 3.14 |
| Steve Sundra | Mutuals | 3.18 |
| George Caster | Golden Buddhas | 3.27 |
| Johnny Marcum | Golden Buddhas | 3.43 |
| Ken Chase* | Bean Brewers | 3.44 |
| Joe Haynes | Golden Buddhas | 3.44 |
| Joe Sullivan* | Mutuals | 3.47 |
| Roxie Lawson | Seals | 3.48 |
| Jack Wilson | Sprudels | 3.48 |
| Marius Russo* | Frogs | 3.51 |
| Dizzy Trout | Bean Brewers | 3.59 |
| Alex Carrasquel | Colonels | 3.65 |
| Ira Hutchinson | Mutuals | 3.70 |
| Jim Tobin | Frogs | 3.71 |
| Willis Hudlin | Seals | 3.71 |
| Monte Pearson | Seals | 3.82 |
| Kirby Higbe | Whiffenpoofs | 3.86 |
| Denny Galehouse | Sprudels | 3.86 |
| Roy Parmelee | Frogs | 3.92 |
| Whitey Moore | Atlantics | 3.93 |
| Bill Crouch | Colonels | 3.97 |
| Johnny Allen | Atlantics | 3.98 |
| Charlie Root | Sprudels | 3.98 |
| Bill Posedel | Golden Buddhas | 4.06 |
| Curt Davis | Seals | 4.12 |
| Schoolboy Rowe | Colonels | 4.13 |
| Milt Shoffner* | Colonels | 4.14 |
| Bobo Newsom | Glaziers | 4.22 |
| Harry Gumbert | Blue Sox | 4.25 |
| Claude Passeau | Sprudels | 4.26 |
| Slick Coffman | Seals | 4.26 |
| Gene Lillard | Titans | 4.28 |
| Syl Johnson | Golden Buddhas | 4.30 |
| Dutch Leonard | Titans | 4.34 |
| Manny Salvo | Whiffenpoofs | 4.34 |
| Fritz Ostermueller* | Gassers | 4.37 |
| Mel Harder | Bean Brewers | 4.39 |
| Buck Ross | Golden Buddhas | 4.41 |
| Danny MacFayden | Atlantics | 4.42 |
| Whit Wyatt | Golden Buddhas | 4.44 |
| Earl Whitehill* | Bean Brewers | 4.44 |
| Cliff Melton* | Blue Sox | 4.45 |
| Lou Fette | Colonels | 4.50 |
| Bob Feller | Blue Sox | 4.63 |
| Tot Pressnell | Mutuals | 4.65 |
| Bill Trotter | Bean Brewers | 4.79 |
| Archie McKain* | Titans | 4.85 |
| Nels Potter | Dodgers | 4.88 |
| Red Ruffing | Atlantics | 4.95 |
| Lefty Mills* | Whiffenpoofs | 4.97 |
| Bill Lohrman | Blue Sox | 4.97 |
| Bump Hadley | Seals | 5.06 |
| Max Butcher | Frogs | 5.08 |
| Lee Grissom* | Gassers | 5.14 |
| Vern Kennedy | Titans | 5.19 |
| Joe Bowman | Atlantics | 5.24 |
| Bob Klinger | Colonels | 5.29 |
| Lynn Nelson | Seals | 5.31 |
| Oral Hildebrand | Gassers | 5.56 |
| Lon Warneke | Whiffenpoofs | 5.69 |
| Freddy Fitzsimmons | Colonels | 5.74 |
| Eddie Smith* | Gassers | 5.77 |
| Hugh Mulcahy | Frogs | 5.89 |
| Clint Brown | Frogs | 5.91 |
| Clyde Shoun* | Titans | 5.97 |
| Al Milnar* | Titans | 6.28 |
| Bill Lee | Titans | 6.33 |
| Mort Cooper | Seals | 6.39 |
| Boom-Boom Beck | Sprudels | 6.45 |
| Joe Heving | Whiffenpoofs | 6.46 |
| Elden Auker | Sprudels | 6.75 |
| Bob Harris | Gassers | 6.75 |
| Jack Kramer | Sprudels | 7.00 |
| Atley Donald | Dodgers | 7.20 |
| John Whitehead | Gassers | 7.50 |
| Bill Beckmann | Golden Buddhas | 8.06 |
| Van Mungo | Dodgers | 8.31 |
| Hal Schumacher | Frogs | 8.50 |
| Jake Wade* | Gassers | 9.77 |
| Walt Masterson | Sprudels | 9.86 |